Reproducibility study of the pharmacokinetics of amikacin, gentamicin and tobramycin; a three-way crossover study

A. Dyas; R. Wise; J. Pijck; Th Hallynck; J. Acar; D. Adam; R. Cadorniga; M. Wenk; H. H. Soep

doi:10.1093/jac/12.4.371

Reproducibility study of the pharmacokinetics of amikacin, gentamicin and tobramycin; a three-way crossover study

A. Dyas
, R. Wise^*
, J. Pijck
, Th Hallynck
, J. Acar
, D. Adam
, R. Cadorniga
, M. Wenk
, H. H. Soep

^*Corresponding author for this work

Sandwell and West Birmingham Hospitals NHS Trust
Farmaceutisch Institut
Hôpital Saint-Joseph
Ludwig Maximilian University of Munich
Complutense University
Kantonspital
Bristol Myers Company

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

The hypothesis that the pharmacokinetics of amikacin are more predictable than those of gentamicin or tobramycin was studied.In a three-way crossover design 58 volunteers received 7.5 mg/kg amikacin by iv infusion and either 1.5 mg/kg or 1 mg/kg gentamicin and tobramycin. The mean half-life and mean serum concentration at 1 h for each drug was determined. No consistent significant difference was found between the pharmacokinetics of amikacin and the other two drugs.

Original language	English
Pages (from-to)	371-376
Number of pages	6
Journal	Journal of Antimicrobial Chemotherapy
Volume	12
Issue number	4
DOIs	https://doi.org/10.1093/jac/12.4.371
Publication status	Published - Oct 1983
Externally published	Yes

Access to Document

10.1093/jac/12.4.371

Cite this

@article{6f9a9d3c763a4d159a64acc5b95715f1,

title = "Reproducibility study of the pharmacokinetics of amikacin, gentamicin and tobramycin; a three-way crossover study",

abstract = "The hypothesis that the pharmacokinetics of amikacin are more predictable than those of gentamicin or tobramycin was studied.In a three-way crossover design 58 volunteers received 7.5 mg/kg amikacin by iv infusion and either 1.5 mg/kg or 1 mg/kg gentamicin and tobramycin. The mean half-life and mean serum concentration at 1 h for each drug was determined. No consistent significant difference was found between the pharmacokinetics of amikacin and the other two drugs.",

author = "A. Dyas and R. Wise and J. Pijck and Th Hallynck and J. Acar and D. Adam and R. Cadorniga and M. Wenk and Soep, \{H. H.\}",

year = "1983",

month = oct,

doi = "10.1093/jac/12.4.371",

language = "English",

volume = "12",

pages = "371--376",

journal = "Journal of Antimicrobial Chemotherapy",

issn = "0305-7453",

publisher = "Oxford University Press",

number = "4",

}

TY - JOUR

T1 - Reproducibility study of the pharmacokinetics of amikacin, gentamicin and tobramycin; a three-way crossover study

AU - Dyas, A.

AU - Wise, R.

AU - Pijck, J.

AU - Hallynck, Th

AU - Acar, J.

AU - Adam, D.

AU - Cadorniga, R.

AU - Wenk, M.

AU - Soep, H. H.

PY - 1983/10

Y1 - 1983/10

N2 - The hypothesis that the pharmacokinetics of amikacin are more predictable than those of gentamicin or tobramycin was studied.In a three-way crossover design 58 volunteers received 7.5 mg/kg amikacin by iv infusion and either 1.5 mg/kg or 1 mg/kg gentamicin and tobramycin. The mean half-life and mean serum concentration at 1 h for each drug was determined. No consistent significant difference was found between the pharmacokinetics of amikacin and the other two drugs.

AB - The hypothesis that the pharmacokinetics of amikacin are more predictable than those of gentamicin or tobramycin was studied.In a three-way crossover design 58 volunteers received 7.5 mg/kg amikacin by iv infusion and either 1.5 mg/kg or 1 mg/kg gentamicin and tobramycin. The mean half-life and mean serum concentration at 1 h for each drug was determined. No consistent significant difference was found between the pharmacokinetics of amikacin and the other two drugs.

UR - https://www.scopus.com/pages/publications/0021079882

U2 - 10.1093/jac/12.4.371

DO - 10.1093/jac/12.4.371

M3 - Article

C2 - 6643332

AN - SCOPUS:0021079882

SN - 0305-7453

VL - 12

SP - 371

EP - 376

JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

IS - 4

ER -

Reproducibility study of the pharmacokinetics of amikacin, gentamicin and tobramycin; a three-way crossover study

Abstract

Access to Document

Other files and links

Fingerprint

Cite this