Nucleobase peptide amphiphiles

Christopher J. Serpell; Maciej Barłóg; Kaustuv Basu; Johans F. Fakhoury; Hassan S. Bazzi; Hanadi F. Sleiman

doi:10.1039/c3mh00154g

Nucleobase peptide amphiphiles

Christopher J. Serpell
, Maciej Barłóg
, Kaustuv Basu
, Johans F. Fakhoury
, Hassan S. Bazzi
, Hanadi F. Sleiman^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

A new class of peptide materials is introduced, integrating orthogonal aspects of peptide, nucleoside, and amphiphile chemistry. In solution, species such as rod-like or helical micelles are formed, which can lead to nanoribbons under lateral or longitudinal hierarchical growth regimes. Gelation of a wide range of solvents can be induced, including water and aqueous buffer, providing new avenues for nucleobase-specific electrophoresis, oligonucleotide delivery and bioactive cell growth media.

Original language	English
Pages (from-to)	348-354
Number of pages	7
Journal	Materials Horizons
Volume	1
Issue number	3
DOIs	https://doi.org/10.1039/c3mh00154g
Publication status	Published - May 2014
Externally published	Yes

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title = "Nucleobase peptide amphiphiles",

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AU - Basu, Kaustuv

AU - Fakhoury, Johans F.

AU - Bazzi, Hassan S.

AU - Sleiman, Hanadi F.

PY - 2014/5

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N2 - A new class of peptide materials is introduced, integrating orthogonal aspects of peptide, nucleoside, and amphiphile chemistry. In solution, species such as rod-like or helical micelles are formed, which can lead to nanoribbons under lateral or longitudinal hierarchical growth regimes. Gelation of a wide range of solvents can be induced, including water and aqueous buffer, providing new avenues for nucleobase-specific electrophoresis, oligonucleotide delivery and bioactive cell growth media.

AB - A new class of peptide materials is introduced, integrating orthogonal aspects of peptide, nucleoside, and amphiphile chemistry. In solution, species such as rod-like or helical micelles are formed, which can lead to nanoribbons under lateral or longitudinal hierarchical growth regimes. Gelation of a wide range of solvents can be induced, including water and aqueous buffer, providing new avenues for nucleobase-specific electrophoresis, oligonucleotide delivery and bioactive cell growth media.

UR - https://www.scopus.com/pages/publications/84949792974

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DO - 10.1039/c3mh00154g

M3 - Article

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Nucleobase peptide amphiphiles

Abstract

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