Genome-wide meta-analysis identifies new susceptibility loci for migraine

Verneri Anttila; Bendik S. Winsvold; Padhraig Gormley; Tobias Kurth; Francesco Bettella; George McMahon; Mikko Kallela; Rainer Malik; Boukje De Vries; Gisela Terwindt; Sarah E. Medland; Unda Todt; Wendy L. McArdle; Lydia Quaye; Markku Koiranen; Marfan Ikram; Terho Lehtimäki; Anine H. Stam; Lannie Ligthart; Juho Wedenoja; Ian Dunham; Benjamin M. Neale; Priit Palta; Eija Hamalainen; Markus Schürks; Lynda M. Rose; Julie E. Buring; Paul M. Ridker; Stacy Steinberg; Hreinn Stefansson; Finnbogi Jakobsson; Debbie A. Lawlor; David M. Evans; Susan M. Ring; Markus Färkkilä; Ville Artto; Mari A. Kaunisto; Tobias Freilinger; Jean Schoenen; Rune R. Frants; Nadine Pelzer; Claudia M. Weller; Ronald Zielman; Andrew C. Heath; Pamela A.F. Madden; Grant W. Montgomery; Nicholas G. Martin; Guntram Borck; Hartmut Göbel; Axel Heinze; Katja Heinze Kuhn; Frances M.K. Williams; Anna Liisa Hartikainen; Anneli Pouta; Joyce Van Den Ende; Andre G. Uitterlinden; Albert Hofman; Najaf Amin; Jouke Jan Hottenga; Jacqueline M. Vink; Kauko Heikkilä; Michael Alexander; Bertram Muller Myhsok; Stefan Schreiber; Thomas Meitinger; Heinz Erich Wichmann; Arpo Aromaa; Johan G. Eriksson; Bryan J. Traynor; Daniah Trabzuni; Elizabeth Rossin; Kasper Lage; Suzanne B.R. Jacobs; J. Raphael Gibbs; Ewan Birney; Jaakko Kaprio; Brenda W. Penninx; Dorret I. Boomsma; Cornelia Van Duijn; Olli Raitakari; Marjo Riitta Jarvelin; John Anker Zwart; Lynn Cherkas; David P. Strachan; Christian Kubisch; Michel D. Ferrari; Arn Mjm J.M. Van Den Maagdenberg; Martin Dichgans; Maija Wessman; George Davey Smith; Kari Stefansson; Mark J. Daly; Dale R. Nyholt; Daniel I. Chasman; Aarno Palotie

doi:10.1038/ng.2676

Genome-wide meta-analysis identifies new susceptibility loci for migraine

Verneri Anttila
, Bendik S. Winsvold
, Padhraig Gormley
, Tobias Kurth
, Francesco Bettella
, George McMahon
, Mikko Kallela
, Rainer Malik
, Boukje De Vries
, Gisela Terwindt
, Sarah E. Medland
, Unda Todt
, Wendy L. McArdle
, Lydia Quaye
, Markku Koiranen
, Marfan Ikram
, Terho Lehtimäki
, Anine H. Stam
, Lannie Ligthart
, Juho Wedenoja

