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The ENIGMA Consortium: Large-scale collaborative analyses of neuroimaging and genetic data

  • Paul M. Thompson
  • , Jason L. Stein
  • , Sarah E. Medland
  • , Derrek P. Hibar
  • , Alejandro Arias Vasquez
  • , Miguel E. Renteria
  • , Roberto Toro
  • , Neda Jahanshad
  • , Gunter Schumann
  • , Barbara Franke
  • , Margaret J. Wright
  • , Nicholas G. Martin
  • , Ingrid Agartz
  • , Martin Alda
  • , Saud Alhusaini
  • , Laura Almasy
  • , Jorge Almeida
  • , Kathryn Alpert
  • , Nancy C. Andreasen
  • , Ole A. Andreassen
  • Liana G. Apostolova, Katja Appel, Nicola J. Armstrong, Benjamin Aribisala, Mark E. Bastin, Michael Bauer, Carrie E. Bearden, Ørjan Bergmann, Elisabeth B. Binder, John Blangero, Henry J. Bockholt, Erlend Bøen, Catherine Bois, Dorret I. Boomsma, Tom Booth, Ian J. Bowman, Janita Bralten, Rachel M. Brouwer, Han G. Brunner, David G. Brohawn, Randy L. Buckner, Jan Buitelaar, Kazima Bulayeva, Juan R. Bustillo, Vince D. Calhoun, Dara M. Cannon, Rita M. Cantor, Melanie A. Carless, Xavier Caseras, Gianpiero L. Cavalleri, M. Mallar Chakravarty, Kiki D. Chang, Christopher R.K. Ching, Andrea Christoforou, Sven Cichon, Vincent P. Clark, Patricia Conrod, Giovanni Coppola, Benedicto Crespo-Facorro, Joanne E. Curran, Michael Czisch, Ian J. Deary, Eco J.C. de Geus, Anouk den Braber, Giuseppe Delvecchio, Chantal Depondt, Lieuwe de Haan, Greig I. de Zubicaray, Danai Dima, Rali Dimitrova, Srdjan Djurovic, Hongwei Dong, Gary Donohoe, Ravindranath Duggirala, Thomas D. Dyer, Stefan Ehrlich, Carl Johan Ekman, Torbjørn Elvsåshagen, Louise Emsell, Susanne Erk, Thomas Espeseth, Jesen Fagerness, Scott Fears, Iryna Fedko, Guillén Fernández, Simon E. Fisher, Tatiana Foroud, Peter T. Fox, Clyde Francks, Sophia Frangou, Eva Maria Frey, Thomas Frodl, Vincent Frouin, Hugh Garavan, Sudheer Giddaluru, David C. Glahn, Beata Godlewska, Rita Z. Goldstein, Randy L. Gollub, Hans J. Grabe, Oliver Grimm, Oliver Gruber, Tulio Guadalupe, Raquel E. Gur, Ruben C. Gur, Harald H.H. Göring, Saskia Hagenaars, Tomas Hajek, Geoffrey B. Hall, Jeremy Hall, John Hardy, Catharina A. Hartman, Johanna Hass, Sean N. Hatton, Unn K. Haukvik, Katrin Hegenscheid, Andreas Heinz, Ian B. Hickie, Beng Choon Ho, David Hoehn, Pieter J. Hoekstra, Marisa Hollinshead, Avram J. Holmes, Georg Homuth, Martine Hoogman, L. Elliot Hong, Norbert Hosten, Jouke Jan Hottenga, Hilleke E. Hulshoff Pol, Kristy S. Hwang, Clifford R. Jack, Mark Jenkinson, Caroline Johnston, Erik G. Jönsson, René S. Kahn, Dalia Kasperaviciute, Sinead Kelly, Sungeun Kim, Peter Kochunov, Laura Koenders, Bernd Krämer, John B.J. Kwok, Jim Lagopoulos, Gonzalo Laje, Mikael Landen, Bennett A. Landman, John Lauriello, Stephen M. Lawrie, Phil H. Lee, Stephanie Le Hellard, Herve Lemaître, Cassandra D. Leonardo, Chiang shan Li, Benny Liberg, David C. Liewald, Xinmin Liu, Lorna M. Lopez, Eva Loth, Anbarasu Lourdusamy, Michelle Luciano, Fabio Macciardi, Marise W.J. Machielsen, Glenda M. MacQueen, Ulrik F. Malt, René Mandl, Dara S. Manoach, Jean Luc Martinot, Mar Matarin, Karen A. Mather, Manuel Mattheisen, Morten Mattingsdal, Andreas Meyer-Lindenberg, Colm McDonald, Andrew M. McIntosh, Francis J. McMahon, Katie L. McMahon, Eva Meisenzahl, Ingrid Melle, Yuri Milaneschi, Sebastian Mohnke, Grant W. Montgomery, Derek W. Morris, Eric K. Moses, Bryon A. Mueller, Susana Muñoz Maniega, Thomas W. Mühleisen, Bertram Müller-Myhsok, Benson Mwangi, Matthias Nauck, Kwangsik