New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism

Momoko Horikoshi; Hanieh Yaghootkar; Dennis O. Mook-Kanamori; Ulla Sovio; H. Rob Taal; Branwen J. Hennig; Jonathan P. Bradfield; Beate St Pourcain; David M. Evans; Pimphen Charoen; Marika Kaakinen; Diana L. Cousminer; Terho Lehtimäki; Eskil Kreiner-Møller; Nicole M. Warrington; Mariona Bustamante; Bjarke Feenstra; Diane J. Berry; Elisabeth Thiering; Thiemo Pfab; Sheila J. Barton; Beverley M. Shields; Marjan Kerkhof; Elisabeth M. Van Leeuwen; Anthony J. Fulford; Zoltán Kutalik; Jing Hua Zhao; Marcel Den Hoed; Anubha Mahajan; Virpi Lindi; Liang Kee Goh; Jouke Jan Hottenga; Ying Wu; Olli T. Raitakari; Marie N. Harder; Aline Meirhaeghe; Ioanna Ntalla; Rany M. Salem; Karen A. Jameson; Kaixin Zhou; Dorota M. Monies; Vasiliki Lagou; Mirna Kirin; Jani Heikkinen; Linda S. Adair; Fowzan S. Alkuraya; Ali Al-Odaib; Philippe Amouyel; Ehm Astrid Andersson; Amanda J. Bennett; Alexandra I.F. Blakemore; Jessica L. Buxton; Jean Dallongeville; Shikta Das; Eco J.C. De Geus; Xavier Estivill; Claudia Flexeder; Philippe Froguel; Frank Geller; Keith M. Godfrey; Frédéric Gottrand; Christopher J. Groves; Torben Hansen; Joel N. Hirschhorn; Albert Hofman; Mads V. Hollegaard; David M. Hougaard; Elina Hyppönen; Hazel M. Inskip; Aaron Isaacs; Torben Jørgensen; Christina Kanaka-Gantenbein; John P. Kemp; Wieland Kiess; Tuomas O. Kilpeläinen; Norman Klopp; Bridget A. Knight; Christopher W. Kuzawa; George Mcmahon; John P. Newnham; Harri Niinikoski; Ben A. Oostra; Louise Pedersen; Dirkje S. Postma; Susan M. Ring; Fernando Rivadeneira; Neil R. Robertson; Sylvain Sebert; Olli Simell; Torsten Slowinski; Carla M.T. Tiesler; Anke Tönjes; Allan Vaag; Jorma S. Viikari; Jacqueline M. Vink; Nadja Hawwa Vissing; Nicholas J. Wareham; Gonneke Willemsen; Daniel R. Witte; Haitao Zhang; Jianhua Zhao; James F. Wilson; Michael Stumvoll; Andrew M. Prentice; Brian F. Meyer; Ewan R. Pearson; Colin A.G. Boreham; Cyrus Cooper; Matthew W. Gillman; George V. Dedoussis; Luis A. Moreno; Oluf Pedersen; Maiju Saarinen; Karen L. Mohlke; Dorret I. Boomsma; Seang Mei Saw; Timo A. Lakka; Antje Körner; Ruth J.F. Loos; Ken K. Ong; Peter Vollenweider; Cornelia M. Van Duijn; Gerard H. Koppelman; Andrew T. Hattersley; John W. Holloway; Berthold Hocher; Joachim Heinrich; Chris Power; Mads Melbye; Mònica Guxens; Craig E. Pennell; Klaus Bønnelykke; Hans Bisgaard; Johan G. Eriksson; Elisabeth Widén; Hakon Hakonarson; André G. Uitterlinden; Anneli Pouta; Debbie A. Lawlor; George Davey Smith; Timothy M. Frayling; Mark I. McCarthy; Struan F.A. Grant; Vincent W.V. Jaddoe; Marjo Riitta Jarvelin; Nicholas J. Timpson; Inga Prokopenko; Rachel M. Freathy

doi:10.1038/ng.2477

New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism

Momoko Horikoshi
, Hanieh Yaghootkar
, Dennis O. Mook-Kanamori
, Ulla Sovio
, H. Rob Taal
, Branwen J. Hennig
, Jonathan P. Bradfield
, Beate St Pourcain
, David M. Evans
, Pimphen Charoen
, Marika Kaakinen
, Diana L. Cousminer
, Terho Lehtimäki
, Eskil Kreiner-Møller
, Nicole M. Warrington
, Mariona Bustamante
, Bjarke Feenstra
, Diane J. Berry
, Elisabeth Thiering
, Thiemo Pfab

