TY - JOUR
T1 - Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults
AU - CHARGE consortium
AU - EPIC-InterAct Consortium
AU - PAGE Consortium
AU - Graff, Mariaelisa
AU - Scott, Robert A.
AU - Justice, Anne E.
AU - Young, Kristin L.
AU - Feitosa, Mary F.
AU - Barata, Llilda
AU - Winkler, Thomas W.
AU - Chu, Audrey Y.
AU - Mahajan, Anubha
AU - Hadley, David
AU - Xue, Luting
AU - Workalemahu, Tsegaselassie
AU - Heard-Costa, Nancy L.
AU - den Hoed, Marcel
AU - Ahluwalia, Tarunveer S.
AU - Qi, Qibin
AU - Ngwa, Julius S.
AU - Renström, Frida
AU - Quaye, Lydia
AU - Eicher, John D.
AU - Hayes, James E.
AU - Cornelis, Marilyn
AU - Kutalik, Zoltan
AU - Lim, Elise
AU - Luan, Jian’an
AU - Huffman, Jennifer E.
AU - Zhang, Weihua
AU - Zhao, Wei
AU - Griffin, Paula J.
AU - Haller, Toomas
AU - Ahmad, Shafqat
AU - Marques-Vidal, Pedro M.
AU - Bien, Stephanie
AU - Yengo, Loic
AU - Teumer, Alexander
AU - Smith, Albert Vernon
AU - Kumari, Meena
AU - Harder, Marie Neergaard
AU - Justesen, Johanne Marie
AU - Kleber, Marcus E.
AU - Hollensted, Mette
AU - Lohman, Kurt
AU - Rivera, Natalia V.
AU - Whitfield, John B.
AU - Zhao, Jing Hua
AU - Stringham, Heather M.
AU - Lyytikäinen, Leo Pekka
AU - Huppertz, Charlotte
AU - Willemsen, Gonneke
AU - Hottenga, Jouke Jan
N1 - Publisher Copyright:
© 2017 Public Library of Science.All rights reserved.
PY - 2017/4
Y1 - 2017/4
N2 - Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by ~30% in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery.
AB - Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by ~30% in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery.
UR - https://www.scopus.com/pages/publications/85018450983
U2 - 10.1371/journal.pgen.1006528
DO - 10.1371/journal.pgen.1006528
M3 - Article
C2 - 28448500
SN - 1553-7390
VL - 13
JO - PLoS Genetics
JF - PLoS Genetics
IS - 4
M1 - e1006528
ER -