Genomic Dissection of Pediatric Protein-Losing Enteropathy and Related Disorders: Clinical, Immunologic, and Therapeutic Insights

Asena Pinar Sefer; Baran Erman; Safa Baris; Elif Karakoc-Aydiner; Emine Selva Aydogdu; Simanur Cevahir; Salim Can; Alper Bulutoglu; Satanay Hubrack; Katherine Whitmore; Melanie Makhlouf; Luis R. Saraiva; Gizem Onder; Ozden Hatirnaz; Ali İslek; Omer Faruk Beser; Deniz Ertem; Ayca Kiykim; Ertugrul Kiykim; Aysel Unlusoy Aksu; Gokhan Baysoy; Nafiye Urganci; Neslihan Eksi Bozbulut; Omur Ardeniz; Gunsel Kutluk; Ebru Arik Yilmaz; Nevzat Aykut Bayrak; Sevgi Bilgic Eltan; Merve Selçuk; Dilek Baser; Gamze Akgun; Burak Demirkaya; Feyza Bayram Catak; Mustafa Cavusoglu; Reyhan Gumusburun; Mahmut Esat Tuluce; Gokhan Tumgor; Dilek Guller; Ceyda Tunakan Dalgic; Fatma Ilknur Varol; Esra Karabiber; Arzu Meltem Demir; Melek Yorgun Altunbas; Ezgi Yalcin Gungoren; Merve Usta; Bilge Sahin Akkelle; Jonathan Lyons; Megan Fisher; Sinan Sari; Buket Dalgic; Odul Egritas; Engin Tutar; Duygu Somen Bayoglu; Yu Zhang; Burcu Guven; Sibel Yavuz; Ayse Burcum Sertel; Tugba Gursoy Koca; Demet Teker Duztas; Ahmet Basturk; Fatma Demirbas Ar; Umran Aba; Ceren Bozkurt; Kutay Erdogan; Rabia Ergelen; Figen Ozcay; Feyza Kabar; Burcu Volkan; Yasemin Kendirli; Fügen Çullu Çokuğraş; Tufan Kutlu; Bernice Lo; Ahmet Ozen

doi:10.1053/j.gastro.2025.10.022

Genomic Dissection of Pediatric Protein-Losing Enteropathy and Related Disorders: Clinical, Immunologic, and Therapeutic Insights

Asena Pinar Sefer
, Baran Erman
, Safa Baris
, Elif Karakoc-Aydiner
, Emine Selva Aydogdu
, Simanur Cevahir
, Salim Can
, Alper Bulutoglu
, Satanay Hubrack
, Katherine Whitmore
, Melanie Makhlouf
, Luis R. Saraiva
, Gizem Onder
, Ozden Hatirnaz
, Ali İslek
, Omer Faruk Beser
, Deniz Ertem
, Ayca Kiykim
, Ertugrul Kiykim
, Aysel Unlusoy Aksu

Gokhan Baysoy, Nafiye Urganci, Neslihan Eksi Bozbulut, Omur Ardeniz, Gunsel Kutluk, Ebru Arik Yilmaz, Nevzat Aykut Bayrak, Sevgi Bilgic Eltan, Merve Selçuk, Dilek Baser, Gamze Akgun, Burak Demirkaya, Feyza Bayram Catak, Mustafa Cavusoglu, Reyhan Gumusburun, Mahmut Esat Tuluce, Gokhan Tumgor, Dilek Guller, Ceyda Tunakan Dalgic, Fatma Ilknur Varol, Esra Karabiber, Arzu Meltem Demir, Melek Yorgun Altunbas, Ezgi Yalcin Gungoren, Merve Usta, Bilge Sahin Akkelle, Jonathan Lyons, Megan Fisher, Sinan Sari, Buket Dalgic, Odul Egritas, Engin Tutar, Duygu Somen Bayoglu, Yu Zhang, Burcu Guven, Sibel Yavuz, Ayse Burcum Sertel, Tugba Gursoy Koca, Demet Teker Duztas, Ahmet Basturk, Fatma Demirbas Ar, Umran Aba, Ceren Bozkurt, Kutay Erdogan, Rabia Ergelen, Figen Ozcay, Feyza Kabar, Burcu Volkan, Yasemin Kendirli, Fügen Çullu Çokuğraş, Tufan Kutlu, Bernice Lo, Ahmet Ozen^*