Sheila J. Barton, Beverley M. Shields, Marjan Kerkhof, Elisabeth M. Van Leeuwen, Anthony J. Fulford, Zoltán Kutalik, Jing Hua Zhao, Marcel Den Hoed, Anubha Mahajan, Virpi Lindi, Liang Kee Goh, Jouke Jan Hottenga, Ying Wu, Olli T. Raitakari, Marie N. Harder, Aline Meirhaeghe, Ioanna Ntalla, Rany M. Salem, Karen A. Jameson, Kaixin Zhou, Dorota M. Monies, Vasiliki Lagou, Mirna Kirin, Jani Heikkinen, Linda S. Adair, Fowzan S. Alkuraya, Ali Al-Odaib, Philippe Amouyel, Ehm Astrid Andersson, Amanda J. Bennett, Alexandra I.F. Blakemore, Jessica L. Buxton, Jean Dallongeville, Shikta Das, Eco J.C. De Geus, Xavier Estivill, Claudia Flexeder, Philippe Froguel, Frank Geller, Keith M. Godfrey, Frédéric Gottrand, Christopher J. Groves, Torben Hansen, Joel N. Hirschhorn, Albert Hofman, Mads V. Hollegaard, David M. Hougaard, Elina Hyppönen, Hazel M. Inskip, Aaron Isaacs, Torben Jørgensen, Christina Kanaka-Gantenbein, John P. Kemp, Wieland Kiess, Tuomas O. Kilpeläinen, Norman Klopp, Bridget A. Knight, Christopher W. Kuzawa, George Mcmahon, John P. Newnham, Harri Niinikoski, Ben A. Oostra, Louise Pedersen, Dirkje S. Postma, Susan M. Ring, Fernando Rivadeneira, Neil R. Robertson, Sylvain Sebert, Olli Simell, Torsten Slowinski, Carla M.T. Tiesler, Anke Tönjes, Allan Vaag, Jorma S. Viikari, Jacqueline M. Vink, Nadja Hawwa Vissing, Nicholas J. Wareham, Gonneke Willemsen, Daniel R. Witte, Haitao Zhang, Jianhua Zhao, James F. Wilson, Michael Stumvoll, Andrew M. Prentice, Brian F. Meyer, Ewan R. Pearson, Colin A.G. Boreham, Cyrus Cooper, Matthew W. Gillman, George V. Dedoussis, Luis A. Moreno, Oluf Pedersen, Maiju Saarinen, Karen L. Mohlke, Dorret I. Boomsma, Seang Mei Saw, Timo A. Lakka, Antje Körner, Ruth J.F. Loos, Ken K. Ong, Peter Vollenweider, Cornelia M. Van Duijn, Gerard H. Koppelman, Andrew T. Hattersley, John W. Holloway, Berthold Hocher, Joachim Heinrich, Chris Power, Mads Melbye, Mònica Guxens, Craig E. Pennell, Klaus Bønnelykke, Hans Bisgaard, Johan G. Eriksson, Elisabeth Widén, Hakon Hakonarson, André G. Uitterlinden, Anneli Pouta, Debbie A. Lawlor, George Davey Smith, Timothy M. Frayling, Mark I. McCarthy^*, Struan F.A. Grant, Vincent W.V. Jaddoe, Marjo Riitta Jarvelin, Nicholas J. Timpson, Inga Prokopenko, Rachel M. Freathy

