TY - JOUR
T1 - The Burden of Dementia due to Down Syndrome, Parkinson's Disease, Stroke, and Traumatic Brain Injury
T2 - A Systematic Analysis for the Global Burden of Disease Study 2019
AU - GBD 2019 Dementia Collaborators
AU - Nichols, Emma
AU - Abd-Allah, Foad
AU - Abdoli, Amir
AU - Abu-Gharbieh, Eman
AU - Adelson, Jaimie D.
AU - Akinyemi, Rufus Olusola
AU - Alanezi, Fahad Mashhour
AU - Alipour, Vahid
AU - Arabloo, Jalal
AU - Ayano, Getinet
AU - Baig, Atif Amin
AU - Banach, Maciej
AU - Barboza, Miguel A.
AU - Barker-Collo, Suzanne Lyn
AU - Baune, Bernhard T.
AU - Bhagavathula, Akshaya Srikanth
AU - Bhattacharyya, Krittika
AU - Bijani, Ali
AU - Biondi, Antonio
AU - Biswas, Atanu
AU - Bolla, Srinivasa Rao
AU - Boloor, Archith
AU - Brayne, Carol
AU - Brenner, Hermann
AU - Burkart, Katrin
AU - Burns, Richard A.
AU - Nagaraja, Sharath Burugina
AU - Camera, Luis Alberto
AU - Carvalho, Felix
AU - Castro-de-Araujo, Luis F. S.
AU - Cerin, Ester
AU - Cernigliaro, Achille
AU - Cherbuin, Nicolas
AU - Choi, Jee-Young Jasmine
AU - Chu, Dinh-Toi
AU - Couto, Rosa A. S.
AU - Dagnew, Baye
AU - Dang, Anh Kim
AU - Diaz, Daniel
AU - Forooshani, Zahra Sadat Dibaji
AU - Djalalinia, Shirin
AU - Doku, Paul Narh
AU - El-Jaafary, Shaimaa I.
AU - Eskandari, Khalil
AU - Eskandarieh, Sharareh
AU - Farzadfar, Farshad
AU - Feigin, Valery L.
AU - Fereshtehnejad, Seyed-Mohammad
AU - Fernandes, Eduarda
AU - Househ, Mowafa
PY - 2021/1/27
Y1 - 2021/1/27
N2 - Background: In light of the increasing trend in the global number of individuals affected by dementia and the lack of any available disease-modifying therapies, it is necessary to fully understand and quantify the global burden of dementia. This work aimed to estimate the proportion of dementia due to Down syndrome, Parkinson's disease, clinical stroke, and traumatic brain injury (TBI), globally and by world region, in order to better understand the contribution of clinical diseases to dementia prevalence. Methods: Through literature review, we obtained data on the relative risk of dementia with each condition and estimated relative risks by age using a Bayesian meta-regression tool. We then calculated population attributable fractions (PAFs), or the proportion of dementia attributable to each condition, using the estimates of relative risk and prevalence estimates for each condition from the Global Burden of Disease Study 2019. Finally, we multiplied these estimates by dementia prevalence to calculate the number of dementia cases attributable to each condition. Findings: For each clinical condition, the relative risk of dementia decreased with age. Relative risks were highest for Down syndrome, followed by Parkinson's disease, stroke, and TBI. However, due to the high prevalence of stroke, the PAF for dementia due to stroke was highest. Together, Down syndrome, Parkinson's disease, stroke, and TBI explained 10.0% (95% UI: 6.0-16.5) of the global prevalence of dementia. Interpretation: Ten percent of dementia prevalence globally could be explained by Down syndrome, Parkinson's disease, stroke, and TBI. The quantification of the proportion of dementia attributable to these 4 conditions constitutes a small contribution to our overall understanding of what causes dementia. However, epidemiological research into modifiable risk factors as well as basic science research focused on elucidating intervention approaches to prevent or delay the neuropathological changes that commonly characterize dementia will be critically important in future efforts to prevent and treat disease.
AB - Background: In light of the increasing trend in the global number of individuals affected by dementia and the lack of any available disease-modifying therapies, it is necessary to fully understand and quantify the global burden of dementia. This work aimed to estimate the proportion of dementia due to Down syndrome, Parkinson's disease, clinical stroke, and traumatic brain injury (TBI), globally and by world region, in order to better understand the contribution of clinical diseases to dementia prevalence. Methods: Through literature review, we obtained data on the relative risk of dementia with each condition and estimated relative risks by age using a Bayesian meta-regression tool. We then calculated population attributable fractions (PAFs), or the proportion of dementia attributable to each condition, using the estimates of relative risk and prevalence estimates for each condition from the Global Burden of Disease Study 2019. Finally, we multiplied these estimates by dementia prevalence to calculate the number of dementia cases attributable to each condition. Findings: For each clinical condition, the relative risk of dementia decreased with age. Relative risks were highest for Down syndrome, followed by Parkinson's disease, stroke, and TBI. However, due to the high prevalence of stroke, the PAF for dementia due to stroke was highest. Together, Down syndrome, Parkinson's disease, stroke, and TBI explained 10.0% (95% UI: 6.0-16.5) of the global prevalence of dementia. Interpretation: Ten percent of dementia prevalence globally could be explained by Down syndrome, Parkinson's disease, stroke, and TBI. The quantification of the proportion of dementia attributable to these 4 conditions constitutes a small contribution to our overall understanding of what causes dementia. However, epidemiological research into modifiable risk factors as well as basic science research focused on elucidating intervention approaches to prevent or delay the neuropathological changes that commonly characterize dementia will be critically important in future efforts to prevent and treat disease.
KW - Burden of disease
KW - Dementia
KW - Global health
KW - Meta-analysis
KW - Public health
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=hbku_researchportal&SrcAuth=WosAPI&KeyUT=WOS:000675325100005&DestLinkType=FullRecord&DestApp=WOS_CPL
U2 - 10.1159/000515393
DO - 10.1159/000515393
M3 - Article
C2 - 34182555
SN - 0251-5350
VL - 55
SP - 286
EP - 296
JO - Neuroepidemiology
JF - Neuroepidemiology
IS - 4
ER -