Therapeutic targeting of the TPX2/TTK network in colorectal cancer

Keyphrases

• Therapeutic Targeting 100%
• TPX2 100%
• Putative Drug Targets 25%
• Clinical Application 16%
• Novel Therapeutics 16%
• Cas9 Protein 16%
• Gene Targeting 16%
• Differential Expression Analysis 16%
• LRP8 16%
• DDX39A 16%
• Drug-gene Interaction 16%
• Colorectal Cancer Pathogenesis 16%
• Precision Medicine 8%
• Cell Cycle Progression 8%
• Novel Therapeutic Targets 8%
• Culture Conditions 8%
• Cell Proliferation 8%
• Recent Advances 8%
• Cell Death 8%
• Three-dimensional (3D) 8%
• Flow Cytometry 8%
• Therapeutic Potential 8%
• Functional Screen 8%
• Colorectal Cancer Cells 8%
• Ingenuity Pathway Analysis 8%
• Upregulated Genes 8%
• Structural Modeling 8%
• Treatment Regimen 8%
• Molecular Docking 8%
• Bioinformatics Analysis 8%
• Growth Potential 8%
• Colony Formation 8%
• Tumor Tissue 8%
• Fluorescent Microscopy 8%
• Cell Cycle Regulation 8%
• Three-dimensional Culture 8%
• Gene Set Enrichment Analysis 8%
• Colony Forming Units 8%
• Integral Component 8%
• Metastatic Disease 8%
• Cell Cycle Distribution 8%
• Matrigel 8%
• BIRC5 8%
• Druggable Gene 8%
• Cancer Tissue 8%
• Changes in Lifestyle 8%
• Oncogenic Role 8%
• STRING Database 8%
• Cyclin-dependent Kinase 1 (CDK1) 8%
• CLC Genomics Workbench 8%
• Colorectal Cancer Mortality 8%
• Cancer Proliferation 8%
• Alternative Treatment Strategies 8%
• Organoid Formation 8%
• Illumina Platform 8%
• Effect Database 8%
• Interaction Analysis 8%
• Drug Interaction Database 8%
• Metastatic Recurrence 8%
• Aurora Kinase A (AURKA) 8%

Pharmacology, Toxicology and Pharmaceutical Science

• Colorectal Carcinoma 100%
• Drug Interaction 28%
• Carcinogenesis 14%
• Neoplasm 7%
• Cancer Mortality 7%
• Recurrent Disease 7%
• Flow Cytometry 7%
• Colon Adenocarcinoma 7%

Biochemistry, Genetics and Molecular Biology

• Colony Forming Unit S 8%