^*Corresponding author for this work

University of Oxford
University of Exeter
Erasmus University Rotterdam
Weill Cornell Medicine-Qatar
Imperial College London
London School of Hygiene and Tropical Medicine
Medical Research Council
Medical Research Council Laboratories Gambia
Children's Hospital of Philadelphia
University of Bristol
Mahidol University
University of Oulu
University of Helsinki
Tampere University
University of Copenhagen
University of Western Australia
Barcelona Institute for Global Health
Hospital del Mar
Biomedical Research Networking Center in Epidemiology and Public Health (CiberESP)
Centre for Genomic Regulation
Statens Serum Institut
University College London
Helmholtz Zentrum München - German Research Center for Environmental Health
Charité – Universitätsmedizin Berlin
University of Potsdam
MRC Lifecourse Epidemiology Unit
Royal Devon & Exeter NHS Foundation Trust
University of Groningen
University of Lausanne
Swiss Institute of Bioinformatics
Cambridge University Hospitals NHS Foundation Trust
University of Eastern Finland
Duke-NUS Medical School
National University of Singapore
Vrije Universiteit Amsterdam
University of North Carolina at Chapel Hill
University of Turku
Institut national de la santé et de la recherche médicale
Institut Pasteur de Lille
Université de Lille
Harokopio University
Boston Children's Hospital
Broad Institute
Harvard University
University of Dundee
King Faisal Specialist Hospital and Research Centre
University of Edinburgh
King Khaled Eye Specialist Hospital
Alfaisal University
Pompeu Fabra University
Hammersmith Hospital
University Hospital Southampton NHS Foundation Trust
Université de Lille 2
University of Southern Denmark
Leiden University
National and Kapodistrian University of Athens
Leipzig University
Hannover Medical School
Northwestern University
Ludwig Maximilian University of Munich
Novo Nordisk Foundation
University College Dublin
University of Zaragoza
Aarhus University
Singapore National Eye Center
University of Southampton
German Centre for Cardiovascular Research
Helsinki University Hospital
Folkhalsan
Vaasa Hospital District
National Institute for Health and Welfare
University of Pennsylvania
Oxford University Hospitals NHS Foundation Trust
UK Health Security Agency

Research output: Contribution to journal › Article › peer-review

264 Citations (Scopus)

Abstract

Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood. Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits. In an expanded genome-wide association meta-analysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism.

Original language	English
Pages (from-to)	76-82
Number of pages	7
Journal	Nature Genetics
Volume	45
Issue number	1
DOIs	https://doi.org/10.1038/ng.2477
Publication status	Published - Jan 2013
Externally published	Yes

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Horikoshi, M., Yaghootkar, H., Mook-Kanamori, D. O., Sovio, U., Taal, H. R., Hennig, B. J., Bradfield, J. P., St Pourcain, B., Evans, D. M., Charoen, P., Kaakinen, M., Cousminer, D. L., Lehtimäki, T., Kreiner-Møller, E., Warrington, N. M., Bustamante, M., Feenstra, B., Berry, D. J., Thiering, E., ... Freathy, R. M. (2013). New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. Nature Genetics, 45(1), 76-82. https://doi.org/10.1038/ng.2477

@article{ab309643b1c84787a64d531ba264678b,

title = "New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism",

abstract = "Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood. Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits. In an expanded genome-wide association meta-analysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism.",

