Polygenic risk score assessment of LDL-Cholesterol levels and progression to severe hypercholesterolemia and statin treatment; a longitudinal study from a large middle eastern biobank

Umm Kulthum Ismail Umlai; Salman M. Toor; Usama Aliyu; Shaban Mohammed; Nadeem Qureshi; Moza S.H. Al Hail; Mohammed Gomaa; Amin Jayyousi; Jassim M. Al Suwaidi; Omar M.E. Albagha

doi:10.1016/j.ajpc.2026.101768

Polygenic risk score assessment of LDL-Cholesterol levels and progression to severe hypercholesterolemia and statin treatment; a longitudinal study from a large middle eastern biobank

Umm Kulthum Ismail Umlai
, Salman M. Toor
, Usama Aliyu
, Shaban Mohammed
, Nadeem Qureshi
, Moza S.H. Al Hail
, Mohammed Gomaa
, Amin Jayyousi
, Jassim M. Al Suwaidi
, Omar M.E. Albagha^*

^*Corresponding author for this work

Hamad Medical Corporation
University of Nottingham

Research output: Contribution to journal › Article › peer-review

Original language	English
Article number	101768
Journal	American Journal of Preventive Cardiology
DOIs	https://doi.org/10.1016/j.ajpc.2026.101768
Publication status	Accepted/In press - 2026

Keywords

Cholesterol
GWAS
Hypercholesterolemia
LDL-C
PGS
Polygenic risk score

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10.1016/j.ajpc.2026.101768

Cite this

Umlai, U. K. I., Toor, S. M., Aliyu, U., Mohammed, S., Qureshi, N., Al Hail, M. S. H., Gomaa, M., Jayyousi, A., Al Suwaidi, J. M., & Albagha, O. M. E. (Accepted/In press). Polygenic risk score assessment of LDL-Cholesterol levels and progression to severe hypercholesterolemia and statin treatment; a longitudinal study from a large middle eastern biobank. American Journal of Preventive Cardiology, Article 101768. https://doi.org/10.1016/j.ajpc.2026.101768

@article{b55f32fd8c2049d7b55293997eac209a,

title = "Polygenic risk score assessment of LDL-Cholesterol levels and progression to severe hypercholesterolemia and statin treatment; a longitudinal study from a large middle eastern biobank",

keywords = "Cholesterol, GWAS, Hypercholesterolemia, LDL-C, PGS, Polygenic risk score",

author = "Umlai, \{Umm Kulthum Ismail\} and Toor, \{Salman M.\} and Usama Aliyu and Shaban Mohammed and Nadeem Qureshi and \{Al Hail\}, \{Moza S.H.\} and Mohammed Gomaa and Amin Jayyousi and \{Al Suwaidi\}, \{Jassim M.\} and Albagha, \{Omar M.E.\}",

year = "2026",

doi = "10.1016/j.ajpc.2026.101768",

language = "English",

journal = "American Journal of Preventive Cardiology",

issn = "2666-6677",

publisher = "Elsevier B.V.",

}

Umlai, UKI , Toor, SM, Aliyu, U, Mohammed, S, Qureshi, N, Al Hail, MSH, Gomaa, M, Jayyousi, A, Al Suwaidi, JM & Albagha, OME 2026, 'Polygenic risk score assessment of LDL-Cholesterol levels and progression to severe hypercholesterolemia and statin treatment; a longitudinal study from a large middle eastern biobank', American Journal of Preventive Cardiology. https://doi.org/10.1016/j.ajpc.2026.101768

Polygenic risk score assessment of LDL-Cholesterol levels and progression to severe hypercholesterolemia and statin treatment; a longitudinal study from a large middle eastern biobank. / Umlai, Umm Kulthum Ismail ; Toor, Salman M.; Aliyu, Usama et al.
In: American Journal of Preventive Cardiology, 2026.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Polygenic risk score assessment of LDL-Cholesterol levels and progression to severe hypercholesterolemia and statin treatment; a longitudinal study from a large middle eastern biobank

AU - Umlai, Umm Kulthum Ismail

AU - Toor, Salman M.

AU - Aliyu, Usama

AU - Mohammed, Shaban

AU - Qureshi, Nadeem

AU - Al Hail, Moza S.H.

AU - Gomaa, Mohammed

AU - Jayyousi, Amin

AU - Al Suwaidi, Jassim M.

AU - Albagha, Omar M.E.

PY - 2026

Y1 - 2026

KW - Cholesterol

KW - GWAS

KW - Hypercholesterolemia

KW - LDL-C

KW - PGS

KW - Polygenic risk score

UR - https://www.scopus.com/pages/publications/105046108419

U2 - 10.1016/j.ajpc.2026.101768

DO - 10.1016/j.ajpc.2026.101768

M3 - Article

AN - SCOPUS:105046108419

SN - 2666-6677

JO - American Journal of Preventive Cardiology

JF - American Journal of Preventive Cardiology

M1 - 101768

ER -

Polygenic risk score assessment of LDL-Cholesterol levels and progression to severe hypercholesterolemia and statin treatment; a longitudinal study from a large middle eastern biobank

Keywords

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