Proteomic understanding of SARS-CoV-2 infection and COVID-19: Biological, diagnostic, and therapeutic perspectives

Fares Al-Ejeh; Maysaloun Merhi; Mariam Al-Muftah; Queenie Fernandes; Lobna Al-Zaidan; Takwa Bedhiafi; Sarra Mestiri; Dina Moustafa; Nassiba Taib; Varghese Inchakalody; Afsheen Raza; Shahab Uddin; Said Dermime

doi:10.1016/B978-0-323-91794-0.00002-0

Proteomic understanding of SARS-CoV-2 infection and COVID-19: Biological, diagnostic, and therapeutic perspectives

Fares Al-Ejeh
, Maysaloun Merhi
, Mariam Al-Muftah
, Queenie Fernandes
, Lobna Al-Zaidan
, Takwa Bedhiafi
, Sarra Mestiri
, Dina Moustafa
, Nassiba Taib
, Varghese Inchakalody
, Afsheen Raza
, Shahab Uddin
, Said Dermime

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Citation (Scopus)

Abstract

The research community responded rapidly to the SARS-CoV-2 pandemic with a burst of proteomic studies to understand this new virus. We focus in this chapter on proteomic approaches and advances in the areas of the viral proteome and the viral-host protein-protein interactions exploited to facilitate the pathogenic life cycle of SARS-CoV2. We also outline the proteome and posttranslational protein modifications of infected cells and blood proteomics of COVID-19 patients in relation to pathogenesis, host response, and disease severity. Finally, tools and application for COVID-19 proteomics and implementations in diagnostics and therapies are surveyed before summarizing the present achievements and future perspectives.

Original language	English
Title of host publication	Omics Approaches and Technologies in COVID-19
Publisher	Elsevier
Pages	61-85
Number of pages	25
ISBN (Electronic)	9780323917940
ISBN (Print)	9780323986212
DOIs	https://doi.org/10.1016/B978-0-323-91794-0.00002-0
Publication status	Published - 1 Jan 2022

Keywords

COVID-19
Posttranslational modifications (PTMs)
Protein-protein interactions (PPIs)
Proteome
Proteomic
SARS-CoV-2

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10.1016/B978-0-323-91794-0.00002-0

Cite this

Al-Ejeh, F., Merhi, M., Al-Muftah, M., Fernandes, Q., Al-Zaidan, L., Bedhiafi, T., Mestiri, S., Moustafa, D., Taib, N., Inchakalody, V., Raza, A., Uddin, S., & Dermime, S. (2022). Proteomic understanding of SARS-CoV-2 infection and COVID-19: Biological, diagnostic, and therapeutic perspectives. In Omics Approaches and Technologies in COVID-19 (pp. 61-85). Elsevier. https://doi.org/10.1016/B978-0-323-91794-0.00002-0

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Al-Ejeh, F, Merhi, M, Al-Muftah, M, Fernandes, Q, Al-Zaidan, L, Bedhiafi, T, Mestiri, S, Moustafa, D, Taib, N, Inchakalody, V, Raza, A, Uddin, S & Dermime, S 2022, Proteomic understanding of SARS-CoV-2 infection and COVID-19: Biological, diagnostic, and therapeutic perspectives. in Omics Approaches and Technologies in COVID-19. Elsevier, pp. 61-85. https://doi.org/10.1016/B978-0-323-91794-0.00002-0

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T1 - Proteomic understanding of SARS-CoV-2 infection and COVID-19

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AU - Al-Ejeh, Fares

AU - Merhi, Maysaloun

AU - Al-Muftah, Mariam

AU - Fernandes, Queenie

AU - Al-Zaidan, Lobna

AU - Bedhiafi, Takwa

AU - Mestiri, Sarra

AU - Moustafa, Dina

AU - Taib, Nassiba

AU - Inchakalody, Varghese

AU - Raza, Afsheen

AU - Uddin, Shahab

AU - Dermime, Said

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AB - The research community responded rapidly to the SARS-CoV-2 pandemic with a burst of proteomic studies to understand this new virus. We focus in this chapter on proteomic approaches and advances in the areas of the viral proteome and the viral-host protein-protein interactions exploited to facilitate the pathogenic life cycle of SARS-CoV2. We also outline the proteome and posttranslational protein modifications of infected cells and blood proteomics of COVID-19 patients in relation to pathogenesis, host response, and disease severity. Finally, tools and application for COVID-19 proteomics and implementations in diagnostics and therapies are surveyed before summarizing the present achievements and future perspectives.

KW - COVID-19

KW - Posttranslational modifications (PTMs)

KW - Protein-protein interactions (PPIs)

KW - Proteome

KW - Proteomic

KW - SARS-CoV-2

UR - https://www.scopus.com/pages/publications/85151720167

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DO - 10.1016/B978-0-323-91794-0.00002-0

M3 - Chapter

AN - SCOPUS:85151720167

SN - 9780323986212

SP - 61

EP - 85

BT - Omics Approaches and Technologies in COVID-19

PB - Elsevier

ER -

Proteomic understanding of SARS-CoV-2 infection and COVID-19: Biological, diagnostic, and therapeutic perspectives

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Keywords

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