Human induced pluripotent stem cells generated from epilepsy patients for use as in vitro models for drug screening

Zoe L. Hunter; Hannah C. Leeson; Mohammed R. Shaker; Ernst J. Wolvetang; Lata Vadlamudi

doi:10.1016/j.scr.2022.102673

Human induced pluripotent stem cells generated from epilepsy patients for use as in vitro models for drug screening

Zoe L. Hunter
, Hannah C. Leeson
, Mohammed R. Shaker
, Ernst J. Wolvetang^*
, Lata Vadlamudi

^*Corresponding author for this work

University of Queensland
Royal Brisbane and Women's Hospital

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

In this paper, we describe the generation and validation of human induced pluripotent stem cell (hiPSC) lines from peripheral blood mononuclear cells (PBMCs) from 6 epilepsy patients using a non-integrative Sendai virus vector. These human cellular models will enable patient-specific drug screening to improve outcomes for individuals with this disorder.

Original language	English
Article number	102673
Journal	Stem Cell Research
Volume	60
Early online date	Jan 2022
DOIs	https://doi.org/10.1016/j.scr.2022.102673
Publication status	Published - Apr 2022
Externally published	Yes

Access to Document

10.1016/j.scr.2022.102673

Cite this

@article{0f1352239cd341108613af3e302680ec,

title = "Human induced pluripotent stem cells generated from epilepsy patients for use as in vitro models for drug screening",

abstract = "In this paper, we describe the generation and validation of human induced pluripotent stem cell (hiPSC) lines from peripheral blood mononuclear cells (PBMCs) from 6 epilepsy patients using a non-integrative Sendai virus vector. These human cellular models will enable patient-specific drug screening to improve outcomes for individuals with this disorder.",

author = "Hunter, \{Zoe L.\} and Leeson, \{Hannah C.\} and Shaker, \{Mohammed R.\} and Wolvetang, \{Ernst J.\} and Lata Vadlamudi",

note = "Publisher Copyright: {\textcopyright} 2022 The Author(s)",

year = "2022",

month = apr,

doi = "10.1016/j.scr.2022.102673",

language = "English",

volume = "60",

journal = "Stem Cell Research",

issn = "1873-5061",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Human induced pluripotent stem cells generated from epilepsy patients for use as in vitro models for drug screening

AU - Hunter, Zoe L.

AU - Leeson, Hannah C.

AU - Shaker, Mohammed R.

AU - Wolvetang, Ernst J.

AU - Vadlamudi, Lata

PY - 2022/4

Y1 - 2022/4

N2 - In this paper, we describe the generation and validation of human induced pluripotent stem cell (hiPSC) lines from peripheral blood mononuclear cells (PBMCs) from 6 epilepsy patients using a non-integrative Sendai virus vector. These human cellular models will enable patient-specific drug screening to improve outcomes for individuals with this disorder.

AB - In this paper, we describe the generation and validation of human induced pluripotent stem cell (hiPSC) lines from peripheral blood mononuclear cells (PBMCs) from 6 epilepsy patients using a non-integrative Sendai virus vector. These human cellular models will enable patient-specific drug screening to improve outcomes for individuals with this disorder.

UR - https://www.scopus.com/pages/publications/85123160847

U2 - 10.1016/j.scr.2022.102673

DO - 10.1016/j.scr.2022.102673

M3 - Article

C2 - 35074713

AN - SCOPUS:85123160847

SN - 1873-5061

VL - 60

JO - Stem Cell Research

JF - Stem Cell Research

M1 - 102673

ER -

Human induced pluripotent stem cells generated from epilepsy patients for use as in vitro models for drug screening

Abstract

Access to Document

Other files and links

Fingerprint

Cite this