Composite template membranes as synthetic receptor systems 1. Preparation, specificity and template effect

Molecularly impregnated membranes for selective recognizing of adenosine 3',5'-cyclic monophosphate (cAMP) were obtained and their separation properties were studied. Composite polyvinylidenfluoride microfiltration membranes covered with a thin layer of polymer impregnated with cAMP were prepared using photoinitiated copolymerization of dimethylaminoethylmethacrylate as a functional monomer and trimethylolpropane thrimethacrylate as a cross-linker in the presence of cAMP as a template. It was concluded that the ability of MIP membranes to selective binding of cAMP is a result of both specific shape and dimension of the recognizing site as well as specific interactions between functional groups responsible for selective template binding inside the receptor site.