Nho, Thomas E. Nichols, Lars Göran Nilsson, Allison C. Nugent, Lars Nyberg, Rene L. Olvera, Jaap Oosterlaan, Roel A. Ophoff, Massimo Pandolfo, Melina Papalampropoulou-Tsiridou, Martina Papmeyer, Tomas Paus, Zdenka Pausova, Godfrey D. Pearlson, Brenda W. Penninx, Charles P. Peterson, Andrea Pfennig, Mary Phillips, G. Bruce Pike, Jean Baptiste Poline, Steven G. Potkin, Benno Pütz, Adaikalavan Ramasamy, Jerod Rasmussen, Marcella Rietschel, Mark Rijpkema, Shannon L. Risacher, Joshua L. Roffman, Roberto Roiz-Santiañez, Nina Romanczuk-Seiferth, Emma J. Rose, Natalie A. Royle, Dan Rujescu, Mina Ryten, Perminder S. Sachdev, Alireza Salami, Theodore D. Satterthwaite, Jonathan Savitz, Andrew J. Saykin, Cathy Scanlon, Lianne Schmaal, Hugo G. Schnack, Andrew J. Schork, S. Charles Schulz, Remmelt Schür, Larry Seidman, Li Shen, Jody M. Shoemaker, Andrew Simmons, Sanjay M. Sisodiya, Colin Smith, Jordan W. Smoller, Jair C. Soares, Scott R. Sponheim, Emma Sprooten, John M. Starr, Vidar M. Steen, Stephen Strakowski, Lachlan Strike, Jessika Sussmann, Philipp G. Sämann, Alexander Teumer, Arthur W. Toga, Diana Tordesillas-Gutierrez, Daniah Trabzuni, Sarah Trost, Jessica Turner, Martijn Van den Heuvel, Nic J. van der Wee, Kristel van Eijk, Theo G.M. van Erp, Neeltje E.M. van Haren, Dennis van 't Ent, Marie Jose van Tol, Maria C. Valdés Hernández, Dick J. Veltman, Amelia Versace, Henry Völzke, Robert Walker, Henrik Walter, Lei Wang, Joanna M. Wardlaw, Michael E. Weale, Michael W. Weiner, Wei Wen, Lars T. Westlye, Heather C. Whalley, Christopher D. Whelan, Tonya White, Anderson M. Winkler, Katharina Wittfeld, Girma Woldehawariat, Christiane Wolf, David Zilles, Marcel P. Zwiers, Anbupalam Thalamuthu, Peter R. Schofield, Nelson B. Freimer, Natalia S. Lawrence, Wayne Drevets
  • University of Southern California
  • University of California at Los Angeles
  • Queensland Institute of Medical Research
  • Radboud University Nijmegen
  • Institut Pasteur Paris
  • Université Paris Descartes
  • King's College London
  • Karolinska Institutet
  • University of Oslo
  • Dalhousie University
  • Royal College of Surgeons in Ireland
  • McGill University
  • Southwest Foundation for Biomedical Research
  • University of Pittsburgh
  • Brown University
  • Northwestern University
  • University of Iowa
  • University of Greifswald
  • The University of Sydney
  • University of Edinburgh
  • A Platform for Scientific Excellence (SINAPSE) Collaboration
  • Technische Universität Dresden
  • Max Planck Institute of Psychiatry
  • llc.
  • Vrije Universiteit Amsterdam
  • VU University Medical Center
  • Utrecht University
  • Massachusetts General Hospital
  • Harvard University
  • Russian Academy of Sciences
  • University of New Mexico
  • The Mind Research Network
  • University of Galway
  • Cardiff University
  • University of Toronto
  • Stanford University
  • University of Bergen
  • University of Bonn
  • Centre Jülich
  • University of Basel
  • University of Montreal
  • King's Health Partners
  • Hospital Universitario Marques de Valdecilla
  • San Juan de Dios Sanitary Park
  • Université libre de Bruxelles
  • Amsterdam University Medical Centers
  • University of Queensland
  • Trinity College Dublin
  • Charité – Universitätsmedizin Berlin
  • Max Planck Institute for Psycholinguistics
  • Indiana University Bloomington
  • University of Texas Health Science Center at San Antonio
  • Department of Veterans Affairs