^*Corresponding author for this work

HBKU College of Health & Life Sciences

Recep Tayyip Erdogan University
Hacettepe University
Marmara University
The Isil Berat Barlan Center for Translational Medicine
Istanbul Jeffrey Modell Diagnostic and Research Center for Primary Immunodeficiencies
Sidra Medicine
Yale University
HBKU College of Health and Life Sciences
Acibadem Mehmet Ali Aydinlar Universitesi
Cukurova University
Istanbul University - Cerrahpaşa
University of Health Sciences
Istanbul Medipol University
Sarıyer Hamidiye Etfal Training and Research Hospital
Ege University
Istanbul Başakşehir Çam and Sakura City Hospital
Pamukkale University
Inonu University
Ankara University
University of California at San Diego
Department of Veterans Affairs
National Institutes of Health
Gazi University
Umraniye Training and Research Hospital
Karadeniz Technical University
Adana City Training and Research Hospital
Kocaeli City Hospital
Gaziantep University
Balıkesir Atatürk City Hospital
Koc University
Baskent University
Bursa City Hospital

Research output: Contribution to journal › Editorial

Original language	English
Pages (from-to)	821-825
Number of pages	5
Journal	Gastroenterology
Volume	170
Issue number	4
DOIs	https://doi.org/10.1053/j.gastro.2025.10.022
Publication status	Published - Apr 2026

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10.1053/j.gastro.2025.10.022

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Sefer, A. P., Erman, B., Baris, S., Karakoc-Aydiner, E., Aydogdu, E. S., Cevahir, S., Can, S., Bulutoglu, A., Hubrack, S., Whitmore, K., Makhlouf, M., Saraiva, L. R., Onder, G., Hatirnaz, O., İslek, A., Beser, O. F., Ertem, D., Kiykim, A., Kiykim, E., ... Ozen, A. (2026). Genomic Dissection of Pediatric Protein-Losing Enteropathy and Related Disorders: Clinical, Immunologic, and Therapeutic Insights. Gastroenterology, 170(4), 821-825. https://doi.org/10.1053/j.gastro.2025.10.022

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title = "Genomic Dissection of Pediatric Protein-Losing Enteropathy and Related Disorders: Clinical, Immunologic, and Therapeutic Insights",

author = "Sefer, \{Asena Pinar\} and Baran Erman and Safa Baris and Elif Karakoc-Aydiner and Aydogdu, \{Emine Selva\} and Simanur Cevahir and Salim Can and Alper Bulutoglu and Satanay Hubrack and Katherine Whitmore and Melanie Makhlouf and Saraiva, \{Luis R.\} and Gizem Onder and Ozden Hatirnaz and Ali İslek and Beser, \{Omer Faruk\} and Deniz Ertem and Ayca Kiykim and Ertugrul Kiykim and Aksu, \{Aysel Unlusoy\} and Gokhan Baysoy and Nafiye Urganci and Bozbulut, \{Neslihan Eksi\} and Omur Ardeniz and Gunsel Kutluk and Yilmaz, \{Ebru Arik\} and Bayrak, \{Nevzat Aykut\} and Eltan, \{Sevgi Bilgic\} and Merve Sel{\c c}uk and Dilek Baser and Gamze Akgun and Burak Demirkaya and Catak, \{Feyza Bayram\} and Mustafa Cavusoglu and Reyhan Gumusburun and Tuluce, \{Mahmut Esat\} and Gokhan Tumgor and Dilek Guller and Dalgic, \{Ceyda Tunakan\} and Varol, \{Fatma Ilknur\} and Esra Karabiber and Demir, \{Arzu Meltem\} and Altunbas, \{Melek Yorgun\} and Gungoren, \{Ezgi Yalcin\} and Merve Usta and Akkelle, \{Bilge Sahin\} and Jonathan Lyons and Megan Fisher and Sinan Sari and Buket Dalgic and Odul Egritas and Engin Tutar and Bayoglu, \{Duygu Somen\} and Yu Zhang and Burcu Guven and Sibel Yavuz and Sertel, \{Ayse Burcum\} and Koca, \{Tugba Gursoy\} and Duztas, \{Demet Teker\} and Ahmet Basturk and Ar, \{Fatma Demirbas\} and Umran Aba and Ceren Bozkurt and Kutay Erdogan and Rabia Ergelen and Figen Ozcay and Feyza Kabar and Burcu Volkan and Yasemin Kendirli and {\c C}okuğra{\c s}, \{F{\"u}gen {\c C}ullu\} and Tufan Kutlu and Bernice Lo and Ahmet Ozen",

