Pharmacokinetics and pharmacodynamics of Levofloxacin against Streptococcus pneumoniae and Staphylococcus aureus in human skin blister fluid

Andrej Trampuz; Markus Wenk; Zarko Rajacic; Werner Zimmerli

doi:10.1128/AAC.44.5.1352-1355.2000

Pharmacokinetics and pharmacodynamics of Levofloxacin against Streptococcus pneumoniae and Staphylococcus aureus in human skin blister fluid

Andrej Trampuz, Markus Wenk, Zarko Rajacic, Werner Zimmerli^*

^*Corresponding author for this work

University of Basel

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

The pharmacokinetics of levofloxacin in serum and in skin blister fluid (SBF) was determined for 20 volunteers after a single 500-mg oral dose of levofloxacin. In addition, ex vivo bactericidal activity of SBF against Streptococcus pneumoniae and Staphylococcus aureus was studied. SBF containing levofloxacin and granulocytes killed 5.2 log of Streptococcus pneumoniae bacteria and 2.0 log of Staphylococcus aureus bacteria during a 6- h incubation.

Original language	English
Pages (from-to)	1352-1355
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	44
Issue number	5
DOIs	https://doi.org/10.1128/AAC.44.5.1352-1355.2000
Publication status	Published - May 2000
Externally published	Yes

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abstract = "The pharmacokinetics of levofloxacin in serum and in skin blister fluid (SBF) was determined for 20 volunteers after a single 500-mg oral dose of levofloxacin. In addition, ex vivo bactericidal activity of SBF against Streptococcus pneumoniae and Staphylococcus aureus was studied. SBF containing levofloxacin and granulocytes killed 5.2 log of Streptococcus pneumoniae bacteria and 2.0 log of Staphylococcus aureus bacteria during a 6- h incubation.",

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AU - Trampuz, Andrej

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AU - Rajacic, Zarko

AU - Zimmerli, Werner

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N2 - The pharmacokinetics of levofloxacin in serum and in skin blister fluid (SBF) was determined for 20 volunteers after a single 500-mg oral dose of levofloxacin. In addition, ex vivo bactericidal activity of SBF against Streptococcus pneumoniae and Staphylococcus aureus was studied. SBF containing levofloxacin and granulocytes killed 5.2 log of Streptococcus pneumoniae bacteria and 2.0 log of Staphylococcus aureus bacteria during a 6- h incubation.

AB - The pharmacokinetics of levofloxacin in serum and in skin blister fluid (SBF) was determined for 20 volunteers after a single 500-mg oral dose of levofloxacin. In addition, ex vivo bactericidal activity of SBF against Streptococcus pneumoniae and Staphylococcus aureus was studied. SBF containing levofloxacin and granulocytes killed 5.2 log of Streptococcus pneumoniae bacteria and 2.0 log of Staphylococcus aureus bacteria during a 6- h incubation.

UR - https://www.scopus.com/pages/publications/0034007920

U2 - 10.1128/AAC.44.5.1352-1355.2000

DO - 10.1128/AAC.44.5.1352-1355.2000

M3 - Article

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AN - SCOPUS:0034007920

SN - 0066-4804

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JO - Antimicrobial Agents and Chemotherapy

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ER -

Pharmacokinetics and pharmacodynamics of Levofloxacin against Streptococcus pneumoniae and Staphylococcus aureus in human skin blister fluid

Abstract

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