author = "Momoko Horikoshi and Hanieh Yaghootkar and Mook-Kanamori, \{Dennis O.\} and Ulla Sovio and Taal, \{H. Rob\} and Hennig, \{Branwen J.\} and Bradfield, \{Jonathan P.\} and \{St Pourcain\}, Beate and Evans, \{David M.\} and Pimphen Charoen and Marika Kaakinen and Cousminer, \{Diana L.\} and Terho Lehtim{\"a}ki and Eskil Kreiner-M{\o}ller and Warrington, \{Nicole M.\} and Mariona Bustamante and Bjarke Feenstra and Berry, \{Diane J.\} and Elisabeth Thiering and Thiemo Pfab and Barton, \{Sheila J.\} and Shields, \{Beverley M.\} and Marjan Kerkhof and \{Van Leeuwen\}, \{Elisabeth M.\} and Fulford, \{Anthony J.\} and Zolt{\'a}n Kutalik and Zhao, \{Jing Hua\} and \{Den Hoed\}, Marcel and Anubha Mahajan and Virpi Lindi and Goh, \{Liang Kee\} and Hottenga, \{Jouke Jan\} and Ying Wu and Raitakari, \{Olli T.\} and Harder, \{Marie N.\} and Aline Meirhaeghe and Ioanna Ntalla and Salem, \{Rany M.\} and Jameson, \{Karen A.\} and Kaixin Zhou and Monies, \{Dorota M.\} and Vasiliki Lagou and Mirna Kirin and Jani Heikkinen and Adair, \{Linda S.\} and Alkuraya, \{Fowzan S.\} and Ali Al-Odaib and Philippe Amouyel and Andersson, \{Ehm Astrid\} and Bennett, \{Amanda J.\} and Blakemore, \{Alexandra I.F.\} and Buxton, \{Jessica L.\} and Jean Dallongeville and Shikta Das and \{De Geus\}, \{Eco J.C.\} and Xavier Estivill and Claudia Flexeder and Philippe Froguel and Frank Geller and Godfrey, \{Keith M.\} and Fr{\'e}d{\'e}ric Gottrand and Groves, \{Christopher J.\} and Torben Hansen and Hirschhorn, \{Joel N.\} and Albert Hofman and Hollegaard, \{Mads V.\} and Hougaard, \{David M.\} and Elina Hypp{\"o}nen and Inskip, \{Hazel M.\} and Aaron Isaacs and Torben J{\o}rgensen and Christina Kanaka-Gantenbein and Kemp, \{John P.\} and Wieland Kiess and Kilpel{\"a}inen, \{Tuomas O.\} and Norman Klopp and Knight, \{Bridget A.\} and Kuzawa, \{Christopher W.\} and George Mcmahon and Newnham, \{John P.\} and Harri Niinikoski and Oostra, \{Ben A.\} and Louise Pedersen and Postma, \{Dirkje S.\} and Ring, \{Susan M.\} and Fernando Rivadeneira and Robertson, \{Neil R.\} and Sylvain Sebert and Olli Simell and Torsten Slowinski and Tiesler, \{Carla M.T.\} and Anke T{\"o}njes and Allan Vaag and Viikari, \{Jorma S.\} and Vink, \{Jacqueline M.\} and Vissing, \{Nadja Hawwa\} and Wareham, \{Nicholas J.\} and Gonneke Willemsen and Witte, \{Daniel R.\} and Haitao Zhang and Jianhua Zhao and Wilson, \{James F.\} and Michael Stumvoll and Prentice, \{Andrew M.\} and Meyer, \{Brian F.\} and Pearson, \{Ewan R.\} and Boreham, \{Colin A.G.\} and Cyrus Cooper and Gillman, \{Matthew W.\} and Dedoussis, \{George V.\} and Moreno, \{Luis A.\} and Oluf Pedersen and Maiju Saarinen and Mohlke, \{Karen L.\} and Boomsma, \{Dorret I.\} and Saw, \{Seang Mei\} and Lakka, \{Timo A.\} and Antje K{\"o}rner and Loos, \{Ruth J.F.\} and Ong, \{Ken K.\} and Peter Vollenweider and \{Van Duijn\}, \{Cornelia M.\} and Koppelman, \{Gerard H.\} and Hattersley, \{Andrew T.\} and Holloway, \{John W.\} and Berthold Hocher and Joachim Heinrich and Chris Power and Mads Melbye and M{\`o}nica Guxens and Pennell, \{Craig E.\} and Klaus B{\o}nnelykke and Hans Bisgaard and Eriksson, \{Johan G.\} and Elisabeth Wid{\'e}n and Hakon Hakonarson and Uitterlinden, \{Andr{\'e} G.\} and Anneli Pouta and Lawlor, \{Debbie A.\} and Smith, \{George Davey\} and Frayling, \{Timothy M.\} and McCarthy, \{Mark I.\} and Grant, \{Struan F.A.\} and Jaddoe, \{Vincent W.V.\} and Jarvelin, \{Marjo Riitta\} and Timpson, \{Nicholas J.\} and Inga Prokopenko and Freathy, \{Rachel M.\}",

