Human induced pluripotent stem cells generated from epilepsy patients for use as in vitro models for drug screening

Zoe L. Hunter; Hannah C. Leeson; Mohammed R. Shaker; Ernst J. Wolvetang; Lata Vadlamudi

doi:10.1016/j.scr.2022.102673

Human induced pluripotent stem cells generated from epilepsy patients for use as in vitro models for drug screening

Zoe L. Hunter
, Hannah C. Leeson
, Mohammed R. Shaker
, Ernst J. Wolvetang^*
, Lata Vadlamudi

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

In this paper, we describe the generation and validation of human induced pluripotent stem cell (hiPSC) lines from peripheral blood mononuclear cells (PBMCs) from 6 epilepsy patients using a non-integrative Sendai virus vector. These human cellular models will enable patient-specific drug screening to improve outcomes for individuals with this disorder.

Original language	English
Article number	102673
Journal	Stem Cell Research
Volume	60
Early online date	Jan 2022
DOIs	https://doi.org/10.1016/j.scr.2022.102673
Publication status	Published - Apr 2022
Externally published	Yes

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title = "Human induced pluripotent stem cells generated from epilepsy patients for use as in vitro models for drug screening",

abstract = "In this paper, we describe the generation and validation of human induced pluripotent stem cell (hiPSC) lines from peripheral blood mononuclear cells (PBMCs) from 6 epilepsy patients using a non-integrative Sendai virus vector. These human cellular models will enable patient-specific drug screening to improve outcomes for individuals with this disorder.",

author = "Hunter, \{Zoe L.\} and Leeson, \{Hannah C.\} and Shaker, \{Mohammed R.\} and Wolvetang, \{Ernst J.\} and Lata Vadlamudi",

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AU - Shaker, Mohammed R.

AU - Wolvetang, Ernst J.

AU - Vadlamudi, Lata

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AB - In this paper, we describe the generation and validation of human induced pluripotent stem cell (hiPSC) lines from peripheral blood mononuclear cells (PBMCs) from 6 epilepsy patients using a non-integrative Sendai virus vector. These human cellular models will enable patient-specific drug screening to improve outcomes for individuals with this disorder.

UR - https://www.scopus.com/pages/publications/85123160847

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JO - Stem Cell Research

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Human induced pluripotent stem cells generated from epilepsy patients for use as in vitro models for drug screening

Abstract

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