Evaluation of amino-substituted heterocyclic derivatives as alanine racemase inhibitors

Myoung Goo Kim; Ulrich Strych; Kurt Krause; Michael Benedik; Harold Kohn

Evaluation of amino-substituted heterocyclic derivatives as alanine racemase inhibitors

Myoung Goo Kim
, Ulrich Strych
, Kurt Krause
, Michael Benedik
, Harold Kohn^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

A series of five-membered (5-16) and six-membered (17-21) heterocyclic compounds were evaluated for inhibitory activity against purified alanine racemases (alr gene products) from E. coli, S. aureus, P. aeruginosa, and M. tuberculosis. Three compounds (5, 6, 11) were found to exhibit moderate inhibitory activity, in agreement with a recently proposed pathway for D-cycloserine (1) function.

Original language	English
Pages (from-to)	130-138
Number of pages	9
Journal	Medicinal Chemistry Research
Volume	12
Issue number	3
Publication status	Published - 2003
Externally published	Yes

Cite this

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title = "Evaluation of amino-substituted heterocyclic derivatives as alanine racemase inhibitors",

abstract = "A series of five-membered (5-16) and six-membered (17-21) heterocyclic compounds were evaluated for inhibitory activity against purified alanine racemases (alr gene products) from E. coli, S. aureus, P. aeruginosa, and M. tuberculosis. Three compounds (5, 6, 11) were found to exhibit moderate inhibitory activity, in agreement with a recently proposed pathway for D-cycloserine (1) function.",

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year = "2003",

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T1 - Evaluation of amino-substituted heterocyclic derivatives as alanine racemase inhibitors

AU - Kim, Myoung Goo

AU - Strych, Ulrich

AU - Krause, Kurt

AU - Benedik, Michael

AU - Kohn, Harold

PY - 2003

Y1 - 2003

N2 - A series of five-membered (5-16) and six-membered (17-21) heterocyclic compounds were evaluated for inhibitory activity against purified alanine racemases (alr gene products) from E. coli, S. aureus, P. aeruginosa, and M. tuberculosis. Three compounds (5, 6, 11) were found to exhibit moderate inhibitory activity, in agreement with a recently proposed pathway for D-cycloserine (1) function.

AB - A series of five-membered (5-16) and six-membered (17-21) heterocyclic compounds were evaluated for inhibitory activity against purified alanine racemases (alr gene products) from E. coli, S. aureus, P. aeruginosa, and M. tuberculosis. Three compounds (5, 6, 11) were found to exhibit moderate inhibitory activity, in agreement with a recently proposed pathway for D-cycloserine (1) function.

UR - https://www.scopus.com/pages/publications/0942301251

M3 - Article

AN - SCOPUS:0942301251

SN - 1054-2523

VL - 12

SP - 130

EP - 138

JO - Medicinal Chemistry Research

JF - Medicinal Chemistry Research

IS - 3

ER -

Evaluation of amino-substituted heterocyclic derivatives as alanine racemase inhibitors

Abstract

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