Early events in the assembly of E-cadherin adhesions

Kabir H. Biswas; Ronen Zaidel-Bar

doi:10.1016/j.yexcr.2017.02.037

Early events in the assembly of E-cadherin adhesions

Kabir H. Biswas^*, Ronen Zaidel-Bar

^*Corresponding author for this work

National University of Singapore

Research output: Contribution to journal › Review article › peer-review

30 Citations (Scopus)

Abstract

E-cadherin is a calcium dependent cell adhesion molecule that is key to the organization of cells in the epithelial tissue. It is a multidomain, trans-membrane protein in which the extracellular domain forms the homotypic, adhesive interaction while the intracellular domain interacts with the actin cytoskeleton through the catenin family of adaptor proteins. A number of recent studies have provided novel insights into the mechanism of adhesion formation by this class of adhesion proteins. Here, we describe an updated view of the process of E-cadherin adhesion formation with an emphasis on the role of molecular mobility, clustering, and active cellular processes.

Original language	English
Pages (from-to)	14-19
Number of pages	6
Journal	Experimental Cell Research
Volume	358
Issue number	1
DOIs	https://doi.org/10.1016/j.yexcr.2017.02.037
Publication status	Published - 1 Sept 2017
Externally published	Yes

Keywords

Cadherin
Catenin
Cell-cell adhesion
Clustering
Cytoskeleton
Diffusion
Filopodia

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10.1016/j.yexcr.2017.02.037

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title = "Early events in the assembly of E-cadherin adhesions",

abstract = "E-cadherin is a calcium dependent cell adhesion molecule that is key to the organization of cells in the epithelial tissue. It is a multidomain, trans-membrane protein in which the extracellular domain forms the homotypic, adhesive interaction while the intracellular domain interacts with the actin cytoskeleton through the catenin family of adaptor proteins. A number of recent studies have provided novel insights into the mechanism of adhesion formation by this class of adhesion proteins. Here, we describe an updated view of the process of E-cadherin adhesion formation with an emphasis on the role of molecular mobility, clustering, and active cellular processes.",

keywords = "Cadherin, Catenin, Cell-cell adhesion, Clustering, Cytoskeleton, Diffusion, Filopodia",

author = "Biswas, \{Kabir H.\} and Ronen Zaidel-Bar",

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doi = "10.1016/j.yexcr.2017.02.037",

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T1 - Early events in the assembly of E-cadherin adhesions

AU - Biswas, Kabir H.

AU - Zaidel-Bar, Ronen

PY - 2017/9/1

Y1 - 2017/9/1

N2 - E-cadherin is a calcium dependent cell adhesion molecule that is key to the organization of cells in the epithelial tissue. It is a multidomain, trans-membrane protein in which the extracellular domain forms the homotypic, adhesive interaction while the intracellular domain interacts with the actin cytoskeleton through the catenin family of adaptor proteins. A number of recent studies have provided novel insights into the mechanism of adhesion formation by this class of adhesion proteins. Here, we describe an updated view of the process of E-cadherin adhesion formation with an emphasis on the role of molecular mobility, clustering, and active cellular processes.

AB - E-cadherin is a calcium dependent cell adhesion molecule that is key to the organization of cells in the epithelial tissue. It is a multidomain, trans-membrane protein in which the extracellular domain forms the homotypic, adhesive interaction while the intracellular domain interacts with the actin cytoskeleton through the catenin family of adaptor proteins. A number of recent studies have provided novel insights into the mechanism of adhesion formation by this class of adhesion proteins. Here, we describe an updated view of the process of E-cadherin adhesion formation with an emphasis on the role of molecular mobility, clustering, and active cellular processes.

KW - Cadherin

KW - Catenin

KW - Cell-cell adhesion

KW - Clustering

KW - Cytoskeleton

KW - Diffusion

KW - Filopodia

UR - https://www.scopus.com/pages/publications/85013638275

U2 - 10.1016/j.yexcr.2017.02.037

DO - 10.1016/j.yexcr.2017.02.037

M3 - Review article

C2 - 28237244

AN - SCOPUS:85013638275

SN - 0014-4827

VL - 358

SP - 14

EP - 19

JO - Experimental Cell Research

JF - Experimental Cell Research

IS - 1

ER -

Early events in the assembly of E-cadherin adhesions

Abstract

Keywords

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