TY - JOUR
T1 - The Netherlands twin register biobank
T2 - A resource for genetic epidemiological studies
AU - Willemsen, Gonneke
AU - De Geus, Eco J.C.
AU - Bartels, Meike
AU - Van Beijsterveldt, C. E.M.Toos
AU - Brooks, Andy I.
AU - Estourgie-van Burk, G. Frederique
AU - Fugman, Douglas A.
AU - Hoekstra, Chantal
AU - Hottenga, Jouke Jan
AU - Kluft, Kees
AU - Meijer, Piet
AU - Montgomery, Grant W.
AU - Rizzu, Patrizia
AU - Sondervan, David
AU - Smit, August B.
AU - Spijker, Sabine
AU - Suchiman, H. Eka D.
AU - Tischfield, Jay A.
AU - Lehner, Thomas
AU - Slagboom, P. Eline
AU - Boomsma, Dorret I.
PY - 2010/6
Y1 - 2010/6
N2 - In 2004 the Netherlands Twin Register (NTR) started a large scale biological sample collection in twin families to create a resource for genetic studies on health, lifestyle and personality. Between January 2004 and July 2008, adult participants from NTR research projects were invited into the study. During a home visit between 7:00 and 10:00 am, fasting blood and morning urine samples were collected. Fertile women were bled on day 2-4 of the menstrual cycle, or in their pill-free week. Biological samples were collected for DNA isolation, gene expression studies, creation of cell lines and for biomarker assessment. At the time of blood sampling, additional phenotypic information concerning health, medication use, body composition and smoking was collected. Of the participants contacted, 69% participated. Blood and urine samples were collected in 9,530 participants (63% female, average age 44.4 (SD 15.5) years) from 3,477 families. Lipid profile, glucose, insulin, HbA1c, haematology, CRP, fibrinogen, liver enzymes and creatinine have been assessed. Longitudinal survey data on health, personality and lifestyle are currently available for 90% of all participants. Genome-wide SNP data are available for 3,524 participants, with additional genotyping ongoing. The NTR biobank, combined with the extensive phenotypic information available within the NTR, provides a valuable resource for the study of genetic determinants of individual differences in mental and physical health. It offers opportunities for DNA-based and gene expression studies as well as for future metabolomic and proteomic projects.
AB - In 2004 the Netherlands Twin Register (NTR) started a large scale biological sample collection in twin families to create a resource for genetic studies on health, lifestyle and personality. Between January 2004 and July 2008, adult participants from NTR research projects were invited into the study. During a home visit between 7:00 and 10:00 am, fasting blood and morning urine samples were collected. Fertile women were bled on day 2-4 of the menstrual cycle, or in their pill-free week. Biological samples were collected for DNA isolation, gene expression studies, creation of cell lines and for biomarker assessment. At the time of blood sampling, additional phenotypic information concerning health, medication use, body composition and smoking was collected. Of the participants contacted, 69% participated. Blood and urine samples were collected in 9,530 participants (63% female, average age 44.4 (SD 15.5) years) from 3,477 families. Lipid profile, glucose, insulin, HbA1c, haematology, CRP, fibrinogen, liver enzymes and creatinine have been assessed. Longitudinal survey data on health, personality and lifestyle are currently available for 90% of all participants. Genome-wide SNP data are available for 3,524 participants, with additional genotyping ongoing. The NTR biobank, combined with the extensive phenotypic information available within the NTR, provides a valuable resource for the study of genetic determinants of individual differences in mental and physical health. It offers opportunities for DNA-based and gene expression studies as well as for future metabolomic and proteomic projects.
KW - DNA
KW - GWAS
KW - Mental health
KW - Physical health
KW - RNA
UR - https://www.scopus.com/pages/publications/77953719116
U2 - 10.1375/twin.13.3.231
DO - 10.1375/twin.13.3.231
M3 - Article
C2 - 20477721
AN - SCOPUS:77953719116
SN - 1832-4274
VL - 13
SP - 231
EP - 245
JO - Twin Research and Human Genetics
JF - Twin Research and Human Genetics
IS - 3
ER -