Signal transduction in neutrophil chemotaxis

V. L. Katanaev

doi:10.1023/A:1010293809553

Signal transduction in neutrophil chemotaxis

V. L. Katanaev^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

59 Citations (Scopus)

Abstract

This review discusses current knowledge on signal transduction pathways controlling chemotaxis of neutrophils and similar cells. Most neutrophil chemoattractants bind to seven-transmembrane-helix receptors. These receptors activate trimeric G proteins of the G_i class in neutrophils to initiate chemotaxis. Phospholipases Cβ, phosphoinositide 3-kinase γ, and PH domain-containing proteins play various roles in signaling further downstream. The actin cytoskeleton is crucial for cell motility, and is controlled by Rho family GTP-binding proteins. PIP 5-kinase, LIM kinase, myosin light chain kinase and phosphatase, or WASP-like proteins may be important links between Rho GTPases and actin during chemotaxis. Newly emerging ideas on the regulation of the "compass" of chemotaxing cells, which may involve Cdc42 and certain PH domain containing proteins, are also presented.

Original language	English
Pages (from-to)	351-368
Number of pages	18
Journal	Biochemistry (Moscow)
Volume	66
Issue number	4
DOIs	https://doi.org/10.1023/A:1010293809553
Publication status	Published - Apr 2001
Externally published	Yes

Keywords

Actin polymerization
G protein-coupled receptors
Neutrophil chemotaxis
PI3 kinases
Rho family proteins
Signal transduction

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title = "Signal transduction in neutrophil chemotaxis",

abstract = "This review discusses current knowledge on signal transduction pathways controlling chemotaxis of neutrophils and similar cells. Most neutrophil chemoattractants bind to seven-transmembrane-helix receptors. These receptors activate trimeric G proteins of the Gi class in neutrophils to initiate chemotaxis. Phospholipases Cβ, phosphoinositide 3-kinase γ, and PH domain-containing proteins play various roles in signaling further downstream. The actin cytoskeleton is crucial for cell motility, and is controlled by Rho family GTP-binding proteins. PIP 5-kinase, LIM kinase, myosin light chain kinase and phosphatase, or WASP-like proteins may be important links between Rho GTPases and actin during chemotaxis. Newly emerging ideas on the regulation of the {"}compass{"} of chemotaxing cells, which may involve Cdc42 and certain PH domain containing proteins, are also presented.",

keywords = "Actin polymerization, G protein-coupled receptors, Neutrophil chemotaxis, PI3 kinases, Rho family proteins, Signal transduction",

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language = "English",

volume = "66",

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T1 - Signal transduction in neutrophil chemotaxis

AU - Katanaev, V. L.

PY - 2001/4

Y1 - 2001/4

N2 - This review discusses current knowledge on signal transduction pathways controlling chemotaxis of neutrophils and similar cells. Most neutrophil chemoattractants bind to seven-transmembrane-helix receptors. These receptors activate trimeric G proteins of the Gi class in neutrophils to initiate chemotaxis. Phospholipases Cβ, phosphoinositide 3-kinase γ, and PH domain-containing proteins play various roles in signaling further downstream. The actin cytoskeleton is crucial for cell motility, and is controlled by Rho family GTP-binding proteins. PIP 5-kinase, LIM kinase, myosin light chain kinase and phosphatase, or WASP-like proteins may be important links between Rho GTPases and actin during chemotaxis. Newly emerging ideas on the regulation of the "compass" of chemotaxing cells, which may involve Cdc42 and certain PH domain containing proteins, are also presented.

AB - This review discusses current knowledge on signal transduction pathways controlling chemotaxis of neutrophils and similar cells. Most neutrophil chemoattractants bind to seven-transmembrane-helix receptors. These receptors activate trimeric G proteins of the Gi class in neutrophils to initiate chemotaxis. Phospholipases Cβ, phosphoinositide 3-kinase γ, and PH domain-containing proteins play various roles in signaling further downstream. The actin cytoskeleton is crucial for cell motility, and is controlled by Rho family GTP-binding proteins. PIP 5-kinase, LIM kinase, myosin light chain kinase and phosphatase, or WASP-like proteins may be important links between Rho GTPases and actin during chemotaxis. Newly emerging ideas on the regulation of the "compass" of chemotaxing cells, which may involve Cdc42 and certain PH domain containing proteins, are also presented.

KW - Actin polymerization

KW - G protein-coupled receptors

KW - Neutrophil chemotaxis

KW - PI3 kinases

KW - Rho family proteins

KW - Signal transduction

UR - https://www.scopus.com/pages/publications/0035297563

U2 - 10.1023/A:1010293809553

DO - 10.1023/A:1010293809553

M3 - Review article

C2 - 11403641

AN - SCOPUS:0035297563

SN - 0006-2979

VL - 66

SP - 351

EP - 368

JO - Biochemistry (Moscow)

JF - Biochemistry (Moscow)

IS - 4

ER -

Signal transduction in neutrophil chemotaxis

Abstract

Keywords

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