The impact of COVID-19 on “biological aging”

Fathima Humaira Amanullah; Tanvir Alam; Nady El Hajj; Yosra Bejaoui

doi:10.3389/fimmu.2024.1399676

The impact of COVID-19 on “biological aging”

Fathima Humaira Amanullah
, Tanvir Alam
, Nady El Hajj
, Yosra Bejaoui^*

^*Corresponding author for this work

Hamad bin Khalifa University

Research output: Contribution to journal › Review article › peer-review

7 Citations (Scopus)

Abstract

The global impact of the SARS-CoV-2 pandemic has been unprecedented, posing a significant public health challenge. Chronological age has been identified as a key determinant for severe outcomes associated with SARS-CoV-2 infection. Epigenetic age acceleration has previously been observed in various diseases including human immunodeficiency virus (HIV), Cytomegalovirus (CMV), cardiovascular diseases, and cancer. However, a comprehensive review of this topic is still missing in the field. In this review, we explore and summarize the research work focusing on biological aging markers, i.e., epigenetic age and telomere attrition in COVID-19 patients. From the reviewed articles, we identified a consistent pattern of epigenetic age dysregulation and shortened telomere length, revealing the impact of COVID-19 on epigenetic aging and telomere attrition.

Original language	English
Article number	1399676
Number of pages	7
Journal	Frontiers in Immunology
Volume	15
DOIs	https://doi.org/10.3389/fimmu.2024.1399676
Publication status	Published - 10 Jun 2024

Keywords

Biological aging
Covid-19
DNA methylation
Epigenetic clocks
Telomere attrition

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10.3389/fimmu.2024.1399676

Cite this

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title = "The impact of COVID-19 on “biological aging”",

abstract = "The global impact of the SARS-CoV-2 pandemic has been unprecedented, posing a significant public health challenge. Chronological age has been identified as a key determinant for severe outcomes associated with SARS-CoV-2 infection. Epigenetic age acceleration has previously been observed in various diseases including human immunodeficiency virus (HIV), Cytomegalovirus (CMV), cardiovascular diseases, and cancer. However, a comprehensive review of this topic is still missing in the field. In this review, we explore and summarize the research work focusing on biological aging markers, i.e., epigenetic age and telomere attrition in COVID-19 patients. From the reviewed articles, we identified a consistent pattern of epigenetic age dysregulation and shortened telomere length, revealing the impact of COVID-19 on epigenetic aging and telomere attrition.",

keywords = "Biological aging, Covid-19, DNA methylation, Epigenetic clocks, Telomere attrition",

author = "\{Humaira Amanullah\}, Fathima and Tanvir Alam and \{El Hajj\}, Nady and Yosra Bejaoui",

note = "Publisher Copyright: Copyright {\textcopyright} 2024 Humaira Amanullah, Alam, El Hajj and Bejaoui.",

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doi = "10.3389/fimmu.2024.1399676",

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T1 - The impact of COVID-19 on “biological aging”

AU - Humaira Amanullah, Fathima

AU - Alam, Tanvir

AU - El Hajj, Nady

AU - Bejaoui, Yosra

PY - 2024/6/10

Y1 - 2024/6/10

N2 - The global impact of the SARS-CoV-2 pandemic has been unprecedented, posing a significant public health challenge. Chronological age has been identified as a key determinant for severe outcomes associated with SARS-CoV-2 infection. Epigenetic age acceleration has previously been observed in various diseases including human immunodeficiency virus (HIV), Cytomegalovirus (CMV), cardiovascular diseases, and cancer. However, a comprehensive review of this topic is still missing in the field. In this review, we explore and summarize the research work focusing on biological aging markers, i.e., epigenetic age and telomere attrition in COVID-19 patients. From the reviewed articles, we identified a consistent pattern of epigenetic age dysregulation and shortened telomere length, revealing the impact of COVID-19 on epigenetic aging and telomere attrition.

AB - The global impact of the SARS-CoV-2 pandemic has been unprecedented, posing a significant public health challenge. Chronological age has been identified as a key determinant for severe outcomes associated with SARS-CoV-2 infection. Epigenetic age acceleration has previously been observed in various diseases including human immunodeficiency virus (HIV), Cytomegalovirus (CMV), cardiovascular diseases, and cancer. However, a comprehensive review of this topic is still missing in the field. In this review, we explore and summarize the research work focusing on biological aging markers, i.e., epigenetic age and telomere attrition in COVID-19 patients. From the reviewed articles, we identified a consistent pattern of epigenetic age dysregulation and shortened telomere length, revealing the impact of COVID-19 on epigenetic aging and telomere attrition.

KW - Biological aging

KW - Covid-19

KW - DNA methylation

KW - Epigenetic clocks

KW - Telomere attrition

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DO - 10.3389/fimmu.2024.1399676

M3 - Review article

C2 - 38919619

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VL - 15

JO - Frontiers in Immunology

JF - Frontiers in Immunology

M1 - 1399676

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The impact of COVID-19 on “biological aging”

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Keywords

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