Pharmacokinetics and pharmaco dynamics of gatifloxacin against Streptococcus pneumoniae and Staphylococcus aureus in a granulocyte-rich exudate

Andrej Trampuz; Gerd Laifer; Markus Wenk; Zarko Rajacic; Werner Zimmerli

doi:10.1128/AAC.46.11.3630-3633.2002

Pharmacokinetics and pharmaco dynamics of gatifloxacin against Streptococcus pneumoniae and Staphylococcus aureus in a granulocyte-rich exudate

Andrej Trampuz
, Gerd Laifer
, Markus Wenk
, Zarko Rajacic
, Werner Zimmerli^*

^*Corresponding author for this work

University Medical Clinic

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

The pharmacokinetics of gatifloxacin were assessed in serum and in skin blister fluid (SBF), as was the pharmacodynamic activity in SBF. Five hours after a single dose of gatifloxacin, SBF killed 2.5 logs of Streptococcus pneumoniae and 1.5 log of Staphylococcus aureus during a 2-h incubation ex vivo.

Original language	English
Pages (from-to)	3630-3633
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	46
Issue number	11
DOIs	https://doi.org/10.1128/AAC.46.11.3630-3633.2002
Publication status	Published - Nov 2002
Externally published	Yes

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10.1128/AAC.46.11.3630-3633.2002

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title = "Pharmacokinetics and pharmaco dynamics of gatifloxacin against Streptococcus pneumoniae and Staphylococcus aureus in a granulocyte-rich exudate",

abstract = "The pharmacokinetics of gatifloxacin were assessed in serum and in skin blister fluid (SBF), as was the pharmacodynamic activity in SBF. Five hours after a single dose of gatifloxacin, SBF killed 2.5 logs of Streptococcus pneumoniae and 1.5 log of Staphylococcus aureus during a 2-h incubation ex vivo.",

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AU - Trampuz, Andrej

AU - Laifer, Gerd

AU - Wenk, Markus

AU - Rajacic, Zarko

AU - Zimmerli, Werner

PY - 2002/11

Y1 - 2002/11

N2 - The pharmacokinetics of gatifloxacin were assessed in serum and in skin blister fluid (SBF), as was the pharmacodynamic activity in SBF. Five hours after a single dose of gatifloxacin, SBF killed 2.5 logs of Streptococcus pneumoniae and 1.5 log of Staphylococcus aureus during a 2-h incubation ex vivo.

AB - The pharmacokinetics of gatifloxacin were assessed in serum and in skin blister fluid (SBF), as was the pharmacodynamic activity in SBF. Five hours after a single dose of gatifloxacin, SBF killed 2.5 logs of Streptococcus pneumoniae and 1.5 log of Staphylococcus aureus during a 2-h incubation ex vivo.

UR - https://www.scopus.com/pages/publications/0036827127

U2 - 10.1128/AAC.46.11.3630-3633.2002

DO - 10.1128/AAC.46.11.3630-3633.2002

M3 - Article

C2 - 12384378

AN - SCOPUS:0036827127

SN - 0066-4804

VL - 46

SP - 3630

EP - 3633

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 11

ER -

Pharmacokinetics and pharmaco dynamics of gatifloxacin against Streptococcus pneumoniae and Staphylococcus aureus in a granulocyte-rich exudate

Abstract

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