  • Icahn School of Medicine at Mount Sinai
  • University of Regensburg
  • Commissariat à l’énergie atomique et aux énergies alternatives
  • University of Vermont
  • Institute of Living
  • Yale University
  • University of Oxford
  • HELIOS-Hospital Stralsund
  • Heidelberg University 
  • University of Göttingen
  • University of Pennsylvania
  • VA Medical Center
  • McMaster University
  • University College London
  • University of Groningen
  • Diakonhjemmet Hospital
  • Maryland Psychiatric Research Center
  • Oakland University
  • Mayo Clinic Rochester, MN
  • South London and Maudsley NHS Foundation Trust
  • Neuroscience Research Australia
  • University of New South Wales
  • Maryland Institute for Neuroscience and Development (MIND)
  • University of Gothenburg
  • Vanderbilt University
  • University of Missouri
  • Broad Institute
  • Université Paris Cité
  • National Institutes of Health
  • Columbia University
  • University of Nottingham
  • University of California at Irvine
  • University of Milan
  • University of Calgary
  • Aarhus University
  • Sorlandet Hospital HF
  • Ludwig Maximilian University of Munich
  • Centre for Genetic Origins of Health and Disease
  • Fairview Health Service
  • Munich Cluster for Systems Neurology (SyNergy)
  • University of Texas Health Science Center at Houston
  • Warwick Manufacturing Group
  • Stockholm University
  • Stockholm Brain Institute
  • Umeå University
  • University of California at Berkeley
  • RTI International
  • Martin Luther University Halle-Wittenberg
  • Prince of Wales Hospital
  • Laureate Institute for Brain Research
  • University of Tulsa
  • University of California at San Diego
  • Beth Israel Deaconess Medical Center
  • University of Cincinnati
  • King Faisal Specialist Hospital and Research Centre
  • Georgia State University
  • Leiden University
  • Humboldt University of Berlin
  • University of California at San Francisco
  • Erasmus University Rotterdam
  • University of Exeter
  • Johnson & Johnson

Research output: Contribution to journalArticlepeer-review

Abstract

The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. Organized into Working Groups that tackle questions in neuroscience, genetics, and medicine, ENIGMA studies have analyzed neuroimaging data from over 12,826 subjects. In addition, data from 12,171 individuals were provided by the CHARGE consortium for replication of findings, in a total of 24,997 subjects. By meta-analyzing results from many sites, ENIGMA has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected. ENIGMA's first project was a genome-wide association study identifying common variants in the genome associated with hippocampal volume or intracranial volume. Continuing work is exploring genetic associations with subcortical volumes (ENIGMA2) and white matter microstructure (ENIGMA-DTI). Working groups also focus on understanding how schizophrenia, bipolar illness, major depression and attention deficit/hyperactivity disorder (ADHD) affect the brain. We review the current progress of the ENIGMA Consortium, along with challenges and unexpected discoveries made on the way.

Original languageEnglish
Pages (from-to)153-182
Number of pages30
JournalBrain Imaging and Behavior
Volume8
Issue number2
DOIs
Publication statusPublished - Jun 2014
Externally publishedYes

Keywords

  • Consortium
  • GWAS
  • Genetics
  • MRI
  • Meta-analysis
  • Multi-site

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