TY - JOUR
T1 - Responders and non-responders to aerobic exercise training
T2 - beyond the evaluation of V˙O2max
AU - Mattioni Maturana, Felipe
AU - Soares, Rogerio N.
AU - Murias, Juan M.
AU - Schellhorn, Philipp
AU - Erz, Gunnar
AU - Burgstahler, Christof
AU - Widmann, Manuel
AU - Munz, Barbara
AU - Thiel, Ansgar
AU - Nieß, Andreas M.
N1 - Publisher Copyright:
© 2021 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.
PY - 2021/8
Y1 - 2021/8
N2 - The evaluation of the maximal oxygen uptake ((Formula presented.)) following exercise training is the classical assessment of training effectiveness. Research has lacked in investigating whether individuals that do not respond to the training intervention ((Formula presented.)), also do not improve in other health-related parameters. We aimed to investigate the cardiovascular and metabolic adaptations (i.e., performance, body composition, blood pressure, vascular function, fasting blood markers, and resting cardiac function and morphology) to exercise training among participants who showed different levels of (Formula presented.) responsiveness. Healthy sedentary participants engaged in a 6-week exercise training program, three times a week. Our results showed that responders had a greater increase in peak power output, second lactate threshold, and microvascular responsiveness, whereas non-responders had a greater increase in cycling efficiency. No statistical differences were observed in body composition, blood pressure, fasting blood parameters, and resting cardiac adaptations. In conclusion, our study showed, for the first time, that in addition to the differences in the (Formula presented.), a greater increase in microvascular responsiveness in responders compared to non-responders was observed. Additionally, responders and non-responders did not show differences in the adaptations on metabolic parameters. There is an increasing need for personalized training prescription, depending on the target clinical outcome.
AB - The evaluation of the maximal oxygen uptake ((Formula presented.)) following exercise training is the classical assessment of training effectiveness. Research has lacked in investigating whether individuals that do not respond to the training intervention ((Formula presented.)), also do not improve in other health-related parameters. We aimed to investigate the cardiovascular and metabolic adaptations (i.e., performance, body composition, blood pressure, vascular function, fasting blood markers, and resting cardiac function and morphology) to exercise training among participants who showed different levels of (Formula presented.) responsiveness. Healthy sedentary participants engaged in a 6-week exercise training program, three times a week. Our results showed that responders had a greater increase in peak power output, second lactate threshold, and microvascular responsiveness, whereas non-responders had a greater increase in cycling efficiency. No statistical differences were observed in body composition, blood pressure, fasting blood parameters, and resting cardiac adaptations. In conclusion, our study showed, for the first time, that in addition to the differences in the (Formula presented.), a greater increase in microvascular responsiveness in responders compared to non-responders was observed. Additionally, responders and non-responders did not show differences in the adaptations on metabolic parameters. There is an increasing need for personalized training prescription, depending on the target clinical outcome.
KW - cardiovascular
KW - exercise training
KW - health
KW - responders
UR - https://www.scopus.com/pages/publications/85113396314
U2 - 10.14814/phy2.14951
DO - 10.14814/phy2.14951
M3 - Article
C2 - 34409753
AN - SCOPUS:85113396314
SN - 2051-817X
VL - 9
JO - Physiological Reports
JF - Physiological Reports
IS - 16
M1 - e14951
ER -