Natural killer cell immunoglobulin-like receptor (KIR) genotypes in follicular lymphoma patients: Results of a pilot study

Roy Khalaf; Rouba Hoteit; Soha Yazbek; Nady El Hajj; Zaher Otrock; Sarah Khansa; Amira Sabbagh; Dina Shammaa; Rami Mahfouz

doi:10.1016/j.gene.2013.03.144

Natural killer cell immunoglobulin-like receptor (KIR) genotypes in follicular lymphoma patients: Results of a pilot study

Roy Khalaf, Rouba Hoteit, Soha Yazbek, Nady El Hajj, Zaher Otrock, Sarah Khansa, Amira Sabbagh, Dina Shammaa, Rami Mahfouz^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Aims: The Natural Killer Cell Immunoglobulin-like Receptor (KIR) genotype profiling in Follicular Lymphoma has not been reported before in the literature. Materials and methods: DNA extracted from 20 Follicular Lymphoma patients and 62 healthy controls was analyzed for KIR genotyping using a polymerase chain reaction/sequence specific primers technique (PCR/SSP) for the presence of 16 KIR gene and pseudogene loci. Results: The AA, AB, and BB genotype frequencies were, respectively, 20%, 60% and 20% with an A:B ratio of 1:1. KIR 2DL4, KIR 3DL2, KIR 3DL3, and KIR 3DP1^*. 003 were presented in all individuals. No significant difference between patients and controls was detected. Conclusion: KIR genotyping profile does not seem to be associated with Follicular Lymphoma. The results presented in this pilot research represent the first international report about this important clinical entity.

Original language	English
Pages (from-to)	136-140
Number of pages	5
Journal	Gene
Volume	525
Issue number	1
DOIs	https://doi.org/10.1016/j.gene.2013.03.144
Publication status	Published - 1 Aug 2013
Externally published	Yes

Keywords

Follicular
Genotype
KIR
Lebanon
Lymphoma

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10.1016/j.gene.2013.03.144

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@article{d7f0aa30333e48ebb9e38c5a50bf2b89,

title = "Natural killer cell immunoglobulin-like receptor (KIR) genotypes in follicular lymphoma patients: Results of a pilot study",

abstract = "Aims: The Natural Killer Cell Immunoglobulin-like Receptor (KIR) genotype profiling in Follicular Lymphoma has not been reported before in the literature. Materials and methods: DNA extracted from 20 Follicular Lymphoma patients and 62 healthy controls was analyzed for KIR genotyping using a polymerase chain reaction/sequence specific primers technique (PCR/SSP) for the presence of 16 KIR gene and pseudogene loci. Results: The AA, AB, and BB genotype frequencies were, respectively, 20\%, 60\% and 20\% with an A:B ratio of 1:1. KIR 2DL4, KIR 3DL2, KIR 3DL3, and KIR 3DP1*. 003 were presented in all individuals. No significant difference between patients and controls was detected. Conclusion: KIR genotyping profile does not seem to be associated with Follicular Lymphoma. The results presented in this pilot research represent the first international report about this important clinical entity.",

keywords = "Follicular, Genotype, KIR, Lebanon, Lymphoma",

author = "Roy Khalaf and Rouba Hoteit and Soha Yazbek and \{El Hajj\}, Nady and Zaher Otrock and Sarah Khansa and Amira Sabbagh and Dina Shammaa and Rami Mahfouz",

year = "2013",

month = aug,

day = "1",

doi = "10.1016/j.gene.2013.03.144",

language = "English",

volume = "525",

pages = "136--140",

journal = "Gene",

issn = "0378-1119",

publisher = "Elsevier B.V.",

number = "1",

}

TY - JOUR

T1 - Natural killer cell immunoglobulin-like receptor (KIR) genotypes in follicular lymphoma patients

T2 - Results of a pilot study

AU - Khalaf, Roy

AU - Hoteit, Rouba

AU - Yazbek, Soha

AU - El Hajj, Nady

AU - Otrock, Zaher

AU - Khansa, Sarah

AU - Sabbagh, Amira

AU - Shammaa, Dina

AU - Mahfouz, Rami

PY - 2013/8/1

Y1 - 2013/8/1

N2 - Aims: The Natural Killer Cell Immunoglobulin-like Receptor (KIR) genotype profiling in Follicular Lymphoma has not been reported before in the literature. Materials and methods: DNA extracted from 20 Follicular Lymphoma patients and 62 healthy controls was analyzed for KIR genotyping using a polymerase chain reaction/sequence specific primers technique (PCR/SSP) for the presence of 16 KIR gene and pseudogene loci. Results: The AA, AB, and BB genotype frequencies were, respectively, 20%, 60% and 20% with an A:B ratio of 1:1. KIR 2DL4, KIR 3DL2, KIR 3DL3, and KIR 3DP1*. 003 were presented in all individuals. No significant difference between patients and controls was detected. Conclusion: KIR genotyping profile does not seem to be associated with Follicular Lymphoma. The results presented in this pilot research represent the first international report about this important clinical entity.

AB - Aims: The Natural Killer Cell Immunoglobulin-like Receptor (KIR) genotype profiling in Follicular Lymphoma has not been reported before in the literature. Materials and methods: DNA extracted from 20 Follicular Lymphoma patients and 62 healthy controls was analyzed for KIR genotyping using a polymerase chain reaction/sequence specific primers technique (PCR/SSP) for the presence of 16 KIR gene and pseudogene loci. Results: The AA, AB, and BB genotype frequencies were, respectively, 20%, 60% and 20% with an A:B ratio of 1:1. KIR 2DL4, KIR 3DL2, KIR 3DL3, and KIR 3DP1*. 003 were presented in all individuals. No significant difference between patients and controls was detected. Conclusion: KIR genotyping profile does not seem to be associated with Follicular Lymphoma. The results presented in this pilot research represent the first international report about this important clinical entity.

KW - Follicular

KW - Genotype

KW - KIR

KW - Lebanon

KW - Lymphoma

UR - https://www.scopus.com/pages/publications/84878876692

U2 - 10.1016/j.gene.2013.03.144

DO - 10.1016/j.gene.2013.03.144

M3 - Article

C2 - 23644024

AN - SCOPUS:84878876692

SN - 0378-1119

VL - 525

SP - 136

EP - 140

JO - Gene

JF - Gene

IS - 1

ER -

Natural killer cell immunoglobulin-like receptor (KIR) genotypes in follicular lymphoma patients: Results of a pilot study

Abstract

Keywords

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