Ian Dunham, Benjamin M. Neale, Priit Palta, Eija Hamalainen, Markus Schürks, Lynda M. Rose, Julie E. Buring, Paul M. Ridker, Stacy Steinberg, Hreinn Stefansson, Finnbogi Jakobsson, Debbie A. Lawlor, David M. Evans, Susan M. Ring, Markus Färkkilä, Ville Artto, Mari A. Kaunisto, Tobias Freilinger, Jean Schoenen, Rune R. Frants, Nadine Pelzer, Claudia M. Weller, Ronald Zielman, Andrew C. Heath, Pamela A.F. Madden, Grant W. Montgomery, Nicholas G. Martin, Guntram Borck, Hartmut Göbel, Axel Heinze, Katja Heinze Kuhn, Frances M.K. Williams, Anna Liisa Hartikainen, Anneli Pouta, Joyce Van Den Ende, Andre G. Uitterlinden, Albert Hofman, Najaf Amin, Jouke Jan Hottenga, Jacqueline M. Vink, Kauko Heikkilä, Michael Alexander, Bertram Muller Myhsok, Stefan Schreiber, Thomas Meitinger, Heinz Erich Wichmann, Arpo Aromaa, Johan G. Eriksson, Bryan J. Traynor, Daniah Trabzuni, Elizabeth Rossin, Kasper Lage, Suzanne B.R. Jacobs, J. Raphael Gibbs, Ewan Birney, Jaakko Kaprio, Brenda W. Penninx, Dorret I. Boomsma, Cornelia Van Duijn, Olli Raitakari, Marjo Riitta Jarvelin, John Anker Zwart, Lynn Cherkas, David P. Strachan, Christian Kubisch, Michel D. Ferrari, Arn Mjm J.M. Van Den Maagdenberg, Martin Dichgans, Maija Wessman, George Davey Smith, Kari Stefansson, Mark J. Daly, Dale R. Nyholt, Daniel I. Chasman, Aarno Palotie^*

^*Corresponding author for this work

Wellcome Trust Sanger Institute
University of Helsinki
Massachusetts General Hospital
Broad Institute
University of Oslo
Institut national de la santé et de la recherche médicale
Université de Bordeaux
Brigham and Women’s Hospital
deCODE Genetics
University of Bristol
Helsinki University Hospital
Ludwig Maximilian University of Munich
Leiden University
Queensland Institute of Medical Research
Ulm University
King's College London
University of Oulu
Erasmus University Rotterdam
Tampere University
Vrije Universiteit Amsterdam
VU University Medical Center
Wellcome Trust
University of Duisburg-Essen
Harvard University
Landspitali University Hospital
Folkhalsan
University of Liege
Washington University St. Louis
Kiel Pain and Headache Center
National Institute for Health and Welfare
University of Bonn
Max Planck Institute of Psychiatry
Munich Cluster for Systems Neurology (SyNergy)
Kiel University
Helmholtz Zentrum München - German Research Center for Environmental Health
Technical University of Munich
Vaasa Hospital District
National Institutes of Health
University College London
King Faisal Specialist Hospital and Research Centre
Technical University of Denmark
University of Copenhagen
University of Groningen
University of Turku
UK Health Security Agency
St. George's University of London
University of Iceland

Research output: Contribution to journal › Article › peer-review

348 Citations (Scopus)

Abstract

Migraine is the most common brain disorder, affecting approximately 14% of the adult population, but its molecular mechanisms are poorly understood. We report the results of a meta-analysis across 29 genome-wide association studies, including a total of 23,285 individuals with migraine (cases) and 95,425 population-matched controls. We identified 12 loci associated with migraine susceptibility (P < 5 × 10^-8). Five loci are new: near AJAP1 at 1p36, near TSPAN2 at 1p13, within FHL5 at 6q16, within C7orf10 at 7p14 and near MMP16 at 8q21. Three of these loci were identified in disease subgroup analyses. Brain tissue expression quantitative trait locus analysis suggests potential functional candidate genes at four loci: APOA1BP, TBC1D7, FUT9, STAT6 and ATP5B.

Original language	English
Pages (from-to)	912-917
Number of pages	6
Journal	Nature Genetics
Volume	45
Issue number	8
DOIs	https://doi.org/10.1038/ng.2676
Publication status	Published - Aug 2013
Externally published	Yes

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10.1038/ng.2676

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Anttila, V., Winsvold, B. S., Gormley, P., Kurth, T., Bettella, F., McMahon, G., Kallela, M., Malik, R., De Vries, B., Terwindt, G., Medland, S. E., Todt, U., McArdle, W. L., Quaye, L., Koiranen, M., Ikram, M., Lehtimäki, T., Stam, A. H., Ligthart, L., ... Palotie, A. (2013). Genome-wide meta-analysis identifies new susceptibility loci for migraine. Nature Genetics, 45(8), 912-917. https://doi.org/10.1038/ng.2676

