Genome-wide Association Study of Smoking Initiation and Current Smoking

Jacqueline M. Vink; August B. Smit; Eco J.C. de Geus; Patrick Sullivan; Gonneke Willemsen; Jouke Jan Hottenga; Johannes H. Smit; Witte J. Hoogendijk; Frans G. Zitman; Leena Peltonen; Jaakko Kaprio; Nancy L. Pedersen; Patrik K. Magnusson; Tim D. Spector; Kirsten Ohm Kyvik; Katherine I. Morley; Andrew C. Heath; Nicholas G. Martin; Rudi G.J. Westendorp; P. Eline Slagboom; Henning Tiemeier; Albert Hofman; Andre G. Uitterlinden; Yurii S. Aulchenko; Najaf Amin; Cornelia van Duijn; Brenda W. Penninx; Dorret I. Boomsma

doi:10.1016/j.ajhg.2009.02.001

Genome-wide Association Study of Smoking Initiation and Current Smoking

Jacqueline M. Vink^*
, August B. Smit
, Eco J.C. de Geus
, Patrick Sullivan
, Gonneke Willemsen
, Jouke Jan Hottenga
, Johannes H. Smit
, Witte J. Hoogendijk
, Frans G. Zitman
, Leena Peltonen
, Jaakko Kaprio
, Nancy L. Pedersen
, Patrik K. Magnusson
, Tim D. Spector
, Kirsten Ohm Kyvik
, Katherine I. Morley
, Andrew C. Heath
, Nicholas G. Martin
, Rudi G.J. Westendorp
, P. Eline Slagboom

Henning Tiemeier, Albert Hofman, Andre G. Uitterlinden, Yurii S. Aulchenko, Najaf Amin, Cornelia van Duijn, Brenda W. Penninx, Dorret I. Boomsma

^*Corresponding author for this work

Vrije Universiteit Amsterdam
University of North Carolina at Chapel Hill
University of Amsterdam
Leiden University
National Institute for Health and Welfare
University of Helsinki
Massachusetts Institute of Technology
Wellcome Trust Sanger Institute
Karolinska Institutet
King's College London
University of Southern Denmark
University of Melbourne
Queensland Institute of Medical Research
Washington University St. Louis
Erasmus University Rotterdam
University of Groningen

Research output: Contribution to journal › Article › peer-review

117 Citations (Scopus)

Abstract

For the identification of genes associated with smoking initiation and current smoking, genome-wide association analyses were carried out in 3497 subjects. Significant genes that replicated in three independent samples (n = 405, 5810, and 1648) were visualized into a biologically meaningful network showing cellular location and direct interaction of their proteins. Several interesting groups of proteins stood out, including glutamate receptors (e.g., GRIN2B, GRIN2A, GRIK2, GRM8), proteins involved in tyrosine kinase receptor signaling (e.g., NTRK2, GRB14), transporters (e.g., SLC1A2, SLC9A9) and cell-adhesion molecules (e.g., CDH23). We conclude that a network-based genome-wide association approach can identify genes influencing smoking behavior.

Original language	English
Pages (from-to)	367-379
Number of pages	13
Journal	American Journal of Human Genetics
Volume	84
Issue number	3
DOIs	https://doi.org/10.1016/j.ajhg.2009.02.001
Publication status	Published - 13 Mar 2009
Externally published	Yes

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Vink, J. M., Smit, A. B., de Geus, E. J. C., Sullivan, P., Willemsen, G., Hottenga, J. J., Smit, J. H., Hoogendijk, W. J., Zitman, F. G., Peltonen, L., Kaprio, J., Pedersen, N. L., Magnusson, P. K., Spector, T. D., Kyvik, K. O., Morley, K. I., Heath, A. C., Martin, N. G., Westendorp, R. G. J., ... Boomsma, D. I. (2009). Genome-wide Association Study of Smoking Initiation and Current Smoking. American Journal of Human Genetics, 84(3), 367-379. https://doi.org/10.1016/j.ajhg.2009.02.001

@article{68542fcd9e094b678e64b0911efe7308,

title = "Genome-wide Association Study of Smoking Initiation and Current Smoking",

abstract = "For the identification of genes associated with smoking initiation and current smoking, genome-wide association analyses were carried out in 3497 subjects. Significant genes that replicated in three independent samples (n = 405, 5810, and 1648) were visualized into a biologically meaningful network showing cellular location and direct interaction of their proteins. Several interesting groups of proteins stood out, including glutamate receptors (e.g., GRIN2B, GRIN2A, GRIK2, GRM8), proteins involved in tyrosine kinase receptor signaling (e.g., NTRK2, GRB14), transporters (e.g., SLC1A2, SLC9A9) and cell-adhesion molecules (e.g., CDH23). We conclude that a network-based genome-wide association approach can identify genes influencing smoking behavior.",

