The signaling duo CXCL12 and CXCR4: Chemokine fuel for breast cancer tumorigenesis

Karolina A. Zielińska; Vladimir L. Katanaev

doi:10.3390/cancers12103071

The signaling duo CXCL12 and CXCR4: Chemokine fuel for breast cancer tumorigenesis

Karolina A. Zielińska
, Vladimir L. Katanaev^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

67 Citations (Scopus)

Abstract

The CXCL12/CXCR4 signaling pathway has emerged in the recent years as a key player in breast cancer tumorigenesis. This pathway controls many aspects of breast cancer development including cancer cell proliferation, motility and metastasis to all target organs. Moreover, the CXCL12/CXCR4 cascade affects both immune and stromal cells, creating tumor-supporting microenvironment. In this review, we examine state-of-the-art knowledge about detrimental roles of the CXCL12/CXCR4 signaling, discuss its therapeutic potential and suggest further research directions beneficial both for basic research and personalized medicine in breast cancer.

Original language	English
Article number	3071
Pages (from-to)	1-21
Number of pages	21
Journal	Cancers
Volume	12
Issue number	10
DOIs	https://doi.org/10.3390/cancers12103071
Publication status	Published - Oct 2020
Externally published	Yes

Keywords

Breast cancer
CXCL12
CXCR4
Chemokine receptors
Chemokines
SDF1

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10.3390/cancers12103071

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@article{e2fbd904b52c40f3ae7cd2795ef7a045,

title = "The signaling duo CXCL12 and CXCR4: Chemokine fuel for breast cancer tumorigenesis",

abstract = "The CXCL12/CXCR4 signaling pathway has emerged in the recent years as a key player in breast cancer tumorigenesis. This pathway controls many aspects of breast cancer development including cancer cell proliferation, motility and metastasis to all target organs. Moreover, the CXCL12/CXCR4 cascade affects both immune and stromal cells, creating tumor-supporting microenvironment. In this review, we examine state-of-the-art knowledge about detrimental roles of the CXCL12/CXCR4 signaling, discuss its therapeutic potential and suggest further research directions beneficial both for basic research and personalized medicine in breast cancer.",

keywords = "Breast cancer, CXCL12, CXCR4, Chemokine receptors, Chemokines, SDF1",

author = "Zieli{\'n}ska, \{Karolina A.\} and Katanaev, \{Vladimir L.\}",

note = "Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2020",

month = oct,

doi = "10.3390/cancers12103071",

language = "English",

volume = "12",

pages = "1--21",

journal = "Cancers",

issn = "2072-6694",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "10",

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TY - JOUR

T1 - The signaling duo CXCL12 and CXCR4

T2 - Chemokine fuel for breast cancer tumorigenesis

AU - Zielińska, Karolina A.

AU - Katanaev, Vladimir L.

PY - 2020/10

Y1 - 2020/10

N2 - The CXCL12/CXCR4 signaling pathway has emerged in the recent years as a key player in breast cancer tumorigenesis. This pathway controls many aspects of breast cancer development including cancer cell proliferation, motility and metastasis to all target organs. Moreover, the CXCL12/CXCR4 cascade affects both immune and stromal cells, creating tumor-supporting microenvironment. In this review, we examine state-of-the-art knowledge about detrimental roles of the CXCL12/CXCR4 signaling, discuss its therapeutic potential and suggest further research directions beneficial both for basic research and personalized medicine in breast cancer.

AB - The CXCL12/CXCR4 signaling pathway has emerged in the recent years as a key player in breast cancer tumorigenesis. This pathway controls many aspects of breast cancer development including cancer cell proliferation, motility and metastasis to all target organs. Moreover, the CXCL12/CXCR4 cascade affects both immune and stromal cells, creating tumor-supporting microenvironment. In this review, we examine state-of-the-art knowledge about detrimental roles of the CXCL12/CXCR4 signaling, discuss its therapeutic potential and suggest further research directions beneficial both for basic research and personalized medicine in breast cancer.

KW - Breast cancer

KW - CXCL12

KW - CXCR4

KW - Chemokine receptors

KW - Chemokines

KW - SDF1

UR - https://www.scopus.com/pages/publications/85093915766

U2 - 10.3390/cancers12103071

DO - 10.3390/cancers12103071

M3 - Review article

AN - SCOPUS:85093915766

SN - 2072-6694

VL - 12

SP - 1

EP - 21

JO - Cancers

JF - Cancers

IS - 10

M1 - 3071

ER -

The signaling duo CXCL12 and CXCR4: Chemokine fuel for breast cancer tumorigenesis

Abstract

Keywords

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