Polygenic risk scores for schizophrenia and bipolar disorder predict creativity

Robert A. Power; Stacy Steinberg; Gyda Bjornsdottir; Cornelius A. Rietveld; Abdel Abdellaoui; Michel M. Nivard; Magnus Johannesson; Tessel E. Galesloot; Jouke J. Hottenga; Gonneke Willemsen; David Cesarini; Daniel J. Benjamin; Patrik K.E. Magnusson; Fredrik Ullén; Henning Tiemeier; Albert Hofman; Frank J.A. Van Rooij; G. Bragi Walters; Engilbert Sigurdsson; Thorgeir E. Thorgeirsson; Andres Ingason; Agnar Helgason; Augustine Kong; Lambertus A. Kiemeney; Philipp Koellinger; Dorret I. Boomsma; Daniel Gudbjartsson; Hreinn Stefansson; Kari Stefansson

doi:10.1038/nn.4040

Polygenic risk scores for schizophrenia and bipolar disorder predict creativity

Robert A. Power
, Stacy Steinberg
, Gyda Bjornsdottir
, Cornelius A. Rietveld
, Abdel Abdellaoui
, Michel M. Nivard
, Magnus Johannesson
, Tessel E. Galesloot
, Jouke J. Hottenga
, Gonneke Willemsen
, David Cesarini
, Daniel J. Benjamin
, Patrik K.E. Magnusson
, Fredrik Ullén
, Henning Tiemeier
, Albert Hofman
, Frank J.A. Van Rooij
, G. Bragi Walters
, Engilbert Sigurdsson
, Thorgeir E. Thorgeirsson

Andres Ingason, Agnar Helgason, Augustine Kong, Lambertus A. Kiemeney, Philipp Koellinger, Dorret I. Boomsma, Daniel Gudbjartsson, Hreinn Stefansson, Kari Stefansson^*

^*Corresponding author for this work

deCODE Genetics
Medical Research Council
Erasmus University Rotterdam
Vrije Universiteit Amsterdam
Stockholm School of Economics
Radboud University Nijmegen
New York University
University of Southern California
Karolinska Institutet
Landspitali University Hospital
University of Iceland
University of Amsterdam

Research output: Contribution to journal › Article › peer-review

Abstract

We tested whether polygenic risk scores for schizophrenia and bipolar disorder would predict creativity. Higher scores were associated with artistic society membership or creative profession in both Icelandic (P = 5.2 × 10 â '6 and 3.8 × 10 â '6 for schizophrenia and bipolar disorder scores, respectively) and replication cohorts (P = 0.0021 and 0.00086). This could not be accounted for by increased relatedness between creative individuals and those with psychoses, indicating that creativity and psychosis share genetic roots.

Original language	English
Pages (from-to)	953-955
Number of pages	3
Journal	Nature Neuroscience
Volume	18
Issue number	7
DOIs	https://doi.org/10.1038/nn.4040
Publication status	Published - 25 Jun 2015
Externally published	Yes

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10.1038/nn.4040

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Power, R. A., Steinberg, S., Bjornsdottir, G., Rietveld, C. A., Abdellaoui, A., Nivard, M. M., Johannesson, M., Galesloot, T. E., Hottenga, J. J., Willemsen, G., Cesarini, D., Benjamin, D. J., Magnusson, P. K. E., Ullén, F., Tiemeier, H., Hofman, A., Van Rooij, F. J. A., Walters, G. B., Sigurdsson, E., ... Stefansson, K. (2015). Polygenic risk scores for schizophrenia and bipolar disorder predict creativity. Nature Neuroscience, 18(7), 953-955. https://doi.org/10.1038/nn.4040

