Sex-related differences in muscle deoxygenation during ramp incremental exercise

Juan M. Murias; Daniel A. Keir; Matthew D. Spencer; Donald H. Paterson

doi:10.1016/j.resp.2013.08.011

Sex-related differences in muscle deoxygenation during ramp incremental exercise

Juan M. Murias, Daniel A. Keir, Matthew D. Spencer, Donald H. Paterson^*

^*Corresponding author for this work

Western University

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Abstract

Sex-specific differences in the temporal profiles of fractional O₂ extraction during incremental cycling were examined using changes in near-infrared spectroscopy (NIRS)-derived muscle deoxygenated hemoglobin concentration (δ[HHb]) and breath-by-breath pulmonary O₂ uptake (V̇O2p) measurements. Subject's (men: n=10; women: n=10) δ[HHb] data were normalized to 100% of the response, plotted as a function V̇O2p, %V̇O2p, power output (PO), and % PO, and fit with a piecewise double-linear regression model. The slope of the first segment of the double linear model was significantly greater in women compared to men when %δ[HHb] was plotted as a function of V̇O2p, %V̇O2p and PO (p<0.05). Both sexes displayed a near-plateau in the %δ[HHb] which occurred at an exercise intensity near the respiratory compensation point. Thus, young women display a poorer ability to deliver O₂ to the exercising tissue compared to men and oxidative demands must be supplemented by a greater fractional O₂ extraction.

Original language	English
Pages (from-to)	530-536
Number of pages	7
Journal	Respiratory Physiology and Neurobiology
Volume	189
Issue number	3
DOIs	https://doi.org/10.1016/j.resp.2013.08.011
Publication status	Published - 1 Dec 2013
Externally published	Yes

Keywords

Cycling
Near-infrared spectroscopy
Oxygen extraction

Access to Document

10.1016/j.resp.2013.08.011

Cite this

@article{c74f64be045744a49846cad6e732b1b2,

title = "Sex-related differences in muscle deoxygenation during ramp incremental exercise",

abstract = "Sex-specific differences in the temporal profiles of fractional O2 extraction during incremental cycling were examined using changes in near-infrared spectroscopy (NIRS)-derived muscle deoxygenated hemoglobin concentration (δ[HHb]) and breath-by-breath pulmonary O2 uptake ({\.V}O2p) measurements. Subject's (men: n=10; women: n=10) δ[HHb] data were normalized to 100\% of the response, plotted as a function {\.V}O2p, \%{\.V}O2p, power output (PO), and \% PO, and fit with a piecewise double-linear regression model. The slope of the first segment of the double linear model was significantly greater in women compared to men when \%δ[HHb] was plotted as a function of {\.V}O2p, \%{\.V}O2p and PO (p<0.05). Both sexes displayed a near-plateau in the \%δ[HHb] which occurred at an exercise intensity near the respiratory compensation point. Thus, young women display a poorer ability to deliver O2 to the exercising tissue compared to men and oxidative demands must be supplemented by a greater fractional O2 extraction.",

keywords = "Cycling, Near-infrared spectroscopy, Oxygen extraction",

author = "Murias, \{Juan M.\} and Keir, \{Daniel A.\} and Spencer, \{Matthew D.\} and Paterson, \{Donald H.\}",

year = "2013",

month = dec,

day = "1",

doi = "10.1016/j.resp.2013.08.011",

language = "English",

volume = "189",

pages = "530--536",

journal = "Respiratory Physiology and Neurobiology",

issn = "1569-9048",

publisher = "Elsevier B.V.",

number = "3",

}

TY - JOUR

T1 - Sex-related differences in muscle deoxygenation during ramp incremental exercise

AU - Murias, Juan M.

AU - Keir, Daniel A.

AU - Spencer, Matthew D.

AU - Paterson, Donald H.

PY - 2013/12/1

Y1 - 2013/12/1

N2 - Sex-specific differences in the temporal profiles of fractional O2 extraction during incremental cycling were examined using changes in near-infrared spectroscopy (NIRS)-derived muscle deoxygenated hemoglobin concentration (δ[HHb]) and breath-by-breath pulmonary O2 uptake (V̇O2p) measurements. Subject's (men: n=10; women: n=10) δ[HHb] data were normalized to 100% of the response, plotted as a function V̇O2p, %V̇O2p, power output (PO), and % PO, and fit with a piecewise double-linear regression model. The slope of the first segment of the double linear model was significantly greater in women compared to men when %δ[HHb] was plotted as a function of V̇O2p, %V̇O2p and PO (p<0.05). Both sexes displayed a near-plateau in the %δ[HHb] which occurred at an exercise intensity near the respiratory compensation point. Thus, young women display a poorer ability to deliver O2 to the exercising tissue compared to men and oxidative demands must be supplemented by a greater fractional O2 extraction.

AB - Sex-specific differences in the temporal profiles of fractional O2 extraction during incremental cycling were examined using changes in near-infrared spectroscopy (NIRS)-derived muscle deoxygenated hemoglobin concentration (δ[HHb]) and breath-by-breath pulmonary O2 uptake (V̇O2p) measurements. Subject's (men: n=10; women: n=10) δ[HHb] data were normalized to 100% of the response, plotted as a function V̇O2p, %V̇O2p, power output (PO), and % PO, and fit with a piecewise double-linear regression model. The slope of the first segment of the double linear model was significantly greater in women compared to men when %δ[HHb] was plotted as a function of V̇O2p, %V̇O2p and PO (p<0.05). Both sexes displayed a near-plateau in the %δ[HHb] which occurred at an exercise intensity near the respiratory compensation point. Thus, young women display a poorer ability to deliver O2 to the exercising tissue compared to men and oxidative demands must be supplemented by a greater fractional O2 extraction.

KW - Cycling

KW - Near-infrared spectroscopy

KW - Oxygen extraction

UR - https://www.scopus.com/pages/publications/84887999216

U2 - 10.1016/j.resp.2013.08.011

DO - 10.1016/j.resp.2013.08.011

M3 - Article

C2 - 23994824

AN - SCOPUS:84887999216

SN - 1569-9048

VL - 189

SP - 530

EP - 536

JO - Respiratory Physiology and Neurobiology

JF - Respiratory Physiology and Neurobiology

IS - 3

ER -

Sex-related differences in muscle deoxygenation during ramp incremental exercise

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this