Editorial Expression of Concern: Estrogen receptor β activation impairs mitochondrial oxidative metabolism and affects malignant mesothelioma cell growth in vitro and in vivo(Oncogenesis, (2026), 15, (29), 10.1038/s41389-026-00639-9)

A. G. Manente; D. Valenti; G. Pinton; P. V. Jithesh; A. Daga; L. Rossi; S. G. Gray; K. J. O’Byrne; D. A. Fennell; R. A. Vacca; S. Nilsson; L. Mutti; L. Moro

doi:10.1038/s41389-026-00639-9

Editorial Expression of Concern: Estrogen receptor β activation impairs mitochondrial oxidative metabolism and affects malignant mesothelioma cell growth in vitro and in vivo(Oncogenesis, (2026), 15, (29), 10.1038/s41389-026-00639-9)

A. G. Manente
, D. Valenti
, G. Pinton
, P. V. Jithesh
, A. Daga
, L. Rossi
, S. G. Gray
, K. J. O’Byrne
, D. A. Fennell
, R. A. Vacca
, S. Nilsson
, L. Mutti
, L. Moro^*

^*Corresponding author for this work

University of Eastern Piedmont
National Research Council of Italy
University of Liverpool
University Eye Clinic
University of Pisa
St James's Hospital
University of Leicester
Karo Bio
Karolinska Institutet
S. Andrea Hospital

Research output: Contribution to journal › Comment/debate

Abstract

The Editor-in-Chief would like to alert readers that concerns were raised regarding potential splicing between lanes 2 and 3 of ERβ/High ERβ panel of Figure 1b and between lanes 3 and 4 of the ERβ/cytosol panel of Figure 3a. The authors have stated that the data are no longer available due to the age of the study. Therefore, readers are advised to interpret the data listed above with caution. L Moro, S G Gray, R A Vacca, and G Pinton agree with this Editorial Expression of Concern. A G Manente, P V Jithesh, K J O’Byrne, D A Fennell, S Nilsson, and L Mutti did not reply to correspondence from the Publisher about this Editorial Expression of Concern. The Publisher was unable to contact D Valenti, A Daga, and L Rossi.

Original language	English
Article number	29
Journal	Oncogenesis
Volume	15
Issue number	1
DOIs	https://doi.org/10.1038/s41389-026-00639-9
Publication status	Published - Dec 2026
Externally published	Yes

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Manente, A. G., Valenti, D., Pinton, G., Jithesh, P. V., Daga, A., Rossi, L., Gray, S. G., O’Byrne, K. J., Fennell, D. A., Vacca, R. A., Nilsson, S., Mutti, L., & Moro, L. (2026). Editorial Expression of Concern: Estrogen receptor β activation impairs mitochondrial oxidative metabolism and affects malignant mesothelioma cell growth in vitro and in vivo(Oncogenesis, (2026), 15, (29), 10.1038/s41389-026-00639-9). Oncogenesis, 15(1), Article 29. https://doi.org/10.1038/s41389-026-00639-9

@article{b389832310a147eda6c4ee33001deb89,

title = "Editorial Expression of Concern: Estrogen receptor β activation impairs mitochondrial oxidative metabolism and affects malignant mesothelioma cell growth in vitro and in vivo(Oncogenesis, (2026), 15, (29), 10.1038/s41389-026-00639-9)",

abstract = "The Editor-in-Chief would like to alert readers that concerns were raised regarding potential splicing between lanes 2 and 3 of ERβ/High ERβ panel of Figure 1b and between lanes 3 and 4 of the ERβ/cytosol panel of Figure 3a. The authors have stated that the data are no longer available due to the age of the study. Therefore, readers are advised to interpret the data listed above with caution. L Moro, S G Gray, R A Vacca, and G Pinton agree with this Editorial Expression of Concern. A G Manente, P V Jithesh, K J O{\textquoteright}Byrne, D A Fennell, S Nilsson, and L Mutti did not reply to correspondence from the Publisher about this Editorial Expression of Concern. The Publisher was unable to contact D Valenti, A Daga, and L Rossi.",

author = "Manente, \{A. G.\} and D. Valenti and G. Pinton and Jithesh, \{P. V.\} and A. Daga and L. Rossi and Gray, \{S. G.\} and O{\textquoteright}Byrne, \{K. J.\} and Fennell, \{D. A.\} and Vacca, \{R. A.\} and S. Nilsson and L. Mutti and L. Moro",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2026.",