year = "2013",

month = jan,

doi = "10.1038/ng.2477",

language = "English",

volume = "45",

pages = "76--82",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Research",

number = "1",

}

Horikoshi, M, Yaghootkar, H, Mook-Kanamori, DO, Sovio, U, Taal, HR, Hennig, BJ, Bradfield, JP, St Pourcain, B, Evans, DM, Charoen, P, Kaakinen, M, Cousminer, DL, Lehtimäki, T, Kreiner-Møller, E, Warrington, NM, Bustamante, M, Feenstra, B, Berry, DJ, Thiering, E, Pfab, T, Barton, SJ, Shields, BM, Kerkhof, M, Van Leeuwen, EM, Fulford, AJ, Kutalik, Z, Zhao, JH, Den Hoed, M, Mahajan, A, Lindi, V, Goh, LK, Hottenga, JJ, Wu, Y, Raitakari, OT, Harder, MN, Meirhaeghe, A, Ntalla, I, Salem, RM, Jameson, KA, Zhou, K, Monies, DM, Lagou, V, Kirin, M, Heikkinen, J, Adair, LS, Alkuraya, FS, Al-Odaib, A, Amouyel, P, Andersson, EA, Bennett, AJ, Blakemore, AIF, Buxton, JL, Dallongeville, J, Das, S, De Geus, EJC, Estivill, X, Flexeder, C, Froguel, P, Geller, F, Godfrey, KM, Gottrand, F, Groves, CJ, Hansen, T, Hirschhorn, JN, Hofman, A, Hollegaard, MV, Hougaard, DM, Hyppönen, E, Inskip, HM, Isaacs, A, Jørgensen, T, Kanaka-Gantenbein, C, Kemp, JP, Kiess, W, Kilpeläinen, TO, Klopp, N, Knight, BA, Kuzawa, CW, Mcmahon, G, Newnham, JP, Niinikoski, H, Oostra, BA, Pedersen, L, Postma, DS, Ring, SM, Rivadeneira, F, Robertson, NR, Sebert, S, Simell, O, Slowinski, T, Tiesler, CMT, Tönjes, A, Vaag, A, Viikari, JS, Vink, JM, Vissing, NH, Wareham, NJ, Willemsen, G, Witte, DR, Zhang, H, Zhao, J, Wilson, JF, Stumvoll, M, Prentice, AM, Meyer, BF, Pearson, ER, Boreham, CAG, Cooper, C, Gillman, MW, Dedoussis, GV, Moreno, LA, Pedersen, O, Saarinen, M, Mohlke, KL, Boomsma, DI, Saw, SM, Lakka, TA, Körner, A, Loos, RJF, Ong, KK, Vollenweider, P, Van Duijn, CM, Koppelman, GH, Hattersley, AT, Holloway, JW, Hocher, B, Heinrich, J, Power, C, Melbye, M, Guxens, M, Pennell, CE, Bønnelykke, K, Bisgaard, H, Eriksson, JG, Widén, E, Hakonarson, H, Uitterlinden, AG, Pouta, A, Lawlor, DA, Smith, GD, Frayling, TM, McCarthy, MI, Grant, SFA, Jaddoe, VWV, Jarvelin, MR, Timpson, NJ, Prokopenko, I & Freathy, RM 2013, 'New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism', Nature Genetics, vol. 45, no. 1, pp. 76-82. https://doi.org/10.1038/ng.2477

TY - JOUR

T1 - New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism

AU - Horikoshi, Momoko

AU - Yaghootkar, Hanieh

AU - Mook-Kanamori, Dennis O.

AU - Sovio, Ulla

AU - Taal, H. Rob

AU - Hennig, Branwen J.

AU - Bradfield, Jonathan P.

AU - St Pourcain, Beate

AU - Evans, David M.

AU - Charoen, Pimphen

AU - Kaakinen, Marika

AU - Cousminer, Diana L.

AU - Lehtimäki, Terho

AU - Kreiner-Møller, Eskil

AU - Warrington, Nicole M.

AU - Bustamante, Mariona

AU - Feenstra, Bjarke

AU - Berry, Diane J.

AU - Thiering, Elisabeth

AU - Pfab, Thiemo

AU - Barton, Sheila J.

AU - Shields, Beverley M.

AU - Kerkhof, Marjan

AU - Van Leeuwen, Elisabeth M.

AU - Fulford, Anthony J.

AU - Kutalik, Zoltán

AU - Zhao, Jing Hua

AU - Den Hoed, Marcel

AU - Mahajan, Anubha

AU - Lindi, Virpi

AU - Goh, Liang Kee

AU - Hottenga, Jouke Jan

AU - Wu, Ying

AU - Raitakari, Olli T.

AU - Harder, Marie N.

AU - Meirhaeghe, Aline

AU - Ntalla, Ioanna

AU - Salem, Rany M.

AU - Jameson, Karen A.

AU - Zhou, Kaixin

AU - Monies, Dorota M.

AU - Lagou, Vasiliki

AU - Kirin, Mirna

AU - Heikkinen, Jani

AU - Adair, Linda S.

AU - Alkuraya, Fowzan S.

