No evidence for the involvement of CAG/CTG repeats from within 18q21.33-q23 in bipolar disorder

Dirk Goossens; Sandra Villafuerte; Fadel Tissir; Sofie Van Gestel; Stephan Claes; Daniel Souery; Isabelle Massat; Dirk Van Den Bossche; Karel Van Zand; Julien Mendlewicz; Christine Van Broeckhoven; Jurgen Del-Favero

doi:10.1038/sj.ejhg.5200469

No evidence for the involvement of CAG/CTG repeats from within 18q21.33-q23 in bipolar disorder

Dirk Goossens
, Sandra Villafuerte
, Fadel Tissir
, Sofie Van Gestel
, Stephan Claes
, Daniel Souery
, Isabelle Massat
, Dirk Van Den Bossche
, Karel Van Zand
, Julien Mendlewicz
, Christine Van Broeckhoven
, Jurgen Del-Favero^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

We previously identified 18q21.33-q23 as a candidate region in one BP family and constructed a yeast artificial chromosome (YAC) contig map. Here, we mapped eight known CAG/CTG repeats relative to 18q21.33-q23. We also isolated four CAG/CTG repeats from within the region using CAG/CTG YAC fragmentation, one of which is located in the 5' untranslated region of the CAP2 gene coding for a brain-expressed serine proteinase inhibitor. The triplet repeats located in the 18q21.33-q23 BP candidate region showed no expanded alleles in the linked BP family nor in a BP case-control sample. Moreover, only the CAP2 triplet repeat was polymorphic but no genetic association with BP disorder was observed.

Original language	English
Pages (from-to)	385-388
Number of pages	4
Journal	European Journal of Human Genetics
Volume	8
Issue number	5
DOIs	https://doi.org/10.1038/sj.ejhg.5200469
Publication status	Published - May 2000
Externally published	Yes

Keywords

Bipolar disorder
CAG/CTG
Chromosome 18
Trinucleotide repeat
YAC fragmentation

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10.1038/sj.ejhg.5200469

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Goossens, D., Villafuerte, S., Tissir, F., Van Gestel, S., Claes, S., Souery, D., Massat, I., Van Den Bossche, D., Van Zand, K., Mendlewicz, J., Van Broeckhoven, C., & Del-Favero, J. (2000). No evidence for the involvement of CAG/CTG repeats from within 18q21.33-q23 in bipolar disorder. European Journal of Human Genetics, 8(5), 385-388. https://doi.org/10.1038/sj.ejhg.5200469

@article{2b292688a0dc48d5886c036054bdf5ef,

title = "No evidence for the involvement of CAG/CTG repeats from within 18q21.33-q23 in bipolar disorder",

abstract = "We previously identified 18q21.33-q23 as a candidate region in one BP family and constructed a yeast artificial chromosome (YAC) contig map. Here, we mapped eight known CAG/CTG repeats relative to 18q21.33-q23. We also isolated four CAG/CTG repeats from within the region using CAG/CTG YAC fragmentation, one of which is located in the 5' untranslated region of the CAP2 gene coding for a brain-expressed serine proteinase inhibitor. The triplet repeats located in the 18q21.33-q23 BP candidate region showed no expanded alleles in the linked BP family nor in a BP case-control sample. Moreover, only the CAP2 triplet repeat was polymorphic but no genetic association with BP disorder was observed.",

keywords = "Bipolar disorder, CAG/CTG, Chromosome 18, Trinucleotide repeat, YAC fragmentation",

author = "Dirk Goossens and Sandra Villafuerte and Fadel Tissir and \{Van Gestel\}, Sofie and Stephan Claes and Daniel Souery and Isabelle Massat and \{Van Den Bossche\}, Dirk and \{Van Zand\}, Karel and Julien Mendlewicz and \{Van Broeckhoven\}, Christine and Jurgen Del-Favero",

year = "2000",

month = may,

doi = "10.1038/sj.ejhg.5200469",

language = "English",

volume = "8",

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journal = "European Journal of Human Genetics",

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Goossens, D, Villafuerte, S, Tissir, F, Van Gestel, S, Claes, S, Souery, D, Massat, I, Van Den Bossche, D, Van Zand, K, Mendlewicz, J, Van Broeckhoven, C & Del-Favero, J 2000, 'No evidence for the involvement of CAG/CTG repeats from within 18q21.33-q23 in bipolar disorder', European Journal of Human Genetics, vol. 8, no. 5, pp. 385-388. https://doi.org/10.1038/sj.ejhg.5200469

TY - JOUR

T1 - No evidence for the involvement of CAG/CTG repeats from within 18q21.33-q23 in bipolar disorder

AU - Goossens, Dirk

AU - Villafuerte, Sandra

AU - Tissir, Fadel

AU - Van Gestel, Sofie

AU - Claes, Stephan

AU - Souery, Daniel

AU - Massat, Isabelle

AU - Van Den Bossche, Dirk

AU - Van Zand, Karel

AU - Mendlewicz, Julien

AU - Van Broeckhoven, Christine

AU - Del-Favero, Jurgen

PY - 2000/5

Y1 - 2000/5

N2 - We previously identified 18q21.33-q23 as a candidate region in one BP family and constructed a yeast artificial chromosome (YAC) contig map. Here, we mapped eight known CAG/CTG repeats relative to 18q21.33-q23. We also isolated four CAG/CTG repeats from within the region using CAG/CTG YAC fragmentation, one of which is located in the 5' untranslated region of the CAP2 gene coding for a brain-expressed serine proteinase inhibitor. The triplet repeats located in the 18q21.33-q23 BP candidate region showed no expanded alleles in the linked BP family nor in a BP case-control sample. Moreover, only the CAP2 triplet repeat was polymorphic but no genetic association with BP disorder was observed.

AB - We previously identified 18q21.33-q23 as a candidate region in one BP family and constructed a yeast artificial chromosome (YAC) contig map. Here, we mapped eight known CAG/CTG repeats relative to 18q21.33-q23. We also isolated four CAG/CTG repeats from within the region using CAG/CTG YAC fragmentation, one of which is located in the 5' untranslated region of the CAP2 gene coding for a brain-expressed serine proteinase inhibitor. The triplet repeats located in the 18q21.33-q23 BP candidate region showed no expanded alleles in the linked BP family nor in a BP case-control sample. Moreover, only the CAP2 triplet repeat was polymorphic but no genetic association with BP disorder was observed.

KW - Bipolar disorder

KW - CAG/CTG

KW - Chromosome 18

KW - Trinucleotide repeat

KW - YAC fragmentation

UR - https://www.scopus.com/pages/publications/0034037538

U2 - 10.1038/sj.ejhg.5200469

DO - 10.1038/sj.ejhg.5200469

M3 - Article

C2 - 10854100

AN - SCOPUS:0034037538

SN - 1018-4813

VL - 8

SP - 385

EP - 388

JO - European Journal of Human Genetics

JF - European Journal of Human Genetics

IS - 5

ER -

No evidence for the involvement of CAG/CTG repeats from within 18q21.33-q23 in bipolar disorder

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