The Internal Ribosome Entry Site in Circular RNAs

Queenie Fernandes; Zeenath Safira K.M. Yoosuf; Sarra Mestiri; Laila Assami; Karama Makni-Maalej; Shahab Uddin; Maysaloun Merhi; Said Dermime

doi:10.1007/978-981-96-9428-0_9

^*Corresponding author for this work

HBKU College of Health & Life Sciences

Hamad Medical Corporation
Qatar University
HBKU College of Health and Life Sciences

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Citation (Scopus)

Abstract

The internal ribosome entry site (IRES) within circular RNAs (circRNAs) has emerged as a dynamic and multifaceted regulatory element, challenging traditional notions of translation initiation in eukaryotic cells. This chapter reviews the current state of research and knowledge on IRES in circRNAs, exploring its molecular mechanisms, physiological roles, and therapeutic implications. As the field continues to evolve, research efforts are essential for a comprehensive understanding of the interplay between IRES and circRNAs. This work also highlights the future directions in the study of IRES within circRNAs, underscoring its significance in gene expression regulation and opening new avenues for therapeutic innovation.

Original language	English
Title of host publication	Advances in Experimental Medicine and Biology
Publisher	Springer
Pages	131-148
Number of pages	18
DOIs	https://doi.org/10.1007/978-981-96-9428-0_9
Publication status	Published - Sept 2025

Publication series

Name	Advances in Experimental Medicine and Biology
Volume	1485
ISSN (Print)	0065-2598
ISSN (Electronic)	2214-8019

Keywords

Cap-independent translation
Circular RNA (circRNA)
Internal Ribosome Entry Site (IRES)
IRES trans-acting factors (ITAFs)
Non-canonical translation;
RNA translation mechanisms

Access to Document

10.1007/978-981-96-9428-0_9

Cite this

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title = "The Internal Ribosome Entry Site in Circular RNAs",

abstract = "The internal ribosome entry site (IRES) within circular RNAs (circRNAs) has emerged as a dynamic and multifaceted regulatory element, challenging traditional notions of translation initiation in eukaryotic cells. This chapter reviews the current state of research and knowledge on IRES in circRNAs, exploring its molecular mechanisms, physiological roles, and therapeutic implications. As the field continues to evolve, research efforts are essential for a comprehensive understanding of the interplay between IRES and circRNAs. This work also highlights the future directions in the study of IRES within circRNAs, underscoring its significance in gene expression regulation and opening new avenues for therapeutic innovation.",

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AU - Yoosuf, Zeenath Safira K.M.

AU - Mestiri, Sarra

AU - Assami, Laila

AU - Makni-Maalej, Karama

AU - Uddin, Shahab

AU - Merhi, Maysaloun

AU - Dermime, Said

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KW - Cap-independent translation

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KW - Internal Ribosome Entry Site (IRES)

KW - IRES trans-acting factors (ITAFs)

KW - Non-canonical translation;

KW - RNA translation mechanisms

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