Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder

Y. Liu; D. H. Blackwood; S. Caesar; E. J.C. De Geus; A. Farmer; M. A.R. Ferreira; I. N. Ferrier; C. Fraser; K. Gordon-Smith; E. K. Green; D. Grozeva; H. M. Gurling; M. L. Hamshere; P. Heutink; P. A. Holmans; W. J. Hoogendijk; J. J. Hottenga; L. Jones; I. R. Jones; G. Kirov; D. Lin; P. McGuffin; V. Moskvina; W. A. Nolen; R. H. Perlis; D. Posthuma; E. M. Scolnick; A. B. Smit; J. H. Smit; J. W. Smoller; D. St Clair; R. Van Dyck; M. Verhage; G. Willemsen; A. H. Young; T. Zandbelt; D. I. Boomsma; N. Craddock; M. C. O'Donovan; M. J. Owen; B. W.J.H. Penninx; S. Purcell; P. Sklar; P. F. Sullivan

doi:10.1038/mp.2009.107

Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder

Y. Liu^*
, D. H. Blackwood
, S. Caesar
, E. J.C. De Geus
, A. Farmer
, M. A.R. Ferreira
, I. N. Ferrier
, C. Fraser
, K. Gordon-Smith
, E. K. Green
, D. Grozeva
, H. M. Gurling
, M. L. Hamshere
, P. Heutink
, P. A. Holmans
, W. J. Hoogendijk
, J. J. Hottenga
, L. Jones
, I. R. Jones
, G. Kirov

D. Lin, P. McGuffin, V. Moskvina, W. A. Nolen, R. H. Perlis, D. Posthuma, E. M. Scolnick, A. B. Smit, J. H. Smit, J. W. Smoller, D. St Clair, R. Van Dyck, M. Verhage, G. Willemsen, A. H. Young, T. Zandbelt, D. I. Boomsma, N. Craddock, M. C. O'Donovan, M. J. Owen, B. W.J.H. Penninx, S. Purcell, P. Sklar, P. F. Sullivan

^*Corresponding author for this work

Research output: Contribution to journal › Letter › peer-review

143 Citations (Scopus)

Abstract

Substantial indirect evidence suggests overlap between bipolar disorder (BIP) and major depressive disorder (MDD). BIP and MDD have in common major depressive episodes with BIP being distinguished by the additional presence of manic (bipolar 1) or hypomanic episodes (bipolar 2). Genetic epidemiological and genome-wide linkage studies are also consistent with overlap between genetic risk factors for both disorders. In an attempt to identify common genetic risk factors, we conducted a meta-analysis combining data from genome-wide association studies of BIP (4387 cases and 6209 controls) and MDD (1695 cases and 1761 controls).

Original language	English
Pages (from-to)	2-4
Number of pages	3
Journal	Molecular Psychiatry
Volume	16
Issue number	1
DOIs	https://doi.org/10.1038/mp.2009.107
Publication status	Published - Jan 2011
Externally published	Yes

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10.1038/mp.2009.107

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Liu, Y., Blackwood, D. H., Caesar, S., De Geus, E. J. C., Farmer, A., Ferreira, M. A. R., Ferrier, I. N., Fraser, C., Gordon-Smith, K., Green, E. K., Grozeva, D., Gurling, H. M., Hamshere, M. L., Heutink, P., Holmans, P. A., Hoogendijk, W. J., Hottenga, J. J., Jones, L., Jones, I. R., ... Sullivan, P. F. (2011). Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder. Molecular Psychiatry, 16(1), 2-4. https://doi.org/10.1038/mp.2009.107

@article{de61177c29254f02a4865b4b9350f543,

title = "Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder",

abstract = "Substantial indirect evidence suggests overlap between bipolar disorder (BIP) and major depressive disorder (MDD). BIP and MDD have in common major depressive episodes with BIP being distinguished by the additional presence of manic (bipolar 1) or hypomanic episodes (bipolar 2). Genetic epidemiological and genome-wide linkage studies are also consistent with overlap between genetic risk factors for both disorders. In an attempt to identify common genetic risk factors, we conducted a meta-analysis combining data from genome-wide association studies of BIP (4387 cases and 6209 controls) and MDD (1695 cases and 1761 controls).",