author = "Vink, \{Jacqueline M.\} and Smit, \{August B.\} and \{de Geus\}, \{Eco J.C.\} and Patrick Sullivan and Gonneke Willemsen and Hottenga, \{Jouke Jan\} and Smit, \{Johannes H.\} and Hoogendijk, \{Witte J.\} and Zitman, \{Frans G.\} and Leena Peltonen and Jaakko Kaprio and Pedersen, \{Nancy L.\} and Magnusson, \{Patrik K.\} and Spector, \{Tim D.\} and Kyvik, \{Kirsten Ohm\} and Morley, \{Katherine I.\} and Heath, \{Andrew C.\} and Martin, \{Nicholas G.\} and Westendorp, \{Rudi G.J.\} and Slagboom, \{P. Eline\} and Henning Tiemeier and Albert Hofman and Uitterlinden, \{Andre G.\} and Aulchenko, \{Yurii S.\} and Najaf Amin and \{van Duijn\}, Cornelia and Penninx, \{Brenda W.\} and Boomsma, \{Dorret I.\}",

year = "2009",

month = mar,

day = "13",

doi = "10.1016/j.ajhg.2009.02.001",

language = "English",

volume = "84",

pages = "367--379",

journal = "American Journal of Human Genetics",

issn = "0002-9297",

publisher = "Cell Press",

number = "3",

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Vink, JM, Smit, AB, de Geus, EJC, Sullivan, P, Willemsen, G, Hottenga, JJ, Smit, JH, Hoogendijk, WJ, Zitman, FG, Peltonen, L, Kaprio, J, Pedersen, NL, Magnusson, PK, Spector, TD, Kyvik, KO, Morley, KI, Heath, AC, Martin, NG, Westendorp, RGJ, Slagboom, PE, Tiemeier, H, Hofman, A, Uitterlinden, AG, Aulchenko, YS, Amin, N, van Duijn, C, Penninx, BW & Boomsma, DI 2009, 'Genome-wide Association Study of Smoking Initiation and Current Smoking', American Journal of Human Genetics, vol. 84, no. 3, pp. 367-379. https://doi.org/10.1016/j.ajhg.2009.02.001

TY - JOUR

T1 - Genome-wide Association Study of Smoking Initiation and Current Smoking

AU - Vink, Jacqueline M.

AU - Smit, August B.

AU - de Geus, Eco J.C.

AU - Sullivan, Patrick

AU - Willemsen, Gonneke

AU - Hottenga, Jouke Jan

AU - Smit, Johannes H.

AU - Hoogendijk, Witte J.

AU - Zitman, Frans G.

AU - Peltonen, Leena

AU - Kaprio, Jaakko

AU - Pedersen, Nancy L.

AU - Magnusson, Patrik K.

AU - Spector, Tim D.

AU - Kyvik, Kirsten Ohm

AU - Morley, Katherine I.

AU - Heath, Andrew C.

AU - Martin, Nicholas G.

AU - Westendorp, Rudi G.J.

AU - Slagboom, P. Eline

AU - Tiemeier, Henning

AU - Hofman, Albert

AU - Uitterlinden, Andre G.

AU - Aulchenko, Yurii S.

AU - Amin, Najaf

AU - van Duijn, Cornelia

AU - Penninx, Brenda W.

AU - Boomsma, Dorret I.

PY - 2009/3/13

Y1 - 2009/3/13

N2 - For the identification of genes associated with smoking initiation and current smoking, genome-wide association analyses were carried out in 3497 subjects. Significant genes that replicated in three independent samples (n = 405, 5810, and 1648) were visualized into a biologically meaningful network showing cellular location and direct interaction of their proteins. Several interesting groups of proteins stood out, including glutamate receptors (e.g., GRIN2B, GRIN2A, GRIK2, GRM8), proteins involved in tyrosine kinase receptor signaling (e.g., NTRK2, GRB14), transporters (e.g., SLC1A2, SLC9A9) and cell-adhesion molecules (e.g., CDH23). We conclude that a network-based genome-wide association approach can identify genes influencing smoking behavior.

AB - For the identification of genes associated with smoking initiation and current smoking, genome-wide association analyses were carried out in 3497 subjects. Significant genes that replicated in three independent samples (n = 405, 5810, and 1648) were visualized into a biologically meaningful network showing cellular location and direct interaction of their proteins. Several interesting groups of proteins stood out, including glutamate receptors (e.g., GRIN2B, GRIN2A, GRIK2, GRM8), proteins involved in tyrosine kinase receptor signaling (e.g., NTRK2, GRB14), transporters (e.g., SLC1A2, SLC9A9) and cell-adhesion molecules (e.g., CDH23). We conclude that a network-based genome-wide association approach can identify genes influencing smoking behavior.

UR - https://www.scopus.com/pages/publications/61849154183

U2 - 10.1016/j.ajhg.2009.02.001

DO - 10.1016/j.ajhg.2009.02.001

M3 - Article

C2 - 19268276

AN - SCOPUS:61849154183

SN - 0002-9297

VL - 84

SP - 367

EP - 379

JO - American Journal of Human Genetics

JF - American Journal of Human Genetics

IS - 3

ER -

Genome-wide Association Study of Smoking Initiation and Current Smoking

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