@article{87b6633dfbde48789d066b682039ea36,

title = "Genome-wide meta-analysis identifies new susceptibility loci for migraine",

abstract = "Migraine is the most common brain disorder, affecting approximately 14\% of the adult population, but its molecular mechanisms are poorly understood. We report the results of a meta-analysis across 29 genome-wide association studies, including a total of 23,285 individuals with migraine (cases) and 95,425 population-matched controls. We identified 12 loci associated with migraine susceptibility (P < 5 × 10-8). Five loci are new: near AJAP1 at 1p36, near TSPAN2 at 1p13, within FHL5 at 6q16, within C7orf10 at 7p14 and near MMP16 at 8q21. Three of these loci were identified in disease subgroup analyses. Brain tissue expression quantitative trait locus analysis suggests potential functional candidate genes at four loci: APOA1BP, TBC1D7, FUT9, STAT6 and ATP5B.",

author = "Verneri Anttila and Winsvold, \{Bendik S.\} and Padhraig Gormley and Tobias Kurth and Francesco Bettella and George McMahon and Mikko Kallela and Rainer Malik and \{De Vries\}, Boukje and Gisela Terwindt and Medland, \{Sarah E.\} and Unda Todt and McArdle, \{Wendy L.\} and Lydia Quaye and Markku Koiranen and Marfan Ikram and Terho Lehtim{\"a}ki and Stam, \{Anine H.\} and Lannie Ligthart and Juho Wedenoja and Ian Dunham and Neale, \{Benjamin M.\} and Priit Palta and Eija Hamalainen and Markus Sch{\"u}rks and Rose, \{Lynda M.\} and Buring, \{Julie E.\} and Ridker, \{Paul M.\} and Stacy Steinberg and Hreinn Stefansson and Finnbogi Jakobsson and Lawlor, \{Debbie A.\} and Evans, \{David M.\} and Ring, \{Susan M.\} and Markus F{\"a}rkkil{\"a} and Ville Artto and Kaunisto, \{Mari A.\} and Tobias Freilinger and Jean Schoenen and Frants, \{Rune R.\} and Nadine Pelzer and Weller, \{Claudia M.\} and Ronald Zielman and Heath, \{Andrew C.\} and Madden, \{Pamela A.F.\} and Montgomery, \{Grant W.\} and Martin, \{Nicholas G.\} and Guntram Borck and Hartmut G{\"o}bel and Axel Heinze and Kuhn, \{Katja Heinze\} and Williams, \{Frances M.K.\} and Hartikainen, \{Anna Liisa\} and Anneli Pouta and \{Van Den Ende\}, Joyce and Uitterlinden, \{Andre G.\} and Albert Hofman and Najaf Amin and Hottenga, \{Jouke Jan\} and Vink, \{Jacqueline M.\} and Kauko Heikkil{\"a} and Michael Alexander and Myhsok, \{Bertram Muller\} and Stefan Schreiber and Thomas Meitinger and Wichmann, \{Heinz Erich\} and Arpo Aromaa and Eriksson, \{Johan G.\} and Traynor, \{Bryan J.\} and Daniah Trabzuni and Elizabeth Rossin and Kasper Lage and Jacobs, \{Suzanne B.R.\} and Gibbs, \{J. Raphael\} and Ewan Birney and Jaakko Kaprio and Penninx, \{Brenda W.\} and Boomsma, \{Dorret I.\} and \{Van Duijn\}, Cornelia and Olli Raitakari and Jarvelin, \{Marjo Riitta\} and Zwart, \{John Anker\} and Lynn Cherkas and Strachan, \{David P.\} and Christian Kubisch and Ferrari, \{Michel D.\} and \{Van Den Maagdenberg\}, \{Arn Mjm J.M.\} and Martin Dichgans and Maija Wessman and Smith, \{George Davey\} and Kari Stefansson and Daly, \{Mark J.\} and Nyholt, \{Dale R.\} and Chasman, \{Daniel I.\} and Aarno Palotie",