author = "Y. Liu and Blackwood, \{D. H.\} and S. Caesar and \{De Geus\}, \{E. J.C.\} and A. Farmer and Ferreira, \{M. A.R.\} and Ferrier, \{I. N.\} and C. Fraser and K. Gordon-Smith and Green, \{E. K.\} and D. Grozeva and Gurling, \{H. M.\} and Hamshere, \{M. L.\} and P. Heutink and Holmans, \{P. A.\} and Hoogendijk, \{W. J.\} and Hottenga, \{J. J.\} and L. Jones and Jones, \{I. R.\} and G. Kirov and D. Lin and P. McGuffin and V. Moskvina and Nolen, \{W. A.\} and Perlis, \{R. H.\} and D. Posthuma and Scolnick, \{E. M.\} and Smit, \{A. B.\} and Smit, \{J. H.\} and Smoller, \{J. W.\} and \{St Clair\}, D. and \{Van Dyck\}, R. and M. Verhage and G. Willemsen and Young, \{A. H.\} and T. Zandbelt and Boomsma, \{D. I.\} and N. Craddock and O'Donovan, \{M. C.\} and Owen, \{M. J.\} and Penninx, \{B. W.J.H.\} and S. Purcell and P. Sklar and Sullivan, \{P. F.\}",

year = "2011",

month = jan,

doi = "10.1038/mp.2009.107",

language = "English",

volume = "16",

pages = "2--4",

journal = "Molecular Psychiatry",

issn = "1359-4184",

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Liu, Y, Blackwood, DH, Caesar, S, De Geus, EJC, Farmer, A, Ferreira, MAR, Ferrier, IN, Fraser, C, Gordon-Smith, K, Green, EK, Grozeva, D, Gurling, HM, Hamshere, ML, Heutink, P, Holmans, PA, Hoogendijk, WJ, Hottenga, JJ, Jones, L, Jones, IR, Kirov, G, Lin, D, McGuffin, P, Moskvina, V, Nolen, WA, Perlis, RH, Posthuma, D, Scolnick, EM, Smit, AB, Smit, JH, Smoller, JW, St Clair, D, Van Dyck, R, Verhage, M, Willemsen, G, Young, AH, Zandbelt, T, Boomsma, DI, Craddock, N, O'Donovan, MC, Owen, MJ, Penninx, BWJH, Purcell, S, Sklar, P & Sullivan, PF 2011, 'Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder', Molecular Psychiatry, vol. 16, no. 1, pp. 2-4. https://doi.org/10.1038/mp.2009.107

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AU - Blackwood, D. H.

AU - Caesar, S.

AU - De Geus, E. J.C.

AU - Farmer, A.

AU - Ferreira, M. A.R.

AU - Ferrier, I. N.

AU - Fraser, C.

AU - Gordon-Smith, K.

AU - Green, E. K.

AU - Grozeva, D.

AU - Gurling, H. M.

AU - Hamshere, M. L.

AU - Heutink, P.

AU - Holmans, P. A.

AU - Hoogendijk, W. J.

AU - Hottenga, J. J.

AU - Jones, L.

AU - Jones, I. R.

AU - Kirov, G.

AU - Lin, D.

AU - McGuffin, P.

AU - Moskvina, V.

AU - Nolen, W. A.

AU - Perlis, R. H.

AU - Posthuma, D.

AU - Scolnick, E. M.

AU - Smit, A. B.

AU - Smit, J. H.

AU - Smoller, J. W.

AU - St Clair, D.

AU - Van Dyck, R.

AU - Verhage, M.

AU - Willemsen, G.

AU - Young, A. H.

AU - Zandbelt, T.

AU - Boomsma, D. I.

AU - Craddock, N.

AU - O'Donovan, M. C.

AU - Owen, M. J.

AU - Penninx, B. W.J.H.

AU - Purcell, S.

AU - Sklar, P.

AU - Sullivan, P. F.

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N2 - Substantial indirect evidence suggests overlap between bipolar disorder (BIP) and major depressive disorder (MDD). BIP and MDD have in common major depressive episodes with BIP being distinguished by the additional presence of manic (bipolar 1) or hypomanic episodes (bipolar 2). Genetic epidemiological and genome-wide linkage studies are also consistent with overlap between genetic risk factors for both disorders. In an attempt to identify common genetic risk factors, we conducted a meta-analysis combining data from genome-wide association studies of BIP (4387 cases and 6209 controls) and MDD (1695 cases and 1761 controls).

AB - Substantial indirect evidence suggests overlap between bipolar disorder (BIP) and major depressive disorder (MDD). BIP and MDD have in common major depressive episodes with BIP being distinguished by the additional presence of manic (bipolar 1) or hypomanic episodes (bipolar 2). Genetic epidemiological and genome-wide linkage studies are also consistent with overlap between genetic risk factors for both disorders. In an attempt to identify common genetic risk factors, we conducted a meta-analysis combining data from genome-wide association studies of BIP (4387 cases and 6209 controls) and MDD (1695 cases and 1761 controls).

UR - https://www.scopus.com/pages/publications/78650510203

U2 - 10.1038/mp.2009.107

DO - 10.1038/mp.2009.107

M3 - Letter

C2 - 20351715

AN - SCOPUS:78650510203

SN - 1359-4184

VL - 16

SP - 2

EP - 4

JO - Molecular Psychiatry

JF - Molecular Psychiatry

IS - 1

ER -

Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder

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