Novel chiral pyrrolidinone scaffolds derived from threonine with antibacterial activity

Muhammad Anwar; Andrew R. Cowley; Mark G. Moloney

doi:10.1016/j.tetasy.2010.04.064

Novel chiral pyrrolidinone scaffolds derived from threonine with antibacterial activity

Muhammad Anwar, Andrew R. Cowley, Mark G. Moloney

University of Oxford

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

The synthesis of chiral pyrrolidinones derived from threonine, making use of a Dieckmann or aldol ring closure, is described. Compounds were found to exhibit antibacterial activity, for which the correlation with various physiochemical parameters was examined. This chiral tetramate scaffold may provide a useful template for fragment-based drug design providing rapid access to novel antibacterial compound libraries.

Original language	English
Pages (from-to)	1758-1770
Number of pages	13
Journal	Tetrahedron Asymmetry
Volume	21
Issue number	13-14
DOIs	https://doi.org/10.1016/j.tetasy.2010.04.064
Publication status	Published - 2010
Externally published	Yes

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10.1016/j.tetasy.2010.04.064

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title = "Novel chiral pyrrolidinone scaffolds derived from threonine with antibacterial activity",

abstract = "The synthesis of chiral pyrrolidinones derived from threonine, making use of a Dieckmann or aldol ring closure, is described. Compounds were found to exhibit antibacterial activity, for which the correlation with various physiochemical parameters was examined. This chiral tetramate scaffold may provide a useful template for fragment-based drug design providing rapid access to novel antibacterial compound libraries.",

author = "Muhammad Anwar and Cowley, \{Andrew R.\} and Moloney, \{Mark G.\}",

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doi = "10.1016/j.tetasy.2010.04.064",

language = "English",

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T1 - Novel chiral pyrrolidinone scaffolds derived from threonine with antibacterial activity

AU - Anwar, Muhammad

AU - Cowley, Andrew R.

AU - Moloney, Mark G.

PY - 2010

Y1 - 2010

N2 - The synthesis of chiral pyrrolidinones derived from threonine, making use of a Dieckmann or aldol ring closure, is described. Compounds were found to exhibit antibacterial activity, for which the correlation with various physiochemical parameters was examined. This chiral tetramate scaffold may provide a useful template for fragment-based drug design providing rapid access to novel antibacterial compound libraries.

AB - The synthesis of chiral pyrrolidinones derived from threonine, making use of a Dieckmann or aldol ring closure, is described. Compounds were found to exhibit antibacterial activity, for which the correlation with various physiochemical parameters was examined. This chiral tetramate scaffold may provide a useful template for fragment-based drug design providing rapid access to novel antibacterial compound libraries.

UR - https://www.scopus.com/pages/publications/77956265570

U2 - 10.1016/j.tetasy.2010.04.064

DO - 10.1016/j.tetasy.2010.04.064

M3 - Article

AN - SCOPUS:77956265570

SN - 0957-4166

VL - 21

SP - 1758

EP - 1770

JO - Tetrahedron Asymmetry

JF - Tetrahedron Asymmetry

IS - 13-14

ER -

Novel chiral pyrrolidinone scaffolds derived from threonine with antibacterial activity

Abstract

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