SARS-CoV-2 entry in host cells-multiple targets for treatment and prevention

Ismail Sami Mahmoud; Yazun Bashir Jarrar; Walhan Alshaer; Said Ismail

doi:10.1016/j.biochi.2020.05.012

SARS-CoV-2 entry in host cells-multiple targets for treatment and prevention

Ismail Sami Mahmoud^*
, Yazun Bashir Jarrar
, Walhan Alshaer
, Said Ismail

^*Corresponding author for this work

Hashemite University
Al-Zaytoonah University of Jordan
University of Jordan
Qatar Foundation HQ

Research output: Contribution to journal › Short survey › peer-review

74 Citations (Scopus)

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new viral disease that has gained global attention owing to its ability to provoke community and health-care-associated outbreaks of severe infections in human populations. The virus poses serious challenges to clinical management because there are still no approved anti- SARS-CoV-2 drugs available. In this mini-review, we summarize the much updated published reports that demonstrate the mechanism of SARS-CoV-2 entry into host cells, and discuss the availability and development of attractive host-based therapeutic options for SARS-CoV-2 infections.

Original language	English
Pages (from-to)	93-98
Number of pages	6
Journal	Biochimie
Volume	175
DOIs	https://doi.org/10.1016/j.biochi.2020.05.012
Publication status	Published - Aug 2020
Externally published	Yes

Keywords

ACE2
Drugs
Entry
Proteases
SARS-CoV-2

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10.1016/j.biochi.2020.05.012

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title = "SARS-CoV-2 entry in host cells-multiple targets for treatment and prevention",

abstract = "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new viral disease that has gained global attention owing to its ability to provoke community and health-care-associated outbreaks of severe infections in human populations. The virus poses serious challenges to clinical management because there are still no approved anti- SARS-CoV-2 drugs available. In this mini-review, we summarize the much updated published reports that demonstrate the mechanism of SARS-CoV-2 entry into host cells, and discuss the availability and development of attractive host-based therapeutic options for SARS-CoV-2 infections.",

keywords = "ACE2, Drugs, Entry, Proteases, SARS-CoV-2",

author = "Mahmoud, \{Ismail Sami\} and Jarrar, \{Yazun Bashir\} and Walhan Alshaer and Said Ismail",

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year = "2020",

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doi = "10.1016/j.biochi.2020.05.012",

language = "English",

volume = "175",

pages = "93--98",

journal = "Biochimie",

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TY - JOUR

T1 - SARS-CoV-2 entry in host cells-multiple targets for treatment and prevention

AU - Mahmoud, Ismail Sami

AU - Jarrar, Yazun Bashir

AU - Alshaer, Walhan

AU - Ismail, Said

PY - 2020/8

Y1 - 2020/8

N2 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new viral disease that has gained global attention owing to its ability to provoke community and health-care-associated outbreaks of severe infections in human populations. The virus poses serious challenges to clinical management because there are still no approved anti- SARS-CoV-2 drugs available. In this mini-review, we summarize the much updated published reports that demonstrate the mechanism of SARS-CoV-2 entry into host cells, and discuss the availability and development of attractive host-based therapeutic options for SARS-CoV-2 infections.

AB - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new viral disease that has gained global attention owing to its ability to provoke community and health-care-associated outbreaks of severe infections in human populations. The virus poses serious challenges to clinical management because there are still no approved anti- SARS-CoV-2 drugs available. In this mini-review, we summarize the much updated published reports that demonstrate the mechanism of SARS-CoV-2 entry into host cells, and discuss the availability and development of attractive host-based therapeutic options for SARS-CoV-2 infections.

KW - ACE2

KW - Drugs

KW - Entry

KW - Proteases

KW - SARS-CoV-2

UR - https://www.scopus.com/pages/publications/85085772600

U2 - 10.1016/j.biochi.2020.05.012

DO - 10.1016/j.biochi.2020.05.012

M3 - Short survey

C2 - 32479856

AN - SCOPUS:85085772600

SN - 0300-9084

VL - 175

SP - 93

EP - 98

JO - Biochimie

JF - Biochimie

ER -

SARS-CoV-2 entry in host cells-multiple targets for treatment and prevention

Abstract

Keywords

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