Abstract
The contribution of genetic and environmental factors to the stability of obsessive-compulsive (OC) symptoms has not yet been established in adult population based samples. We obtained the Young Adult Self Report Obsessive-Compulsive Subscale in mono- and dizygotic twins from the population-based Netherlands Twin Register in 1991, 1995 and 1997 and the Padua Inventory Revised Abbreviated in 2002. Stability of OC symptoms was analyzed as a function of genetic and environmental components. Heritability of OC behavior was around 40% at each time-point, independent of the instrument used. OC behavior was moderately stable with correlations ranging between r = .2 (for 11-year intervals), .4 (for 4-5 year intervals) and .6 (for 2 year intervals). Genetic correlations across time were higher, varying between .4 and .9, indicating that the stability of OC symptoms is mainly due to stable genetic factors. This study showed a moderate heritability and stability for OC behavior in adults. Genetic stability across time is high.
| Original language | English |
|---|---|
| Pages (from-to) | 411-419 |
| Number of pages | 9 |
| Journal | Twin Research and Human Genetics |
| Volume | 12 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2009 |
| Externally published | Yes |
Keywords
- Longitudinal
- OC symptoms
- OCD
- Obsessive-compulsive disorder
- Twin study
- Twins
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