year = "2013",

month = aug,

doi = "10.1038/ng.2676",

language = "English",

volume = "45",

pages = "912--917",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Research",

number = "8",

}

Anttila, V, Winsvold, BS, Gormley, P, Kurth, T, Bettella, F, McMahon, G, Kallela, M, Malik, R, De Vries, B, Terwindt, G, Medland, SE, Todt, U, McArdle, WL, Quaye, L, Koiranen, M, Ikram, M, Lehtimäki, T, Stam, AH, Ligthart, L, Wedenoja, J, Dunham, I, Neale, BM, Palta, P, Hamalainen, E, Schürks, M, Rose, LM, Buring, JE, Ridker, PM, Steinberg, S, Stefansson, H, Jakobsson, F, Lawlor, DA, Evans, DM, Ring, SM, Färkkilä, M, Artto, V, Kaunisto, MA, Freilinger, T, Schoenen, J, Frants, RR, Pelzer, N, Weller, CM, Zielman, R, Heath, AC, Madden, PAF, Montgomery, GW, Martin, NG, Borck, G, Göbel, H, Heinze, A, Kuhn, KH, Williams, FMK, Hartikainen, AL, Pouta, A, Van Den Ende, J, Uitterlinden, AG, Hofman, A, Amin, N, Hottenga, JJ, Vink, JM, Heikkilä, K, Alexander, M, Myhsok, BM, Schreiber, S, Meitinger, T, Wichmann, HE, Aromaa, A, Eriksson, JG, Traynor, BJ, Trabzuni, D, Rossin, E, Lage, K, Jacobs, SBR, Gibbs, JR, Birney, E, Kaprio, J, Penninx, BW, Boomsma, DI, Van Duijn, C, Raitakari, O, Jarvelin, MR, Zwart, JA, Cherkas, L, Strachan, DP, Kubisch, C, Ferrari, MD, Van Den Maagdenberg, AMJM, Dichgans, M, Wessman, M, Smith, GD, Stefansson, K, Daly, MJ, Nyholt, DR, Chasman, DI & Palotie, A 2013, 'Genome-wide meta-analysis identifies new susceptibility loci for migraine', Nature Genetics, vol. 45, no. 8, pp. 912-917. https://doi.org/10.1038/ng.2676

TY - JOUR

T1 - Genome-wide meta-analysis identifies new susceptibility loci for migraine

AU - Anttila, Verneri

AU - Winsvold, Bendik S.

AU - Gormley, Padhraig

AU - Kurth, Tobias

AU - Bettella, Francesco

AU - McMahon, George

AU - Kallela, Mikko

AU - Malik, Rainer

AU - De Vries, Boukje

AU - Terwindt, Gisela

AU - Medland, Sarah E.

AU - Todt, Unda

AU - McArdle, Wendy L.

AU - Quaye, Lydia

AU - Koiranen, Markku

AU - Ikram, Marfan

AU - Lehtimäki, Terho

AU - Stam, Anine H.

AU - Ligthart, Lannie

AU - Wedenoja, Juho

AU - Dunham, Ian

AU - Neale, Benjamin M.

AU - Palta, Priit

AU - Hamalainen, Eija

AU - Schürks, Markus

AU - Rose, Lynda M.

AU - Buring, Julie E.

AU - Ridker, Paul M.

AU - Steinberg, Stacy

AU - Stefansson, Hreinn

AU - Jakobsson, Finnbogi

AU - Lawlor, Debbie A.

AU - Evans, David M.

AU - Ring, Susan M.

AU - Färkkilä, Markus

AU - Artto, Ville

AU - Kaunisto, Mari A.

AU - Freilinger, Tobias

AU - Schoenen, Jean

AU - Frants, Rune R.

AU - Pelzer, Nadine

AU - Weller, Claudia M.

