TY - JOUR
T1 - Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk
AU - The International Genomics of Blood Pressure (iGEN -BP) Consortium
AU - for The UK Biobank CardioMetabolic Consortium BP working group Louise
AU - BIOS Consortium
AU - Lifelines Cohort Study
AU - Understanding Society Scientific group
AU - The International Consortium of Blood Pressure (ICBP) 1000G Analyses
AU - The CHD Exome+ Consortium
AU - The ExomeBP Consortium
AU - The T2D-GENES Consortium
AU - The GoT2DGenes Consortium
AU - The Cohorts for Heart and Ageing Research in Genome Epidemiology (CHARGE) BP Exome Consortium
AU - Warren, Helen R.
AU - Evangelou, Evangelos
AU - Cabrera, Claudia P.
AU - Gao, He
AU - Ren, Meixia
AU - Mifsud, Borbala
AU - Ntalla, Ioanna
AU - Surendran, Praveen
AU - Liu, Chunyu
AU - Cook, James P.
AU - Kraja, Aldi T.
AU - Drenos, Fotios
AU - Loh, Marie
AU - Verweij, Niek
AU - Marten, Jonathan
AU - Karaman, Ibrahim
AU - Segura Lepe, Marcelo P.
AU - O'Reilly, Paul F.
AU - Knight, Joanne
AU - Snieder, Harold
AU - Kato, Norihiro
AU - He, Jiang
AU - Shyong Tai, E.
AU - Abdullah Said, M.
AU - Porteous, David
AU - Alver, Maris
AU - Poulter, Neil
AU - Farrall, Martin
AU - Gansevoort, Ron T.
AU - Padmanabhan, Sandosh
AU - Mägi, Reedik
AU - Stanton, Alice
AU - Connell, John
AU - Bakker, Stephan J.L.
AU - Metspalu, Andres
AU - Shields, Denis C.
AU - Thom, Simon
AU - Brown, Morris
AU - Sever, Peter
AU - Esko, Tõnu
AU - Hayward, Caroline
AU - van der Harst, Pim
AU - Saleheen, Danish
AU - Chowdhury, Rajiv
AU - Chambers, John C.
AU - Chasman, Daniel I.
AU - Chakravarti, Aravinda
AU - Newton-Cheh, Christopher
AU - Lindgren, Cecilia M.
AU - Hottenga, Jouke Jan
PY - 2017/3/1
Y1 - 2017/3/1
N2 - Elevated blood pressure is the leading heritable risk factor for cardiovascular disease worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pressure) among UK Biobank participants of European ancestry with independent replication in other cohorts, and robust validation of 107 independent loci. We also identify new independent variants at 11 previously reported blood pressure loci. In combination with results from a range of in silico functional analyses and wet bench experiments, our findings highlight new biological pathways for blood pressure regulation enriched for genes expressed in vascular tissues and identify potential therapeutic targets for hypertension. Results from genetic risk score models raise the possibility of a precision medicine approach through early lifestyle intervention to offset the impact of blood pressure-raising genetic variants on future cardiovascular disease risk.
AB - Elevated blood pressure is the leading heritable risk factor for cardiovascular disease worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pressure) among UK Biobank participants of European ancestry with independent replication in other cohorts, and robust validation of 107 independent loci. We also identify new independent variants at 11 previously reported blood pressure loci. In combination with results from a range of in silico functional analyses and wet bench experiments, our findings highlight new biological pathways for blood pressure regulation enriched for genes expressed in vascular tissues and identify potential therapeutic targets for hypertension. Results from genetic risk score models raise the possibility of a precision medicine approach through early lifestyle intervention to offset the impact of blood pressure-raising genetic variants on future cardiovascular disease risk.
UR - https://www.scopus.com/pages/publications/85010952930
U2 - 10.1038/ng.3768
DO - 10.1038/ng.3768
M3 - Article
C2 - 28135244
AN - SCOPUS:85010952930
SN - 1061-4036
VL - 49
SP - 403
EP - 415
JO - Nature Genetics
JF - Nature Genetics
IS - 3
ER -