Towards quantifying immune diversity through HLA genomics

Dinesh Velayutham; Zainab Jan; Puthen Veettil Jithesh; Hamdi Mbarek

doi:10.1038/s41576-026-00996-6

Towards quantifying immune diversity through HLA genomics

Dinesh Velayutham
, Zainab Jan
, Puthen Veettil Jithesh
, Hamdi Mbarek^*

^*Corresponding author for this work

Qatar Foundation HQ
University of Liverpool

Research output: Contribution to journal › Editorial

Abstract

Emerging computational approaches that measure the functional impact of HLA variation offer an opportunity to represent aspects of antigen-presentation diversity as quantitative genomic measures rather than as solely as categorical genetic features. The era of population genomics now provides the scale needed to benchmark these approaches and determine whether such measures can serve as proxies for immune diversity.

Original language	English
Number of pages	2
Journal	Nature Reviews Genetics
Early online date	Jul 2026
DOIs	https://doi.org/10.1038/s41576-026-00996-6
Publication status	Published - 31 Jul 2026

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title = "Towards quantifying immune diversity through HLA genomics",

abstract = "Emerging computational approaches that measure the functional impact of HLA variation offer an opportunity to represent aspects of antigen-presentation diversity as quantitative genomic measures rather than as solely as categorical genetic features. The era of population genomics now provides the scale needed to benchmark these approaches and determine whether such measures can serve as proxies for immune diversity.",

author = "Dinesh Velayutham and Zainab Jan and Jithesh, \{Puthen Veettil\} and Hamdi Mbarek",

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AU - Velayutham, Dinesh

AU - Jan, Zainab

AU - Jithesh, Puthen Veettil

AU - Mbarek, Hamdi

PY - 2026/7/31

Y1 - 2026/7/31

N2 - Emerging computational approaches that measure the functional impact of HLA variation offer an opportunity to represent aspects of antigen-presentation diversity as quantitative genomic measures rather than as solely as categorical genetic features. The era of population genomics now provides the scale needed to benchmark these approaches and determine whether such measures can serve as proxies for immune diversity.

AB - Emerging computational approaches that measure the functional impact of HLA variation offer an opportunity to represent aspects of antigen-presentation diversity as quantitative genomic measures rather than as solely as categorical genetic features. The era of population genomics now provides the scale needed to benchmark these approaches and determine whether such measures can serve as proxies for immune diversity.

UR - https://www.scopus.com/pages/publications/105046412300

U2 - 10.1038/s41576-026-00996-6

DO - 10.1038/s41576-026-00996-6

M3 - Editorial

AN - SCOPUS:105046412300

SN - 1471-0056

JO - Nature Reviews Genetics

JF - Nature Reviews Genetics

ER -

Towards quantifying immune diversity through HLA genomics

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