Neuo: A fluorescent chemical probe for live neuron labeling

Jun Cheng Er; Cheryl Leong; Chai Lean Teoh; Qiang Yuan; Paolomi Merchant; Matthew Dunn; David Sulzer; Dalibor Sames; Akshay Bhinge; Dongyoon Kim; Seong Min Kim; Myung Han Yoon; Lawrence W. Stanton; Shawn H. Je; Seong Wook Yun; Young Tae Chang

doi:10.1002/anie.201408614

Neuo: A fluorescent chemical probe for live neuron labeling

Jun Cheng Er
, Cheryl Leong
, Chai Lean Teoh
, Qiang Yuan
, Paolomi Merchant
, Matthew Dunn
, David Sulzer
, Dalibor Sames
, Akshay Bhinge
, Dongyoon Kim
, Seong Min Kim
, Myung Han Yoon
, Lawrence W. Stanton
, Shawn H. Je
, Seong Wook Yun
, Young Tae Chang

Research output: Contribution to journal › Article › peer-review

76 Citations (Scopus)

Abstract

To address existing limitations in live neuron imaging, we have developed NeuO, a novel cell-permeable fluorescent probe with an unprecedented ability to label and image live neurons selectively over other cells in the brain. NeuO enables robust live neuron imaging and isolation in vivo and in vitro across species; its versatility and ease of use sets the basis for its development in a myriad of neuronal targeting applications.

Original language	English
Pages (from-to)	2442-2446
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	54
Issue number	8
DOIs	https://doi.org/10.1002/anie.201408614
Publication status	Published - 16 Feb 2015
Externally published	Yes

Keywords

BODIPY
Fluorescent probes
Imaging agents
Live neurons

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10.1002/anie.201408614

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title = "Neuo: A fluorescent chemical probe for live neuron labeling",

abstract = "To address existing limitations in live neuron imaging, we have developed NeuO, a novel cell-permeable fluorescent probe with an unprecedented ability to label and image live neurons selectively over other cells in the brain. NeuO enables robust live neuron imaging and isolation in vivo and in vitro across species; its versatility and ease of use sets the basis for its development in a myriad of neuronal targeting applications.",

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AU - Er, Jun Cheng

AU - Leong, Cheryl

AU - Teoh, Chai Lean

AU - Yuan, Qiang

AU - Merchant, Paolomi

AU - Dunn, Matthew

AU - Sulzer, David

AU - Sames, Dalibor

AU - Bhinge, Akshay

AU - Kim, Dongyoon

AU - Kim, Seong Min

AU - Yoon, Myung Han

AU - Stanton, Lawrence W.

AU - Je, Shawn H.

AU - Yun, Seong Wook

AU - Chang, Young Tae

PY - 2015/2/16

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AB - To address existing limitations in live neuron imaging, we have developed NeuO, a novel cell-permeable fluorescent probe with an unprecedented ability to label and image live neurons selectively over other cells in the brain. NeuO enables robust live neuron imaging and isolation in vivo and in vitro across species; its versatility and ease of use sets the basis for its development in a myriad of neuronal targeting applications.

KW - BODIPY

KW - Fluorescent probes

KW - Imaging agents

KW - Live neurons

UR - https://www.scopus.com/pages/publications/84922758181

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JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 8

ER -

Neuo: A fluorescent chemical probe for live neuron labeling

Abstract

Keywords

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