year = "2026",

month = dec,

doi = "10.1038/s41389-026-00639-9",

language = "English",

volume = "15",

journal = "Oncogenesis",

issn = "2157-9024",

publisher = "Springer Nature",

number = "1",

}

Manente, AG, Valenti, D, Pinton, G, Jithesh, PV, Daga, A, Rossi, L, Gray, SG, O’Byrne, KJ, Fennell, DA, Vacca, RA, Nilsson, S, Mutti, L & Moro, L 2026, 'Editorial Expression of Concern: Estrogen receptor β activation impairs mitochondrial oxidative metabolism and affects malignant mesothelioma cell growth in vitro and in vivo(Oncogenesis, (2026), 15, (29), 10.1038/s41389-026-00639-9)', Oncogenesis, vol. 15, no. 1, 29. https://doi.org/10.1038/s41389-026-00639-9

Editorial Expression of Concern: Estrogen receptor β activation impairs mitochondrial oxidative metabolism and affects malignant mesothelioma cell growth in vitro and in vivo(Oncogenesis, (2026), 15, (29), 10.1038/s41389-026-00639-9). / Manente, A. G.; Valenti, D.; Pinton, G. et al.
In: Oncogenesis, Vol. 15, No. 1, 29, 12.2026.

Research output: Contribution to journal › Comment/debate

TY - JOUR

T1 - Editorial Expression of Concern

T2 - Estrogen receptor β activation impairs mitochondrial oxidative metabolism and affects malignant mesothelioma cell growth in vitro and in vivo(Oncogenesis, (2026), 15, (29), 10.1038/s41389-026-00639-9)

AU - Manente, A. G.

AU - Valenti, D.

AU - Pinton, G.

AU - Jithesh, P. V.

AU - Daga, A.

AU - Rossi, L.

AU - Gray, S. G.

AU - O’Byrne, K. J.

AU - Fennell, D. A.

AU - Vacca, R. A.

AU - Nilsson, S.

AU - Mutti, L.

AU - Moro, L.

PY - 2026/12

Y1 - 2026/12

N2 - The Editor-in-Chief would like to alert readers that concerns were raised regarding potential splicing between lanes 2 and 3 of ERβ/High ERβ panel of Figure 1b and between lanes 3 and 4 of the ERβ/cytosol panel of Figure 3a. The authors have stated that the data are no longer available due to the age of the study. Therefore, readers are advised to interpret the data listed above with caution. L Moro, S G Gray, R A Vacca, and G Pinton agree with this Editorial Expression of Concern. A G Manente, P V Jithesh, K J O’Byrne, D A Fennell, S Nilsson, and L Mutti did not reply to correspondence from the Publisher about this Editorial Expression of Concern. The Publisher was unable to contact D Valenti, A Daga, and L Rossi.

AB - The Editor-in-Chief would like to alert readers that concerns were raised regarding potential splicing between lanes 2 and 3 of ERβ/High ERβ panel of Figure 1b and between lanes 3 and 4 of the ERβ/cytosol panel of Figure 3a. The authors have stated that the data are no longer available due to the age of the study. Therefore, readers are advised to interpret the data listed above with caution. L Moro, S G Gray, R A Vacca, and G Pinton agree with this Editorial Expression of Concern. A G Manente, P V Jithesh, K J O’Byrne, D A Fennell, S Nilsson, and L Mutti did not reply to correspondence from the Publisher about this Editorial Expression of Concern. The Publisher was unable to contact D Valenti, A Daga, and L Rossi.

UR - https://www.scopus.com/pages/publications/105042604179

U2 - 10.1038/s41389-026-00639-9

DO - 10.1038/s41389-026-00639-9

M3 - Comment/debate

AN - SCOPUS:105042604179

SN - 2157-9024

VL - 15

JO - Oncogenesis

JF - Oncogenesis

IS - 1

M1 - 29

ER -

Editorial Expression of Concern: Estrogen receptor β activation impairs mitochondrial oxidative metabolism and affects malignant mesothelioma cell growth in vitro and in vivo(Oncogenesis, (2026), 15, (29), 10.1038/s41389-026-00639-9)

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