The 3p21.1-p21.3 hereditary vascular retinopathy locus increases the risk for Raynaud's phenomenon and migraine

J. J. Hottenga; K. R.J. Vanmolkot; E. E. Kors; S. Kheradmand Kia; P. T.V.M. De Jong; J. Haan; G. M. Terwindt; R. R. Frants; M. D. Ferrari; A. M.J.M. Van Den Maagdenberg

doi:10.1111/j.1468-2982.2005.00994.x

The 3p21.1-p21.3 hereditary vascular retinopathy locus increases the risk for Raynaud's phenomenon and migraine

J. J. Hottenga
, K. R.J. Vanmolkot
, E. E. Kors
, S. Kheradmand Kia
, P. T.V.M. De Jong
, J. Haan
, G. M. Terwindt
, R. R. Frants
, M. D. Ferrari
, A. M.J.M. Van Den Maagdenberg^*

^*Corresponding author for this work

Leiden University
Netherlands Institute for Neuroscience
Amsterdam University Medical Centers
Erasmus University Rotterdam
Rijnland Hospital

Research output: Contribution to journal › Article › peer-review

Abstract

Previously, we described a large Dutch family with hereditary vascular retinopathy (HVR), Raynaud's phenomenon and migraine. A locus for HVR was mapped on chromosome 3p21.1-p21.3, but the gene has not yet been identified. The fact that all three disorders share a vascular aetiology prompted us to study whether the HVR haplotype also contributed to Raynaud's phenomenon and migraine in this family. Whereas the parent-child transmission disequilibrium test (TDT) did not reach significance, the sibling TDT revealed that the HVR haplotype harbours a susceptibility factor for Raynaud's phenomenon and migraine. Identification of the HVR gene will improve the understanding of the pathophysiology of HVR, Raynaud's phenomenon and migraine.

Original language	English
Pages (from-to)	1168-1172
Number of pages	5
Journal	Cephalalgia
Volume	25
Issue number	12
DOIs	https://doi.org/10.1111/j.1468-2982.2005.00994.x
Publication status	Published - Dec 2005
Externally published	Yes

Keywords

Hereditary vascular retinopathy
Locus
Migraine
Raynaud's phenomenon

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10.1111/j.1468-2982.2005.00994.x

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Hottenga, J. J., Vanmolkot, K. R. J., Kors, E. E., Kia, S. K., De Jong, P. T. V. M., Haan, J., Terwindt, G. M., Frants, R. R., Ferrari, M. D., & Van Den Maagdenberg, A. M. J. M. (2005). The 3p21.1-p21.3 hereditary vascular retinopathy locus increases the risk for Raynaud's phenomenon and migraine. Cephalalgia, 25(12), 1168-1172. https://doi.org/10.1111/j.1468-2982.2005.00994.x

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title = "The 3p21.1-p21.3 hereditary vascular retinopathy locus increases the risk for Raynaud's phenomenon and migraine",

abstract = "Previously, we described a large Dutch family with hereditary vascular retinopathy (HVR), Raynaud's phenomenon and migraine. A locus for HVR was mapped on chromosome 3p21.1-p21.3, but the gene has not yet been identified. The fact that all three disorders share a vascular aetiology prompted us to study whether the HVR haplotype also contributed to Raynaud's phenomenon and migraine in this family. Whereas the parent-child transmission disequilibrium test (TDT) did not reach significance, the sibling TDT revealed that the HVR haplotype harbours a susceptibility factor for Raynaud's phenomenon and migraine. Identification of the HVR gene will improve the understanding of the pathophysiology of HVR, Raynaud's phenomenon and migraine.",

keywords = "Hereditary vascular retinopathy, Locus, Migraine, Raynaud's phenomenon",

author = "Hottenga, \{J. J.\} and Vanmolkot, \{K. R.J.\} and Kors, \{E. E.\} and Kia, \{S. Kheradmand\} and \{De Jong\}, \{P. T.V.M.\} and J. Haan and Terwindt, \{G. M.\} and Frants, \{R. R.\} and Ferrari, \{M. D.\} and \{Van Den Maagdenberg\}, \{A. M.J.M.\}",

year = "2005",

month = dec,

doi = "10.1111/j.1468-2982.2005.00994.x",

language = "English",

volume = "25",

pages = "1168--1172",

journal = "Cephalalgia",

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TY - JOUR

T1 - The 3p21.1-p21.3 hereditary vascular retinopathy locus increases the risk for Raynaud's phenomenon and migraine

AU - Hottenga, J. J.

AU - Vanmolkot, K. R.J.

AU - Kors, E. E.

AU - Kia, S. Kheradmand

AU - De Jong, P. T.V.M.

AU - Haan, J.

AU - Terwindt, G. M.

AU - Frants, R. R.

AU - Ferrari, M. D.

AU - Van Den Maagdenberg, A. M.J.M.

PY - 2005/12

Y1 - 2005/12

N2 - Previously, we described a large Dutch family with hereditary vascular retinopathy (HVR), Raynaud's phenomenon and migraine. A locus for HVR was mapped on chromosome 3p21.1-p21.3, but the gene has not yet been identified. The fact that all three disorders share a vascular aetiology prompted us to study whether the HVR haplotype also contributed to Raynaud's phenomenon and migraine in this family. Whereas the parent-child transmission disequilibrium test (TDT) did not reach significance, the sibling TDT revealed that the HVR haplotype harbours a susceptibility factor for Raynaud's phenomenon and migraine. Identification of the HVR gene will improve the understanding of the pathophysiology of HVR, Raynaud's phenomenon and migraine.

AB - Previously, we described a large Dutch family with hereditary vascular retinopathy (HVR), Raynaud's phenomenon and migraine. A locus for HVR was mapped on chromosome 3p21.1-p21.3, but the gene has not yet been identified. The fact that all three disorders share a vascular aetiology prompted us to study whether the HVR haplotype also contributed to Raynaud's phenomenon and migraine in this family. Whereas the parent-child transmission disequilibrium test (TDT) did not reach significance, the sibling TDT revealed that the HVR haplotype harbours a susceptibility factor for Raynaud's phenomenon and migraine. Identification of the HVR gene will improve the understanding of the pathophysiology of HVR, Raynaud's phenomenon and migraine.

KW - Hereditary vascular retinopathy

KW - Locus

KW - Migraine

KW - Raynaud's phenomenon

UR - https://www.scopus.com/pages/publications/28844498374

U2 - 10.1111/j.1468-2982.2005.00994.x

DO - 10.1111/j.1468-2982.2005.00994.x

M3 - Article

C2 - 16305605

AN - SCOPUS:28844498374

SN - 0333-1024

VL - 25

SP - 1168

EP - 1172

JO - Cephalalgia

JF - Cephalalgia

IS - 12

ER -

The 3p21.1-p21.3 hereditary vascular retinopathy locus increases the risk for Raynaud's phenomenon and migraine

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Keywords

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