@article{8c3bc3a55db345758420b142994df662,

title = "Polygenic risk scores for schizophrenia and bipolar disorder predict creativity",

abstract = "We tested whether polygenic risk scores for schizophrenia and bipolar disorder would predict creativity. Higher scores were associated with artistic society membership or creative profession in both Icelandic (P = 5.2 × 10 {\^a} '6 and 3.8 × 10 {\^a} '6 for schizophrenia and bipolar disorder scores, respectively) and replication cohorts (P = 0.0021 and 0.00086). This could not be accounted for by increased relatedness between creative individuals and those with psychoses, indicating that creativity and psychosis share genetic roots.",

author = "Power, \{Robert A.\} and Stacy Steinberg and Gyda Bjornsdottir and Rietveld, \{Cornelius A.\} and Abdel Abdellaoui and Nivard, \{Michel M.\} and Magnus Johannesson and Galesloot, \{Tessel E.\} and Hottenga, \{Jouke J.\} and Gonneke Willemsen and David Cesarini and Benjamin, \{Daniel J.\} and Magnusson, \{Patrik K.E.\} and Fredrik Ull{\'e}n and Henning Tiemeier and Albert Hofman and \{Van Rooij\}, \{Frank J.A.\} and Walters, \{G. Bragi\} and Engilbert Sigurdsson and Thorgeirsson, \{Thorgeir E.\} and Andres Ingason and Agnar Helgason and Augustine Kong and Kiemeney, \{Lambertus A.\} and Philipp Koellinger and Boomsma, \{Dorret I.\} and Daniel Gudbjartsson and Hreinn Stefansson and Kari Stefansson",

note = "Publisher Copyright: {\textcopyright} 2015 Nature America, Inc.",

year = "2015",

month = jun,

day = "25",

doi = "10.1038/nn.4040",

language = "English",

volume = "18",

pages = "953--955",

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Power, RA, Steinberg, S, Bjornsdottir, G, Rietveld, CA, Abdellaoui, A, Nivard, MM, Johannesson, M, Galesloot, TE, Hottenga, JJ, Willemsen, G, Cesarini, D, Benjamin, DJ, Magnusson, PKE, Ullén, F, Tiemeier, H, Hofman, A, Van Rooij, FJA, Walters, GB, Sigurdsson, E, Thorgeirsson, TE, Ingason, A, Helgason, A, Kong, A, Kiemeney, LA, Koellinger, P, Boomsma, DI, Gudbjartsson, D, Stefansson, H & Stefansson, K 2015, 'Polygenic risk scores for schizophrenia and bipolar disorder predict creativity', Nature Neuroscience, vol. 18, no. 7, pp. 953-955. https://doi.org/10.1038/nn.4040

TY - JOUR

T1 - Polygenic risk scores for schizophrenia and bipolar disorder predict creativity

AU - Power, Robert A.

AU - Steinberg, Stacy

AU - Bjornsdottir, Gyda

AU - Rietveld, Cornelius A.

AU - Abdellaoui, Abdel

AU - Nivard, Michel M.

AU - Johannesson, Magnus

AU - Galesloot, Tessel E.

AU - Hottenga, Jouke J.

AU - Willemsen, Gonneke

AU - Cesarini, David

AU - Benjamin, Daniel J.

AU - Magnusson, Patrik K.E.

AU - Ullén, Fredrik

AU - Tiemeier, Henning

AU - Hofman, Albert

AU - Van Rooij, Frank J.A.

AU - Walters, G. Bragi

AU - Sigurdsson, Engilbert

AU - Thorgeirsson, Thorgeir E.

AU - Ingason, Andres

AU - Helgason, Agnar

AU - Kong, Augustine

AU - Kiemeney, Lambertus A.

AU - Koellinger, Philipp

AU - Boomsma, Dorret I.

AU - Gudbjartsson, Daniel

AU - Stefansson, Hreinn

AU - Stefansson, Kari

PY - 2015/6/25

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AB - We tested whether polygenic risk scores for schizophrenia and bipolar disorder would predict creativity. Higher scores were associated with artistic society membership or creative profession in both Icelandic (P = 5.2 × 10 â '6 and 3.8 × 10 â '6 for schizophrenia and bipolar disorder scores, respectively) and replication cohorts (P = 0.0021 and 0.00086). This could not be accounted for by increased relatedness between creative individuals and those with psychoses, indicating that creativity and psychosis share genetic roots.

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VL - 18

SP - 953

EP - 955

JO - Nature Neuroscience

JF - Nature Neuroscience

IS - 7

ER -

Polygenic risk scores for schizophrenia and bipolar disorder predict creativity

Abstract

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