Implications for lipids during replication of enveloped viruses

Robin B. Chan; Lukas Tanner; Markus R. Wenk

doi:10.1016/j.chemphyslip.2010.03.002

Implications for lipids during replication of enveloped viruses

Robin B. Chan, Lukas Tanner, Markus R. Wenk

National University of Singapore

Research output: Contribution to journal › Review article › peer-review

43 Citations (Scopus)

Abstract

Enveloped viruses, which include many medically important viruses such as human immunodeficiency virus, influenza virus and hepatitis C virus, are intracellular parasites that acquire lipid envelopes from their host cells. Success of replication is intimately linked to their ability to hijack host cell mechanisms, particularly those related to membrane dynamics and lipid metabolism. Despite recent progress, our knowledge of lipid mediated virus-host interactions remains highly incomplete. In addition, diverse experimental systems are used to study different stages of virus replication thus complicating comparisons. This review aims to present a unifying view of the widely diverse strategies used by enveloped viruses at distinct stages of their replication cycles.

Original language	English
Pages (from-to)	449-459
Number of pages	11
Journal	Chemistry and Physics of Lipids
Volume	163
Issue number	6
DOIs	https://doi.org/10.1016/j.chemphyslip.2010.03.002
Publication status	Published - Jun 2010
Externally published	Yes

Keywords

Enveloped virus
Glycolipid
Lipid-protein interactions
Lipidomics
Membrane
Receptor

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10.1016/j.chemphyslip.2010.03.002

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title = "Implications for lipids during replication of enveloped viruses",

abstract = "Enveloped viruses, which include many medically important viruses such as human immunodeficiency virus, influenza virus and hepatitis C virus, are intracellular parasites that acquire lipid envelopes from their host cells. Success of replication is intimately linked to their ability to hijack host cell mechanisms, particularly those related to membrane dynamics and lipid metabolism. Despite recent progress, our knowledge of lipid mediated virus-host interactions remains highly incomplete. In addition, diverse experimental systems are used to study different stages of virus replication thus complicating comparisons. This review aims to present a unifying view of the widely diverse strategies used by enveloped viruses at distinct stages of their replication cycles.",

keywords = "Enveloped virus, Glycolipid, Lipid-protein interactions, Lipidomics, Membrane, Receptor",

author = "Chan, \{Robin B.\} and Lukas Tanner and Wenk, \{Markus R.\}",

year = "2010",

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T1 - Implications for lipids during replication of enveloped viruses

AU - Chan, Robin B.

AU - Tanner, Lukas

AU - Wenk, Markus R.

PY - 2010/6

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N2 - Enveloped viruses, which include many medically important viruses such as human immunodeficiency virus, influenza virus and hepatitis C virus, are intracellular parasites that acquire lipid envelopes from their host cells. Success of replication is intimately linked to their ability to hijack host cell mechanisms, particularly those related to membrane dynamics and lipid metabolism. Despite recent progress, our knowledge of lipid mediated virus-host interactions remains highly incomplete. In addition, diverse experimental systems are used to study different stages of virus replication thus complicating comparisons. This review aims to present a unifying view of the widely diverse strategies used by enveloped viruses at distinct stages of their replication cycles.

AB - Enveloped viruses, which include many medically important viruses such as human immunodeficiency virus, influenza virus and hepatitis C virus, are intracellular parasites that acquire lipid envelopes from their host cells. Success of replication is intimately linked to their ability to hijack host cell mechanisms, particularly those related to membrane dynamics and lipid metabolism. Despite recent progress, our knowledge of lipid mediated virus-host interactions remains highly incomplete. In addition, diverse experimental systems are used to study different stages of virus replication thus complicating comparisons. This review aims to present a unifying view of the widely diverse strategies used by enveloped viruses at distinct stages of their replication cycles.

KW - Enveloped virus

KW - Glycolipid

KW - Lipid-protein interactions

KW - Lipidomics

KW - Membrane

KW - Receptor

UR - https://www.scopus.com/pages/publications/77954215846

U2 - 10.1016/j.chemphyslip.2010.03.002

DO - 10.1016/j.chemphyslip.2010.03.002

M3 - Review article

C2 - 20230810

AN - SCOPUS:77954215846

SN - 0009-3084

VL - 163

SP - 449

EP - 459

JO - Chemistry and Physics of Lipids

JF - Chemistry and Physics of Lipids

IS - 6

ER -

Implications for lipids during replication of enveloped viruses

Abstract

Keywords

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