Design, synthesis and SAR of new-di-substituted pyridopyrimidines as ATP-competitive dual PI3Kα/mTOR inhibitors

  • Aisha A.K. Al-Ashmawy
  • , Fatma A. Ragab
  • , Khaled M. Elokely
  • , Manal M. Anwar
  • , Oscar Perez-Leal
  • , Mario C. Rico
  • , John Gordon
  • , Eugeney Bichenkov
  • , George Mateo
  • , Emad M.M. Kassem
  • , Gehan H. Hegazy
  • , Magid Abou-Gharbia
  • , Wayne Childers*
  • *Corresponding author for this work

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Pharmacology, Toxicology and Pharmaceutical Science