AU - Al-Odaib, Ali

AU - Amouyel, Philippe

AU - Andersson, Ehm Astrid

AU - Bennett, Amanda J.

AU - Blakemore, Alexandra I.F.

AU - Buxton, Jessica L.

AU - Dallongeville, Jean

AU - Das, Shikta

AU - De Geus, Eco J.C.

AU - Estivill, Xavier

AU - Flexeder, Claudia

AU - Froguel, Philippe

AU - Geller, Frank

AU - Godfrey, Keith M.

AU - Gottrand, Frédéric

AU - Groves, Christopher J.

AU - Hansen, Torben

AU - Hirschhorn, Joel N.

AU - Hofman, Albert

AU - Hollegaard, Mads V.

AU - Hougaard, David M.

AU - Hyppönen, Elina

AU - Inskip, Hazel M.

AU - Isaacs, Aaron

AU - Jørgensen, Torben

AU - Kanaka-Gantenbein, Christina

AU - Kemp, John P.

AU - Kiess, Wieland

AU - Kilpeläinen, Tuomas O.

AU - Klopp, Norman

AU - Knight, Bridget A.

AU - Kuzawa, Christopher W.

AU - Mcmahon, George

AU - Newnham, John P.

AU - Niinikoski, Harri

AU - Oostra, Ben A.

AU - Pedersen, Louise

AU - Postma, Dirkje S.

AU - Ring, Susan M.

AU - Rivadeneira, Fernando

AU - Robertson, Neil R.

AU - Sebert, Sylvain

AU - Simell, Olli

AU - Slowinski, Torsten

AU - Tiesler, Carla M.T.

AU - Tönjes, Anke

AU - Vaag, Allan

AU - Viikari, Jorma S.

AU - Vink, Jacqueline M.

AU - Vissing, Nadja Hawwa

AU - Wareham, Nicholas J.

AU - Willemsen, Gonneke

AU - Witte, Daniel R.

AU - Zhang, Haitao

AU - Zhao, Jianhua

AU - Wilson, James F.

AU - Stumvoll, Michael

AU - Prentice, Andrew M.

AU - Meyer, Brian F.

AU - Pearson, Ewan R.

AU - Boreham, Colin A.G.

AU - Cooper, Cyrus

AU - Gillman, Matthew W.

AU - Dedoussis, George V.

AU - Moreno, Luis A.

AU - Pedersen, Oluf

AU - Saarinen, Maiju

AU - Mohlke, Karen L.

AU - Boomsma, Dorret I.

AU - Saw, Seang Mei

AU - Lakka, Timo A.

AU - Körner, Antje

AU - Loos, Ruth J.F.

AU - Ong, Ken K.

AU - Vollenweider, Peter

AU - Van Duijn, Cornelia M.

AU - Koppelman, Gerard H.

AU - Hattersley, Andrew T.

AU - Holloway, John W.

AU - Hocher, Berthold

AU - Heinrich, Joachim

AU - Power, Chris

AU - Melbye, Mads

AU - Guxens, Mònica

AU - Pennell, Craig E.

AU - Bønnelykke, Klaus

AU - Bisgaard, Hans

AU - Eriksson, Johan G.

AU - Widén, Elisabeth

AU - Hakonarson, Hakon

AU - Uitterlinden, André G.

AU - Pouta, Anneli

AU - Lawlor, Debbie A.

AU - Smith, George Davey

AU - Frayling, Timothy M.

AU - McCarthy, Mark I.

AU - Grant, Struan F.A.

AU - Jaddoe, Vincent W.V.

AU - Jarvelin, Marjo Riitta

AU - Timpson, Nicholas J.

AU - Prokopenko, Inga

AU - Freathy, Rachel M.

PY - 2013/1

Y1 - 2013/1

N2 - Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood. Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits. In an expanded genome-wide association meta-analysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism.

AB - Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood. Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits. In an expanded genome-wide association meta-analysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism.

UR - https://www.scopus.com/pages/publications/84871987100

U2 - 10.1038/ng.2477

DO - 10.1038/ng.2477

M3 - Article

C2 - 23202124

AN - SCOPUS:84871987100

SN - 1061-4036

VL - 45

SP - 76

EP - 82

JO - Nature Genetics

JF - Nature Genetics

IS - 1

ER -

New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism

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