TY - JOUR
T1 - DNA methylation in peripheral tissues and left-handedness
AU - BIOS Consortium
AU - Management Team
AU - Cohort collection
AU - Data Generation
AU - Data management and computational infrastructure
AU - Data Analysis Group
AU - Odintsova, Veronika V.
AU - Suderman, Matthew
AU - Hagenbeek, Fiona A.
AU - Caramaschi, Doretta
AU - Hottenga, Jouke Jan
AU - Pool, René
AU - Dolan, Conor V.
AU - Ligthart, Lannie
AU - van Beijsterveldt, Catharina E.M.
AU - Willemsen, Gonneke
AU - de Geus, Eco J.C.
AU - Beck, Jeffrey J.
AU - Ehli, Erik A.
AU - Cuellar-Partida, Gabriel
AU - Evans, David M.
AU - Medland, Sarah E.
AU - Relton, Caroline L.
AU - Boomsma, Dorret I.
AU - van Dongen, Jenny
AU - Heijmans, Bastiaan T.
AU - ’t Hoen, Peter A.C.
AU - van Meurs, Joyce
AU - Isaacs, Aaron
AU - Jansen, Rick
AU - Franke, Lude
AU - Boomsma, Dorret I.
AU - Pool, René
AU - van Greevenbroek, Marleen M.J.
AU - Stehouwer, Coen D.A.
AU - van der Kallen, Carla J.H.
AU - Schalkwijk, Casper G.
AU - Wijmenga, Cisca
AU - Zhernakova, Sasha
AU - Tigchelaar, Ettje F.
AU - Slagboom, P. Eline
AU - Beekman, Marian
AU - Deelen, Joris
AU - van Heemst, Diana
AU - Veldink, Jan H.
AU - Van den Berg, Leonard H.
AU - van Duijn, Cornelia M.
AU - Hofman, Bert A.
AU - Isaacs, Aaron
AU - Uitterlinden, André G.
AU - van Meurs, Joyce
AU - Jhamai, P. Mila
AU - Verbiest, Michael
AU - Suchiman, H. Eka D.
AU - Verkerk, Marijn
AU - van der Breggen, Ruud
N1 - Publisher Copyright:
© The Author(s) 2022.
PY - 2022/12
Y1 - 2022/12
N2 - Handedness has low heritability and epigenetic mechanisms have been proposed as an etiological mechanism. To examine this hypothesis, we performed an epigenome-wide association study of left-handedness. In a meta-analysis of 3914 adults of whole-blood DNA methylation, we observed that CpG sites located in proximity of handedness-associated genetic variants were more strongly associated with left-handedness than other CpG sites (P = 0.04), but did not identify any differentially methylated positions. In longitudinal analyses of DNA methylation in peripheral blood and buccal cells from children (N = 1737), we observed moderately stable associations across age (correlation range [0.355–0.578]), but inconsistent across tissues (correlation range [− 0.384 to 0.318]). We conclude that DNA methylation in peripheral tissues captures little of the variance in handedness. Future investigations should consider other more targeted sources of tissue, such as the brain.
AB - Handedness has low heritability and epigenetic mechanisms have been proposed as an etiological mechanism. To examine this hypothesis, we performed an epigenome-wide association study of left-handedness. In a meta-analysis of 3914 adults of whole-blood DNA methylation, we observed that CpG sites located in proximity of handedness-associated genetic variants were more strongly associated with left-handedness than other CpG sites (P = 0.04), but did not identify any differentially methylated positions. In longitudinal analyses of DNA methylation in peripheral blood and buccal cells from children (N = 1737), we observed moderately stable associations across age (correlation range [0.355–0.578]), but inconsistent across tissues (correlation range [− 0.384 to 0.318]). We conclude that DNA methylation in peripheral tissues captures little of the variance in handedness. Future investigations should consider other more targeted sources of tissue, such as the brain.
UR - https://www.scopus.com/pages/publications/85127478377
U2 - 10.1038/s41598-022-08998-0
DO - 10.1038/s41598-022-08998-0
M3 - Article
C2 - 35379837
AN - SCOPUS:85127478377
SN - 2045-2322
VL - 12
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 5606
ER -