Lipidome atlas of the adult human brain

Maria Osetrova; Anna Tkachev; Waltraud Mair; Patricia Guijarro Larraz; Olga Efimova; Ilia Kurochkin; Elena Stekolshchikova; Nickolay Anikanov; Juat Chin Foo; Amaury Cazenave-Gassiot; Aleksandra Mitina; Polina Ogurtsova; Song Guo; Daria M. Potashnikova; Alexander A. Gulin; Alexander A. Vasin; Anastasia Sarycheva; Gleb Vladimirov; Maria Fedorova; Yury Kostyukevich; Evgeny Nikolaev; Markus R. Wenk; Ekaterina E. Khrameeva; Philipp Khaitovich

doi:10.1038/s41467-024-48734-y

Lipidome atlas of the adult human brain

Maria Osetrova
, Anna Tkachev
, Waltraud Mair
, Patricia Guijarro Larraz
, Olga Efimova
, Ilia Kurochkin
, Elena Stekolshchikova
, Nickolay Anikanov
, Juat Chin Foo
, Amaury Cazenave-Gassiot
, Aleksandra Mitina
, Polina Ogurtsova
, Song Guo
, Daria M. Potashnikova
, Alexander A. Gulin
, Alexander A. Vasin
, Anastasia Sarycheva
, Gleb Vladimirov
, Maria Fedorova
, Yury Kostyukevich

Evgeny Nikolaev, Markus R. Wenk^*, Ekaterina E. Khrameeva^*, Philipp Khaitovich^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

49 Citations (Scopus)

Abstract

Lipids are the most abundant but poorly explored components of the human brain. Here, we present a lipidome map of the human brain comprising 75 regions, including 52 neocortical ones. The lipidome composition varies greatly among the brain regions, affecting 93% of the 419 analyzed lipids. These differences reflect the brain’s structural characteristics, such as myelin content (345 lipids) and cell type composition (353 lipids), but also functional traits: functional connectivity (76 lipids) and information processing hierarchy (60 lipids). Combining lipid composition and mRNA expression data further enhances functional connectivity association. Biochemically, lipids linked with structural and functional brain features display distinct lipid class distribution, unsaturation extent, and prevalence of omega-3 and omega-6 fatty acid residues. We verified our conclusions by parallel analysis of three adult macaque brains, targeted analysis of 216 lipids, mass spectrometry imaging, and lipidome assessment of sorted murine neurons.

Original language	English
Article number	4455
Journal	Nature Communications
Volume	15
Issue number	1
DOIs	https://doi.org/10.1038/s41467-024-48734-y
Publication status	Published - Dec 2024
Externally published	Yes

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Osetrova, M., Tkachev, A., Mair, W., Guijarro Larraz, P., Efimova, O., Kurochkin, I., Stekolshchikova, E., Anikanov, N., Foo, J. C., Cazenave-Gassiot, A., Mitina, A., Ogurtsova, P., Guo, S., Potashnikova, D. M., Gulin, A. A., Vasin, A. A., Sarycheva, A., Vladimirov, G., Fedorova, M., ... Khaitovich, P. (2024). Lipidome atlas of the adult human brain. Nature Communications, 15(1), Article 4455. https://doi.org/10.1038/s41467-024-48734-y

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title = "Lipidome atlas of the adult human brain",

abstract = "Lipids are the most abundant but poorly explored components of the human brain. Here, we present a lipidome map of the human brain comprising 75 regions, including 52 neocortical ones. The lipidome composition varies greatly among the brain regions, affecting 93\% of the 419 analyzed lipids. These differences reflect the brain{\textquoteright}s structural characteristics, such as myelin content (345 lipids) and cell type composition (353 lipids), but also functional traits: functional connectivity (76 lipids) and information processing hierarchy (60 lipids). Combining lipid composition and mRNA expression data further enhances functional connectivity association. Biochemically, lipids linked with structural and functional brain features display distinct lipid class distribution, unsaturation extent, and prevalence of omega-3 and omega-6 fatty acid residues. We verified our conclusions by parallel analysis of three adult macaque brains, targeted analysis of 216 lipids, mass spectrometry imaging, and lipidome assessment of sorted murine neurons.",

