Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis

Australian Asthma Genetics Consortium (AAGCGC); EArly Genetics and Lifecourse Epidemiology (EAGLEGLEGLE) Eczema Consortium

doi:10.1038/ng.3424

Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis

Australian Asthma Genetics Consortium (AAGCGC)
, EArly Genetics and Lifecourse Epidemiology (EAGLEGLEGLE) Eczema Consortium

Medical Research Council
University of Bristol
Helmholtz Zentrum München - German Research Center for Environmental Health
University of Copenhagen
University Hospital of Schleswig-Holstein
St. George’s Hospital
University of Manchester
23andMe Inc.
RIKEN
Max Delbrück Center for Molecular Medicine in the Helmholtz Association
Charité – Universitätsmedizin Berlin
Imperial College London
Erasmus University Rotterdam
Queensland Institute of Medical Research
Children's Hospital of Philadelphia
University of Pennsylvania
Anhui Medical University
Barcelona Institute for Global Health
Pompeu Fabra University
Biomedical Research Networking Center in Epidemiology and Public Health (CiberESP)
University of California at San Francisco
Centro de Investigacion Biomedica en Red Enfermedades Respiratorias (CIBERES)
Hospital Universitario Nuestra Senora de Candelaria
University of Groningen
Statens Serum Institut
Vrije Universiteit Amsterdam
King's College London
University of Western Australia
MRC Lifecourse Epidemiology Unit
Henry Ford Health System
Swiss Tropical and Public Health Institute
University of Basel
Centre for Genomic Regulation
University of Southampton
Sahlgrenska University Hospital
Icahn School of Medicine at Mount Sinai
The University of Chicago
Karolinska Institutet
University of Oxford
University of Queensland
Technische Universität Dresden
University of Greifswald
University of Bonn
Jülich Research Centre
University of Würzburg
German Centre for Cardiovascular Research
Kiel University
National Institute for Health and Welfare
University of Helsinki
University of Oulu
Research Centre for Prevention and Health
University of Sydney
Queen Elizabeth II Medical Centre Trust
University of Melbourne
Murdoch Children's Research Institute
Children’s Health Ireland
Trinity College Dublin
University of Dundee
Charles University
Pomeranian Medical University in Szczecin
Ludwig Maximilian University of Munich
University of Michigan, Ann Arbor
Newcastle University
Norwegian Institute of Public Health
Harvard University
Wake Forest University
Stockholm County Council
Hospital del Mar
University of Amsterdam
Stanford University

Research output: Contribution to journal › Article › peer-review

530 Citations (Scopus)

Abstract

Genetic association studies have identified 21 loci associated with atopic dermatitis risk predominantly in populations of European ancestry. To identify further susceptibility loci for this common, complex skin disease, we performed a meta-analysis of >15 million genetic variants in 21,399 cases and 95,464 controls from populations of European, African, Japanese and Latino ancestry, followed by replication in 32,059 cases and 228,628 controls from 18 studies. We identified ten new risk loci, bringing the total number of known atopic dermatitis risk loci to 31 (with new secondary signals at four of these loci). Notably, the new loci include candidate genes with roles in the regulation of innate host defenses and T cell function, underscoring the important contribution of (auto)immune mechanisms to atopic dermatitis pathogenesis.

Original language	English
Pages (from-to)	1449-1456
Number of pages	8
Journal	Nature Genetics
Volume	47
Issue number	12
DOIs	https://doi.org/10.1038/ng.3424
Publication status	Published - 1 Dec 2015
Externally published	Yes

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10.1038/ng.3424

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@article{f827d90cbcb24dc4bbad0fdee9b83742,

title = "Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis",

abstract = "Genetic association studies have identified 21 loci associated with atopic dermatitis risk predominantly in populations of European ancestry. To identify further susceptibility loci for this common, complex skin disease, we performed a meta-analysis of >15 million genetic variants in 21,399 cases and 95,464 controls from populations of European, African, Japanese and Latino ancestry, followed by replication in 32,059 cases and 228,628 controls from 18 studies. We identified ten new risk loci, bringing the total number of known atopic dermatitis risk loci to 31 (with new secondary signals at four of these loci). Notably, the new loci include candidate genes with roles in the regulation of innate host defenses and T cell function, underscoring the important contribution of (auto)immune mechanisms to atopic dermatitis pathogenesis.",

