TY - JOUR
T1 - Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals
AU - 23andMe Research Team
AU - COGENT (Cognitive Genomics Consortium)
AU - Social Science Genetic Association Consortium
AU - Lee, James J.
AU - Wedow, Robbee
AU - Okbay, Aysu
AU - Kong, Edward
AU - Maghzian, Omeed
AU - Zacher, Meghan
AU - Nguyen-Viet, Tuan Anh
AU - Bowers, Peter
AU - Sidorenko, Julia
AU - Karlsson Linnér, Richard
AU - Fontana, Mark Alan
AU - Kundu, Tushar
AU - Lee, Chanwook
AU - Li, Hui
AU - Li, Ruoxi
AU - Royer, Rebecca
AU - Timshel, Pascal N.
AU - Walters, Raymond K.
AU - Willoughby, Emily A.
AU - Yengo, Loïc
AU - Agee, Michelle
AU - Alipanahi, Babak
AU - Auton, Adam
AU - Bell, Robert K.
AU - Bryc, Katarzyna
AU - Elson, Sarah L.
AU - Fontanillas, Pierre
AU - Hinds, David A.
AU - McCreight, Jennifer C.
AU - Huber, Karen E.
AU - Litterman, Nadia K.
AU - McIntyre, Matthew H.
AU - Mountain, Joanna L.
AU - Noblin, Elizabeth S.
AU - Northover, Carrie A.M.
AU - Pitts, Steven J.
AU - Sathirapongsasuti, J. Fah
AU - Sazonova, Olga V.
AU - Shelton, Janie F.
AU - Shringarpure, Suyash
AU - Tian, Chao
AU - Vacic, Vladimir
AU - Wilson, Catherine H.
AU - Beauchamp, Jonathan P.
AU - Pers, Tune H.
AU - Rietveld, Cornelius A.
AU - Turley, Patrick
AU - Chen, Guo Bo
AU - Emilsson, Valur
AU - Hottenga, Jouke Jan
N1 - Publisher Copyright:
© 2018, The Author(s).
PY - 2018/7/23
Y1 - 2018/7/23
N2 - Here we conducted a large-scale genetic association analysis of educational attainment in a sample of approximately 1.1 million individuals and identify 1,271 independent genome-wide-significant SNPs. For the SNPs taken together, we found evidence of heterogeneous effects across environments. The SNPs implicate genes involved in brain-development processes and neuron-to-neuron communication. In a separate analysis of the X chromosome, we identify 10 independent genome-wide-significant SNPs and estimate a SNP heritability of around 0.3% in both men and women, consistent with partial dosage compensation. A joint (multi-phenotype) analysis of educational attainment and three related cognitive phenotypes generates polygenic scores that explain 11–13% of the variance in educational attainment and 7–10% of the variance in cognitive performance. This prediction accuracy substantially increases the utility of polygenic scores as tools in research.
AB - Here we conducted a large-scale genetic association analysis of educational attainment in a sample of approximately 1.1 million individuals and identify 1,271 independent genome-wide-significant SNPs. For the SNPs taken together, we found evidence of heterogeneous effects across environments. The SNPs implicate genes involved in brain-development processes and neuron-to-neuron communication. In a separate analysis of the X chromosome, we identify 10 independent genome-wide-significant SNPs and estimate a SNP heritability of around 0.3% in both men and women, consistent with partial dosage compensation. A joint (multi-phenotype) analysis of educational attainment and three related cognitive phenotypes generates polygenic scores that explain 11–13% of the variance in educational attainment and 7–10% of the variance in cognitive performance. This prediction accuracy substantially increases the utility of polygenic scores as tools in research.
UR - https://www.scopus.com/pages/publications/85050543338
U2 - 10.1038/s41588-018-0147-3
DO - 10.1038/s41588-018-0147-3
M3 - Article
C2 - 30038396
AN - SCOPUS:85050543338
SN - 1061-4036
VL - 50
SP - 1112
EP - 1121
JO - Nature Genetics
JF - Nature Genetics
IS - 8
ER -