VERZOGERTE AUSSCHEIDUNG DER AMINOGLYKOSID-ANTIBIOTIKA: BEDEUTUNG FUR DIE KLINISCHE ANWENDUNG

S. Vozeh; M. Wenk; P. Spring; F. Follath

VERZOGERTE AUSSCHEIDUNG DER AMINOGLYKOSID-ANTIBIOTIKA: BEDEUTUNG FUR DIE KLINISCHE ANWENDUNG

Translated title of the contribution: Delayed excretion of aminoglycoside antibiotics bearing on clinical use

S. Vozeh
, M. Wenk
, P. Spring
, F. Follath

University of Basel

Research output: Contribution to journal › Article › peer-review

Abstract

In 7 patients the elimination of amikacin (4), tobramycin (1) and gentamicin (2) in serum and urine was measured over several days after cessation of therapy. All three aminoglycosides showed multicompartmental pharmacokinetics with a terminal half life ranging between 46 and 150 hours. Using computer simulations, it is shown that slow drug accumulation in the body is to be expected during multiple dose therapy. Therefore, the indiscriminate use of these drugs should be avoided and the duration of therapy kept as short as possible.

Translated title of the contribution	Delayed excretion of aminoglycoside antibiotics bearing on clinical use
Original language	German
Pages (from-to)	1835-1836
Number of pages	2
Journal	Schweizerische Medizinische Wochenschrift
Volume	109
Issue number	46
Publication status	Published - 1979
Externally published	Yes

Cite this

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title = "VERZOGERTE AUSSCHEIDUNG DER AMINOGLYKOSID-ANTIBIOTIKA: BEDEUTUNG FUR DIE KLINISCHE ANWENDUNG",

abstract = "In 7 patients the elimination of amikacin (4), tobramycin (1) and gentamicin (2) in serum and urine was measured over several days after cessation of therapy. All three aminoglycosides showed multicompartmental pharmacokinetics with a terminal half life ranging between 46 and 150 hours. Using computer simulations, it is shown that slow drug accumulation in the body is to be expected during multiple dose therapy. Therefore, the indiscriminate use of these drugs should be avoided and the duration of therapy kept as short as possible.",

author = "S. Vozeh and M. Wenk and P. Spring and F. Follath",

year = "1979",

language = "German",

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T1 - VERZOGERTE AUSSCHEIDUNG DER AMINOGLYKOSID-ANTIBIOTIKA

T2 - BEDEUTUNG FUR DIE KLINISCHE ANWENDUNG

AU - Vozeh, S.

AU - Wenk, M.

AU - Spring, P.

AU - Follath, F.

PY - 1979

Y1 - 1979

N2 - In 7 patients the elimination of amikacin (4), tobramycin (1) and gentamicin (2) in serum and urine was measured over several days after cessation of therapy. All three aminoglycosides showed multicompartmental pharmacokinetics with a terminal half life ranging between 46 and 150 hours. Using computer simulations, it is shown that slow drug accumulation in the body is to be expected during multiple dose therapy. Therefore, the indiscriminate use of these drugs should be avoided and the duration of therapy kept as short as possible.

AB - In 7 patients the elimination of amikacin (4), tobramycin (1) and gentamicin (2) in serum and urine was measured over several days after cessation of therapy. All three aminoglycosides showed multicompartmental pharmacokinetics with a terminal half life ranging between 46 and 150 hours. Using computer simulations, it is shown that slow drug accumulation in the body is to be expected during multiple dose therapy. Therefore, the indiscriminate use of these drugs should be avoided and the duration of therapy kept as short as possible.

UR - https://www.scopus.com/pages/publications/0018628995

M3 - Article

C2 - 515722

AN - SCOPUS:0018628995

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JO - Schweizerische Medizinische Wochenschrift

JF - Schweizerische Medizinische Wochenschrift

IS - 46

ER -

VERZOGERTE AUSSCHEIDUNG DER AMINOGLYKOSID-ANTIBIOTIKA: BEDEUTUNG FUR DIE KLINISCHE ANWENDUNG

Abstract

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