Efficient enantioselective synthesis of tetramic acids and lactams from threonine

Muhammad Anwar; Mark G. Moloney

doi:10.1016/j.tetlet.2007.08.052

Efficient enantioselective synthesis of tetramic acids and lactams from threonine

Muhammad Anwar
, Mark G. Moloney^*

^*Corresponding author for this work

University of Oxford

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

Regioselective Dieckmann and aldol cyclisations using an N-acyloxazolidine derived from threonine give substituted tetramic acids and pyroglutamates in high yield and enantioselectivity. These are easily deprotected under mild conditions to give products, some of which exhibit antibacterial activity.

Original language	English
Pages (from-to)	7259-7262
Number of pages	4
Journal	Tetrahedron Letters
Volume	48
Issue number	41
DOIs	https://doi.org/10.1016/j.tetlet.2007.08.052
Publication status	Published - 8 Oct 2007
Externally published	Yes

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10.1016/j.tetlet.2007.08.052

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title = "Efficient enantioselective synthesis of tetramic acids and lactams from threonine",

abstract = "Regioselective Dieckmann and aldol cyclisations using an N-acyloxazolidine derived from threonine give substituted tetramic acids and pyroglutamates in high yield and enantioselectivity. These are easily deprotected under mild conditions to give products, some of which exhibit antibacterial activity.",

author = "Muhammad Anwar and Moloney, \{Mark G.\}",

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AU - Anwar, Muhammad

AU - Moloney, Mark G.

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N2 - Regioselective Dieckmann and aldol cyclisations using an N-acyloxazolidine derived from threonine give substituted tetramic acids and pyroglutamates in high yield and enantioselectivity. These are easily deprotected under mild conditions to give products, some of which exhibit antibacterial activity.

AB - Regioselective Dieckmann and aldol cyclisations using an N-acyloxazolidine derived from threonine give substituted tetramic acids and pyroglutamates in high yield and enantioselectivity. These are easily deprotected under mild conditions to give products, some of which exhibit antibacterial activity.

UR - https://www.scopus.com/pages/publications/34548487491

U2 - 10.1016/j.tetlet.2007.08.052

DO - 10.1016/j.tetlet.2007.08.052

M3 - Article

AN - SCOPUS:34548487491

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SP - 7259

EP - 7262

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 41

ER -

Efficient enantioselective synthesis of tetramic acids and lactams from threonine

Abstract

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