TY - JOUR
T1 - Life stage impact on the human skin ecosystem
T2 - lipids and the microbial community
AU - Pagac, Martin P.
AU - Davient, Bala
AU - Plado, Luca Antonio
AU - Lam, Hilbert Yuen In
AU - Lee, Shi Mun
AU - Ravikrishnan, Aarthi
AU - Chua, Wee Ling Esther
AU - Muralidharan, Sneha
AU - Sridharan, Aishwarya
AU - Irudayaswamy, Antony S.
AU - Srinivas, Ramasamy
AU - Wearne, Stephen
AU - Mohamed Naim, Ahmad Nazri
AU - Ho, Eliza Xin Pei
AU - Ng, H. Q.Amanda
AU - Kwah, Junmei Samantha
AU - Png, Eileen
AU - Bendt, Anne K.
AU - Wenk, Markus R.
AU - Torta, Federico
AU - Nagarajan, Niranjan
AU - Common, John
AU - Chong, Yap Seng
AU - Tham, Elizabeth Huiwen
AU - Shek, Lynette Pei Chi
AU - Loo, Evelyn Xiu Ling
AU - Chambers, John
AU - Yew, Yik Weng
AU - Loh, Marie
AU - Dawson, Thomas L.
N1 - Publisher Copyright:
© The Author(s) 2025.
PY - 2025/12
Y1 - 2025/12
N2 - Sebaceous free fatty acids are metabolized by multiple skin microbes into bioactive lipid mediators termed oxylipins. This study investigated correlations between skin oxylipins and microbes on the superficial skin of pre-pubescent children (N = 36) and adults (N = 100), including pre- (N = 25) and post-menopausal females (N = 25). Lipidomics and metagenomics revealed that Malassezia restricta positively correlated with the oxylipin 9,10-DiHOME on adult skin and negatively correlated with its precursor, 9,10-EpOME, on pre-pubescent skin. Co-culturing Malassezia with keratinocytes demonstrated a link between 9,10-DiHOME and pro-inflammatory cytokines IL-1β and IL-6 production. We also observed strong correlations between other skin oxylipins and microbial taxa, highlighting life stage differences in sebum production and microbial community composition. Our findings imply a complex host-microbe communication system mediated by lipid metabolism occurring on human skin, warranting further research into its role in skin health and disease and paving the way towards novel therapeutic targets and treatments.
AB - Sebaceous free fatty acids are metabolized by multiple skin microbes into bioactive lipid mediators termed oxylipins. This study investigated correlations between skin oxylipins and microbes on the superficial skin of pre-pubescent children (N = 36) and adults (N = 100), including pre- (N = 25) and post-menopausal females (N = 25). Lipidomics and metagenomics revealed that Malassezia restricta positively correlated with the oxylipin 9,10-DiHOME on adult skin and negatively correlated with its precursor, 9,10-EpOME, on pre-pubescent skin. Co-culturing Malassezia with keratinocytes demonstrated a link between 9,10-DiHOME and pro-inflammatory cytokines IL-1β and IL-6 production. We also observed strong correlations between other skin oxylipins and microbial taxa, highlighting life stage differences in sebum production and microbial community composition. Our findings imply a complex host-microbe communication system mediated by lipid metabolism occurring on human skin, warranting further research into its role in skin health and disease and paving the way towards novel therapeutic targets and treatments.
UR - https://www.scopus.com/pages/publications/85215355382
U2 - 10.1038/s41522-025-00652-7
DO - 10.1038/s41522-025-00652-7
M3 - Article
C2 - 39800795
AN - SCOPUS:85215355382
SN - 2055-5008
VL - 11
JO - npj Biofilms and Microbiomes
JF - npj Biofilms and Microbiomes
IS - 1
M1 - 13
ER -