TY - JOUR
T1 - Discovery of 42 genome-wide significant loci associated with dyslexia
AU - 23andMe Research Team
AU - Quantitative Trait Working Group of the GenLang Consortium
AU - Doust, Catherine
AU - Fontanillas, Pierre
AU - Eising, Else
AU - Gordon, Scott D.
AU - Wang, Zhengjun
AU - Alagöz, Gökberk
AU - Molz, Barbara
AU - Aslibekyan, Stella
AU - Auton, Adam
AU - Babalola, Elizabeth
AU - Bell, Robert K.
AU - Bielenberg, Jessica
AU - Bryc, Katarzyna
AU - Bullis, Emily
AU - Coker, Daniella
AU - Partida, Gabriel Cuellar
AU - Dhamija, Devika
AU - Das, Sayantan
AU - Elson, Sarah L.
AU - Filshtein, Teresa
AU - Fletez-Brant, Kipper
AU - Freyman, Will
AU - Gandhi, Pooja M.
AU - Heilbron, Karl
AU - Hicks, Barry
AU - Hinds, David A.
AU - Jewett, Ethan M.
AU - Jiang, Yunxuan
AU - Kukar, Katelyn
AU - Lin, Keng Han
AU - Lowe, Maya
AU - McCreight, Jey
AU - McIntyre, Matthew H.
AU - Micheletti, Steven J.
AU - Moreno, Meghan E.
AU - Mountain, Joanna L.
AU - Nandakumar, Priyanka
AU - Noblin, Elizabeth S.
AU - O’Connell, Jared
AU - Petrakovitz, Aaron A.
AU - Poznik, G. David
AU - Schumacher, Morgan
AU - Shastri, Anjali J.
AU - Shelton, Janie F.
AU - Shi, Jingchunzi
AU - Shringarpure, Suyash
AU - Tran, Vinh
AU - Tung, Joyce Y.
AU - Wang, Xin
AU - Hottenga, Jouke Jan
N1 - Publisher Copyright:
© 2022, The Author(s).
PY - 2022/11
Y1 - 2022/11
N2 - Reading and writing are crucial life skills but roughly one in ten children are affected by dyslexia, which can persist into adulthood. Family studies of dyslexia suggest heritability up to 70%, yet few convincing genetic markers have been found. Here we performed a genome-wide association study of 51,800 adults self-reporting a dyslexia diagnosis and 1,087,070 controls and identified 42 independent genome-wide significant loci: 15 in genes linked to cognitive ability/educational attainment, and 27 new and potentially more specific to dyslexia. We validated 23 loci (13 new) in independent cohorts of Chinese and European ancestry. Genetic etiology of dyslexia was similar between sexes, and genetic covariance with many traits was found, including ambidexterity, but not neuroanatomical measures of language-related circuitry. Dyslexia polygenic scores explained up to 6% of variance in reading traits, and might in future contribute to earlier identification and remediation of dyslexia.
AB - Reading and writing are crucial life skills but roughly one in ten children are affected by dyslexia, which can persist into adulthood. Family studies of dyslexia suggest heritability up to 70%, yet few convincing genetic markers have been found. Here we performed a genome-wide association study of 51,800 adults self-reporting a dyslexia diagnosis and 1,087,070 controls and identified 42 independent genome-wide significant loci: 15 in genes linked to cognitive ability/educational attainment, and 27 new and potentially more specific to dyslexia. We validated 23 loci (13 new) in independent cohorts of Chinese and European ancestry. Genetic etiology of dyslexia was similar between sexes, and genetic covariance with many traits was found, including ambidexterity, but not neuroanatomical measures of language-related circuitry. Dyslexia polygenic scores explained up to 6% of variance in reading traits, and might in future contribute to earlier identification and remediation of dyslexia.
UR - https://www.scopus.com/pages/publications/85142937214
U2 - 10.1038/s41588-022-01192-y
DO - 10.1038/s41588-022-01192-y
M3 - Article
AN - SCOPUS:85142937214
SN - 1061-4036
VL - 54
SP - 1621
EP - 1629
JO - Nature Genetics
JF - Nature Genetics
IS - 11
ER -