author = "Maria Osetrova and Anna Tkachev and Waltraud Mair and \{Guijarro Larraz\}, Patricia and Olga Efimova and Ilia Kurochkin and Elena Stekolshchikova and Nickolay Anikanov and Foo, \{Juat Chin\} and Amaury Cazenave-Gassiot and Aleksandra Mitina and Polina Ogurtsova and Song Guo and Potashnikova, \{Daria M.\} and Gulin, \{Alexander A.\} and Vasin, \{Alexander A.\} and Anastasia Sarycheva and Gleb Vladimirov and Maria Fedorova and Yury Kostyukevich and Evgeny Nikolaev and Wenk, \{Markus R.\} and Khrameeva, \{Ekaterina E.\} and Philipp Khaitovich",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2024.",

year = "2024",

month = dec,

doi = "10.1038/s41467-024-48734-y",

language = "English",

volume = "15",

journal = "Nature Communications",

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Osetrova, M, Tkachev, A, Mair, W, Guijarro Larraz, P, Efimova, O, Kurochkin, I, Stekolshchikova, E, Anikanov, N, Foo, JC, Cazenave-Gassiot, A, Mitina, A, Ogurtsova, P, Guo, S, Potashnikova, DM, Gulin, AA, Vasin, AA, Sarycheva, A, Vladimirov, G, Fedorova, M, Kostyukevich, Y, Nikolaev, E, Wenk, MR, Khrameeva, EE & Khaitovich, P 2024, 'Lipidome atlas of the adult human brain', Nature Communications, vol. 15, no. 1, 4455. https://doi.org/10.1038/s41467-024-48734-y

TY - JOUR

T1 - Lipidome atlas of the adult human brain

AU - Osetrova, Maria

AU - Tkachev, Anna

AU - Mair, Waltraud

AU - Guijarro Larraz, Patricia

AU - Efimova, Olga

AU - Kurochkin, Ilia

AU - Stekolshchikova, Elena

AU - Anikanov, Nickolay

AU - Foo, Juat Chin

AU - Cazenave-Gassiot, Amaury

AU - Mitina, Aleksandra

AU - Ogurtsova, Polina

AU - Guo, Song

AU - Potashnikova, Daria M.

AU - Gulin, Alexander A.

AU - Vasin, Alexander A.

AU - Sarycheva, Anastasia

AU - Vladimirov, Gleb

AU - Fedorova, Maria

AU - Kostyukevich, Yury

AU - Nikolaev, Evgeny

AU - Wenk, Markus R.

AU - Khrameeva, Ekaterina E.

AU - Khaitovich, Philipp

PY - 2024/12

Y1 - 2024/12

N2 - Lipids are the most abundant but poorly explored components of the human brain. Here, we present a lipidome map of the human brain comprising 75 regions, including 52 neocortical ones. The lipidome composition varies greatly among the brain regions, affecting 93% of the 419 analyzed lipids. These differences reflect the brain’s structural characteristics, such as myelin content (345 lipids) and cell type composition (353 lipids), but also functional traits: functional connectivity (76 lipids) and information processing hierarchy (60 lipids). Combining lipid composition and mRNA expression data further enhances functional connectivity association. Biochemically, lipids linked with structural and functional brain features display distinct lipid class distribution, unsaturation extent, and prevalence of omega-3 and omega-6 fatty acid residues. We verified our conclusions by parallel analysis of three adult macaque brains, targeted analysis of 216 lipids, mass spectrometry imaging, and lipidome assessment of sorted murine neurons.

AB - Lipids are the most abundant but poorly explored components of the human brain. Here, we present a lipidome map of the human brain comprising 75 regions, including 52 neocortical ones. The lipidome composition varies greatly among the brain regions, affecting 93% of the 419 analyzed lipids. These differences reflect the brain’s structural characteristics, such as myelin content (345 lipids) and cell type composition (353 lipids), but also functional traits: functional connectivity (76 lipids) and information processing hierarchy (60 lipids). Combining lipid composition and mRNA expression data further enhances functional connectivity association. Biochemically, lipids linked with structural and functional brain features display distinct lipid class distribution, unsaturation extent, and prevalence of omega-3 and omega-6 fatty acid residues. We verified our conclusions by parallel analysis of three adult macaque brains, targeted analysis of 216 lipids, mass spectrometry imaging, and lipidome assessment of sorted murine neurons.

UR - https://www.scopus.com/pages/publications/85194418935

U2 - 10.1038/s41467-024-48734-y

DO - 10.1038/s41467-024-48734-y

M3 - Article

C2 - 38796479

AN - SCOPUS:85194418935

SN - 2041-1723

VL - 15

JO - Nature Communications

JF - Nature Communications

IS - 1

M1 - 4455

ER -

Lipidome atlas of the adult human brain

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