TY - JOUR
T1 - Multimorbidity in dementia
T2 - Current perspectives and future challenges
AU - Stirland, Lucy E.
AU - Choate, Radmila
AU - Zanwar, Preeti Pushpalata
AU - Zhang, Panpan
AU - Watermeyer, Tamlyn J.
AU - Valletta, Martina
AU - Torso, Mario
AU - Tamburin, Stefano
AU - Saeed, Usman
AU - Ridgway, Gerard R.
AU - Moukaled, Shirine
AU - Lusk, Jay B.
AU - Loi, Samantha M.
AU - Littlejohns, Thomas J.
AU - Kuźma, Elżbieta
AU - James, Sarah Naomi
AU - Grande, Giulia
AU - Foote, Isabelle F.
AU - Cousins, Katheryn A.Q.
AU - Butler, Joe
AU - AbuHamdia, Abrar
AU - Avelino-Silva, Thiago J.
AU - Suryadevara, Vidyani
N1 - Publisher Copyright:
© 2025 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
PY - 2025/8
Y1 - 2025/8
N2 - Multimorbidity-the co-occurrence of two or more chronic health conditions-affects > 86% of people with dementia. It is associated with cognitive and functional decline, reduced health-related quality of life, increased health-care use, and higher mortality. The relationship between multimorbidity and dementia is potentially bidirectional; conditions such as hypertension and diabetes increase the risk of developing dementia, and cognitive impairment can complicate their management. This complexity presents challenges in health care and research, affecting treatment decisions and often leading to the exclusion of these individuals from clinical trials. Understanding multimorbidity through long-term prospective studies is crucial to clarify its relationship with dementia. Investigating specific disease combinations, environmental and genetic factors, and their impacts on cognitive health will guide the development of effective prediction models and inclusive intervention strategies for diverse global populations across the life course.
AB - Multimorbidity-the co-occurrence of two or more chronic health conditions-affects > 86% of people with dementia. It is associated with cognitive and functional decline, reduced health-related quality of life, increased health-care use, and higher mortality. The relationship between multimorbidity and dementia is potentially bidirectional; conditions such as hypertension and diabetes increase the risk of developing dementia, and cognitive impairment can complicate their management. This complexity presents challenges in health care and research, affecting treatment decisions and often leading to the exclusion of these individuals from clinical trials. Understanding multimorbidity through long-term prospective studies is crucial to clarify its relationship with dementia. Investigating specific disease combinations, environmental and genetic factors, and their impacts on cognitive health will guide the development of effective prediction models and inclusive intervention strategies for diverse global populations across the life course.
KW - All-cause dementia
KW - Comorbidity
KW - Multimorbidity
KW - Multiple long-term conditions
UR - https://www.scopus.com/pages/publications/105012387532
U2 - 10.1002/alz.70546
DO - 10.1002/alz.70546
M3 - Review article
C2 - 40755143
AN - SCOPUS:105012387532
SN - 1552-5260
VL - 21
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
IS - 8
M1 - e70546
ER -