author = "\{Australian Asthma Genetics Consortium (AAGCGC)\} and \{EArly Genetics and Lifecourse Epidemiology (EAGLEGLEGLE) Eczema Consortium\} and Lavinia Paternoster and Marie Standl and Johannes Waage and Hansj{\"o}rg Baurecht and Melanie Hotze and Strachan, \{David P.\} and Curtin, \{John A.\} and Klaus B{\o}nnelykke and Chao Tian and Atsushi Takahashi and Jorge Esparza-Gordillo and Alves, \{Alexessander Couto\} and Thyssen, \{Jacob P.\} and \{Den Dekker\}, \{Herman T.\} and Ferreira, \{Manuel A.\} and Elisabeth Altmaier and Sleiman, \{Patrick M.A.\} and Xiao, \{Feng Li\} and Gonzalez, \{Juan R.\} and Ingo Marenholz and Birgit Kalb and Maria Pino-Yanes and Xu, \{Cheng Jian\} and Lisbeth Carstensen and Groen-Blokhuis, \{Maria M.\} and Cristina Venturini and Pennell, \{Craig E.\} and Barton, \{Sheila J.\} and Levin, \{Albert M.\} and Ivan Curjuric and Mariona Bustamante and Eskil Kreiner-M{\o}ller and Lockett, \{Gabrielle A.\} and Jonas Bacelis and Supinda Bunyavanich and Myers, \{Rachel A.\} and Anja Matanovic and Ashish Kumar and Tung, \{Joyce Y.\} and Tomomitsu Hirota and Michiaki Kubo and McArdle, \{Wendy L.\} and Henderson, \{A. John\} and Kemp, \{John P.\} and Jie Zheng and Smith, \{George Davey\} and Franz R{\"u}schendorf and Anja Bauerfeind and Lee-Kirsch, \{Min Ae\} and Hottenga, \{Jouke Jan\}",

year = "2015",

month = dec,

day = "1",

doi = "10.1038/ng.3424",

language = "English",

volume = "47",

pages = "1449--1456",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Research",

number = "12",

}

Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis. / Australian Asthma Genetics Consortium (AAGCGC); EArly Genetics and Lifecourse Epidemiology (EAGLEGLEGLE) Eczema Consortium.
In: Nature Genetics, Vol. 47, No. 12, 01.12.2015, p. 1449-1456.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis

AU - Australian Asthma Genetics Consortium (AAGCGC)

AU - EArly Genetics and Lifecourse Epidemiology (EAGLEGLEGLE) Eczema Consortium

AU - Paternoster, Lavinia

AU - Standl, Marie

AU - Waage, Johannes

AU - Baurecht, Hansjörg

AU - Hotze, Melanie

AU - Strachan, David P.

AU - Curtin, John A.

AU - Bønnelykke, Klaus

AU - Tian, Chao

AU - Takahashi, Atsushi

AU - Esparza-Gordillo, Jorge

AU - Alves, Alexessander Couto

AU - Thyssen, Jacob P.

AU - Den Dekker, Herman T.

AU - Ferreira, Manuel A.

AU - Altmaier, Elisabeth

AU - Sleiman, Patrick M.A.

AU - Xiao, Feng Li

AU - Gonzalez, Juan R.

AU - Marenholz, Ingo

AU - Kalb, Birgit

AU - Pino-Yanes, Maria

AU - Xu, Cheng Jian

AU - Carstensen, Lisbeth

AU - Groen-Blokhuis, Maria M.

AU - Venturini, Cristina

AU - Pennell, Craig E.

AU - Barton, Sheila J.

AU - Levin, Albert M.

AU - Curjuric, Ivan

AU - Bustamante, Mariona

AU - Kreiner-Møller, Eskil

AU - Lockett, Gabrielle A.

AU - Bacelis, Jonas

AU - Bunyavanich, Supinda

AU - Myers, Rachel A.

AU - Matanovic, Anja

AU - Kumar, Ashish

AU - Tung, Joyce Y.

AU - Hirota, Tomomitsu

AU - Kubo, Michiaki

AU - McArdle, Wendy L.

AU - Henderson, A. John

AU - Kemp, John P.

AU - Zheng, Jie

AU - Smith, George Davey

AU - Rüschendorf, Franz

AU - Bauerfeind, Anja

AU - Lee-Kirsch, Min Ae

AU - Hottenga, Jouke Jan

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Genetic association studies have identified 21 loci associated with atopic dermatitis risk predominantly in populations of European ancestry. To identify further susceptibility loci for this common, complex skin disease, we performed a meta-analysis of >15 million genetic variants in 21,399 cases and 95,464 controls from populations of European, African, Japanese and Latino ancestry, followed by replication in 32,059 cases and 228,628 controls from 18 studies. We identified ten new risk loci, bringing the total number of known atopic dermatitis risk loci to 31 (with new secondary signals at four of these loci). Notably, the new loci include candidate genes with roles in the regulation of innate host defenses and T cell function, underscoring the important contribution of (auto)immune mechanisms to atopic dermatitis pathogenesis.

AB - Genetic association studies have identified 21 loci associated with atopic dermatitis risk predominantly in populations of European ancestry. To identify further susceptibility loci for this common, complex skin disease, we performed a meta-analysis of >15 million genetic variants in 21,399 cases and 95,464 controls from populations of European, African, Japanese and Latino ancestry, followed by replication in 32,059 cases and 228,628 controls from 18 studies. We identified ten new risk loci, bringing the total number of known atopic dermatitis risk loci to 31 (with new secondary signals at four of these loci). Notably, the new loci include candidate genes with roles in the regulation of innate host defenses and T cell function, underscoring the important contribution of (auto)immune mechanisms to atopic dermatitis pathogenesis.

UR - https://www.scopus.com/pages/publications/84949087646

U2 - 10.1038/ng.3424

DO - 10.1038/ng.3424

M3 - Article

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AN - SCOPUS:84949087646

SN - 1061-4036

VL - 47

SP - 1449

EP - 1456

JO - Nature Genetics

JF - Nature Genetics

IS - 12

ER -

Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis

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