AU - Zielman, Ronald

AU - Heath, Andrew C.

AU - Madden, Pamela A.F.

AU - Montgomery, Grant W.

AU - Martin, Nicholas G.

AU - Borck, Guntram

AU - Göbel, Hartmut

AU - Heinze, Axel

AU - Kuhn, Katja Heinze

AU - Williams, Frances M.K.

AU - Hartikainen, Anna Liisa

AU - Pouta, Anneli

AU - Van Den Ende, Joyce

AU - Uitterlinden, Andre G.

AU - Hofman, Albert

AU - Amin, Najaf

AU - Hottenga, Jouke Jan

AU - Vink, Jacqueline M.

AU - Heikkilä, Kauko

AU - Alexander, Michael

AU - Myhsok, Bertram Muller

AU - Schreiber, Stefan

AU - Meitinger, Thomas

AU - Wichmann, Heinz Erich

AU - Aromaa, Arpo

AU - Eriksson, Johan G.

AU - Traynor, Bryan J.

AU - Trabzuni, Daniah

AU - Rossin, Elizabeth

AU - Lage, Kasper

AU - Jacobs, Suzanne B.R.

AU - Gibbs, J. Raphael

AU - Birney, Ewan

AU - Kaprio, Jaakko

AU - Penninx, Brenda W.

AU - Boomsma, Dorret I.

AU - Van Duijn, Cornelia

AU - Raitakari, Olli

AU - Jarvelin, Marjo Riitta

AU - Zwart, John Anker

AU - Cherkas, Lynn

AU - Strachan, David P.

AU - Kubisch, Christian

AU - Ferrari, Michel D.

AU - Van Den Maagdenberg, Arn Mjm J.M.

AU - Dichgans, Martin

AU - Wessman, Maija

AU - Smith, George Davey

AU - Stefansson, Kari

AU - Daly, Mark J.

AU - Nyholt, Dale R.

AU - Chasman, Daniel I.

AU - Palotie, Aarno

PY - 2013/8

Y1 - 2013/8

N2 - Migraine is the most common brain disorder, affecting approximately 14% of the adult population, but its molecular mechanisms are poorly understood. We report the results of a meta-analysis across 29 genome-wide association studies, including a total of 23,285 individuals with migraine (cases) and 95,425 population-matched controls. We identified 12 loci associated with migraine susceptibility (P < 5 × 10-8). Five loci are new: near AJAP1 at 1p36, near TSPAN2 at 1p13, within FHL5 at 6q16, within C7orf10 at 7p14 and near MMP16 at 8q21. Three of these loci were identified in disease subgroup analyses. Brain tissue expression quantitative trait locus analysis suggests potential functional candidate genes at four loci: APOA1BP, TBC1D7, FUT9, STAT6 and ATP5B.

AB - Migraine is the most common brain disorder, affecting approximately 14% of the adult population, but its molecular mechanisms are poorly understood. We report the results of a meta-analysis across 29 genome-wide association studies, including a total of 23,285 individuals with migraine (cases) and 95,425 population-matched controls. We identified 12 loci associated with migraine susceptibility (P < 5 × 10-8). Five loci are new: near AJAP1 at 1p36, near TSPAN2 at 1p13, within FHL5 at 6q16, within C7orf10 at 7p14 and near MMP16 at 8q21. Three of these loci were identified in disease subgroup analyses. Brain tissue expression quantitative trait locus analysis suggests potential functional candidate genes at four loci: APOA1BP, TBC1D7, FUT9, STAT6 and ATP5B.

UR - https://www.scopus.com/pages/publications/84881022482

U2 - 10.1038/ng.2676

DO - 10.1038/ng.2676

M3 - Article

C2 - 23793025

AN - SCOPUS:84881022482

SN - 1061-4036

VL - 45

SP - 912

EP - 917

JO - Nature Genetics

JF - Nature Genetics

IS - 8

ER -

Genome-wide meta-analysis identifies new susceptibility loci for migraine

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