TY - JOUR
T1 - Genetic influences on schizophrenia and subcortical brain volumes
T2 - Large-scale proof of concept
AU - Psychosis Endophenotypes International Consortium
AU - Franke, Barbara
AU - van Hulzen, Kimm J.E.
AU - Arias-Vasquez, Alejandro
AU - Bralten, Janita
AU - Hoogman, Martine
AU - Klein, Marieke
AU - van Donkelaar, Marjolein M.J.
AU - Hakobjan, Marina M.H.
AU - Heister, Angelien J.G.A.M.
AU - Makkinje, Remco R.R.
AU - Naber, Marlies A.M.
AU - van der Marel, Saskia S.L.
AU - Mostert, Jeanette C.
AU - Brunner, Han G.
AU - van Bokhoven, Hans
AU - Zwiers, Marcel P.
AU - Buitelaar, Jan K.
AU - Fernández, Guillén
AU - Fisher, Simon E.
AU - Francks, Clyde
AU - Stein, Jason L.
AU - Hibar, Derrek P.
AU - Thompson, Paul M.
AU - Ripke, Stephan
AU - Anttila, Verneri
AU - Neale, Benjamin M.
AU - Farh, Kai How
AU - Bulik-Sullivan, Brendan
AU - Huang, Hailiang
AU - Fromer, Menachem
AU - Goldstein, Jacqueline I.
AU - Daly, Mark J.
AU - Walters, Raymond K.
AU - Smoller, Jordan W.
AU - Lee, Phil
AU - Belliveau, Richard A.
AU - Bergen, Sarah E.
AU - Bevilacqua, Elizabeth
AU - Chambert, Kimberley D.
AU - Genovese, Giulio
AU - O'Dushlaine, Colm
AU - Scolnick, Edward M.
AU - McCarroll, Steven A.
AU - Moran, Jennifer L.
AU - Palotie, Aarno
AU - Petryshen, Tracey L.
AU - Erk, Susanne
AU - Heinz, Andreas
AU - Mohnke, Sebastian
AU - Hottenga, Jouke Jan
N1 - Publisher Copyright:
© 2016 Nature America, Inc. All rights reserved.
PY - 2016/2/23
Y1 - 2016/2/23
N2 - Schizophrenia is a devastating psychiatric illness with high heritability. Brain structure and function differ, on average, between people with schizophrenia and healthy individuals. As common genetic associations are emerging for both schizophrenia and brain imaging phenotypes, we can now use genome-wide data to investigate genetic overlap. Here we integrated results from common variant studies of schizophrenia (33,636 cases, 43,008 controls) and volumes of several (mainly subcortical) brain structures (11,840 subjects). We did not find evidence of genetic overlap between schizophrenia risk and subcortical volume measures either at the level of common variant genetic architecture or for single genetic markers. These results provide a proof of concept (albeit based on a limited set of structural brain measures) and define a roadmap for future studies investigating the genetic covariance between structural or functional brain phenotypes and risk for psychiatric disorders.
AB - Schizophrenia is a devastating psychiatric illness with high heritability. Brain structure and function differ, on average, between people with schizophrenia and healthy individuals. As common genetic associations are emerging for both schizophrenia and brain imaging phenotypes, we can now use genome-wide data to investigate genetic overlap. Here we integrated results from common variant studies of schizophrenia (33,636 cases, 43,008 controls) and volumes of several (mainly subcortical) brain structures (11,840 subjects). We did not find evidence of genetic overlap between schizophrenia risk and subcortical volume measures either at the level of common variant genetic architecture or for single genetic markers. These results provide a proof of concept (albeit based on a limited set of structural brain measures) and define a roadmap for future studies investigating the genetic covariance between structural or functional brain phenotypes and risk for psychiatric disorders.
UR - https://www.scopus.com/pages/publications/84959158225
U2 - 10.1038/nn.4228
DO - 10.1038/nn.4228
M3 - Article
C2 - 26854805
AN - SCOPUS:84959158225
SN - 1097-6256
VL - 19
SP - 420
EP - 431
JO - Nature Neuroscience
JF - Nature Neuroscience
IS - 3
ER -