year = "2026",

month = apr,

doi = "10.1053/j.gastro.2025.10.022",

language = "English",

volume = "170",

pages = "821--825",

journal = "Gastroenterology",

issn = "0016-5085",

publisher = "W.B. Saunders",

number = "4",

}

Sefer, AP, Erman, B, Baris, S, Karakoc-Aydiner, E, Aydogdu, ES, Cevahir, S, Can, S, Bulutoglu, A, Hubrack, S, Whitmore, K, Makhlouf, M, Saraiva, LR, Onder, G, Hatirnaz, O, İslek, A, Beser, OF, Ertem, D, Kiykim, A, Kiykim, E, Aksu, AU, Baysoy, G, Urganci, N, Bozbulut, NE, Ardeniz, O, Kutluk, G, Yilmaz, EA, Bayrak, NA, Eltan, SB, Selçuk, M, Baser, D, Akgun, G, Demirkaya, B, Catak, FB, Cavusoglu, M, Gumusburun, R, Tuluce, ME, Tumgor, G, Guller, D, Dalgic, CT, Varol, FI, Karabiber, E, Demir, AM, Altunbas, MY, Gungoren, EY, Usta, M, Akkelle, BS, Lyons, J, Fisher, M, Sari, S, Dalgic, B, Egritas, O, Tutar, E, Bayoglu, DS, Zhang, Y, Guven, B, Yavuz, S, Sertel, AB, Koca, TG, Duztas, DT, Basturk, A, Ar, FD, Aba, U, Bozkurt, C, Erdogan, K, Ergelen, R, Ozcay, F, Kabar, F, Volkan, B, Kendirli, Y, Çokuğraş, FÇ, Kutlu, T, Lo, B & Ozen, A 2026, 'Genomic Dissection of Pediatric Protein-Losing Enteropathy and Related Disorders: Clinical, Immunologic, and Therapeutic Insights', Gastroenterology, vol. 170, no. 4, pp. 821-825. https://doi.org/10.1053/j.gastro.2025.10.022

TY - JOUR

T1 - Genomic Dissection of Pediatric Protein-Losing Enteropathy and Related Disorders

T2 - Clinical, Immunologic, and Therapeutic Insights

AU - Sefer, Asena Pinar

AU - Erman, Baran

AU - Baris, Safa

AU - Karakoc-Aydiner, Elif

AU - Aydogdu, Emine Selva

AU - Cevahir, Simanur

AU - Can, Salim

AU - Bulutoglu, Alper

AU - Hubrack, Satanay

AU - Whitmore, Katherine

AU - Makhlouf, Melanie

AU - Saraiva, Luis R.

AU - Onder, Gizem

AU - Hatirnaz, Ozden

AU - İslek, Ali

AU - Beser, Omer Faruk

AU - Ertem, Deniz

AU - Kiykim, Ayca

AU - Kiykim, Ertugrul

AU - Aksu, Aysel Unlusoy

AU - Baysoy, Gokhan

AU - Urganci, Nafiye

AU - Bozbulut, Neslihan Eksi

AU - Ardeniz, Omur

AU - Kutluk, Gunsel

AU - Yilmaz, Ebru Arik

AU - Bayrak, Nevzat Aykut

AU - Eltan, Sevgi Bilgic

AU - Selçuk, Merve

AU - Baser, Dilek

AU - Akgun, Gamze

AU - Demirkaya, Burak

AU - Catak, Feyza Bayram

AU - Cavusoglu, Mustafa

AU - Gumusburun, Reyhan

AU - Tuluce, Mahmut Esat

AU - Tumgor, Gokhan

AU - Guller, Dilek

AU - Dalgic, Ceyda Tunakan

AU - Varol, Fatma Ilknur

AU - Karabiber, Esra

AU - Demir, Arzu Meltem

AU - Altunbas, Melek Yorgun

AU - Gungoren, Ezgi Yalcin

AU - Usta, Merve

AU - Akkelle, Bilge Sahin

AU - Lyons, Jonathan

AU - Fisher, Megan

AU - Sari, Sinan

AU - Dalgic, Buket

AU - Egritas, Odul

AU - Tutar, Engin

AU - Bayoglu, Duygu Somen

AU - Zhang, Yu

AU - Guven, Burcu

AU - Yavuz, Sibel

AU - Sertel, Ayse Burcum

AU - Koca, Tugba Gursoy

AU - Duztas, Demet Teker

AU - Basturk, Ahmet

AU - Ar, Fatma Demirbas

AU - Aba, Umran

AU - Bozkurt, Ceren

AU - Erdogan, Kutay

AU - Ergelen, Rabia

AU - Ozcay, Figen

AU - Kabar, Feyza

AU - Volkan, Burcu

AU - Kendirli, Yasemin

AU - Çokuğraş, Fügen Çullu

AU - Kutlu, Tufan

AU - Lo, Bernice

AU - Ozen, Ahmet

PY - 2026/4

Y1 - 2026/4

UR - https://www.scopus.com/pages/publications/105034208618

U2 - 10.1053/j.gastro.2025.10.022

DO - 10.1053/j.gastro.2025.10.022

M3 - Editorial

C2 - 41686101

AN - SCOPUS:105034208618

SN - 0016-5085

VL - 170

SP - 821

EP - 825

JO - Gastroenterology

JF - Gastroenterology

IS - 4

ER -

Genomic Dissection of Pediatric Protein-Losing Enteropathy and Related Disorders: Clinical, Immunologic, and Therapeutic Insights

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