Comparative roles of the cell wall and cell membrane in limiting uptake of xenobiotic molecules by Saccharomyces cerevisiae

Mustapha Aouida; Omar Tounekti; Omrane Belhadj; Lluis M. Mir

doi:10.1128/AAC.47.6.2012-2014.2003

Comparative roles of the cell wall and cell membrane in limiting uptake of xenobiotic molecules by Saccharomyces cerevisiae

Mustapha Aouida
, Omar Tounekti
, Omrane Belhadj
, Lluis M. Mir^*

^*Corresponding author for this work

Institut Gustave Roussy
Université de Tunis El Manar
Sir Mortimer B. Davis-Jewish General Hospital

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Using reversible electropermeabilization of cells and spheroplasts, we show that the cell wall and plasma membrane partly account for bleomycin resistance by acting as two independent barriers. We also report on the presence of a membrane protein that may be responsible for bleomycin internalization and toxicity in Saccharomyces cerevisiae.

Original language	English
Pages (from-to)	2012-2014
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	47
Issue number	6
DOIs	https://doi.org/10.1128/AAC.47.6.2012-2014.2003
Publication status	Published - 1 Jun 2003
Externally published	Yes

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10.1128/AAC.47.6.2012-2014.2003

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title = "Comparative roles of the cell wall and cell membrane in limiting uptake of xenobiotic molecules by Saccharomyces cerevisiae",

abstract = "Using reversible electropermeabilization of cells and spheroplasts, we show that the cell wall and plasma membrane partly account for bleomycin resistance by acting as two independent barriers. We also report on the presence of a membrane protein that may be responsible for bleomycin internalization and toxicity in Saccharomyces cerevisiae.",

author = "Mustapha Aouida and Omar Tounekti and Omrane Belhadj and Mir, \{Lluis M.\}",

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T1 - Comparative roles of the cell wall and cell membrane in limiting uptake of xenobiotic molecules by Saccharomyces cerevisiae

AU - Aouida, Mustapha

AU - Tounekti, Omar

AU - Belhadj, Omrane

AU - Mir, Lluis M.

PY - 2003/6/1

Y1 - 2003/6/1

N2 - Using reversible electropermeabilization of cells and spheroplasts, we show that the cell wall and plasma membrane partly account for bleomycin resistance by acting as two independent barriers. We also report on the presence of a membrane protein that may be responsible for bleomycin internalization and toxicity in Saccharomyces cerevisiae.

AB - Using reversible electropermeabilization of cells and spheroplasts, we show that the cell wall and plasma membrane partly account for bleomycin resistance by acting as two independent barriers. We also report on the presence of a membrane protein that may be responsible for bleomycin internalization and toxicity in Saccharomyces cerevisiae.

UR - https://www.scopus.com/pages/publications/0038778643

U2 - 10.1128/AAC.47.6.2012-2014.2003

DO - 10.1128/AAC.47.6.2012-2014.2003

M3 - Article

C2 - 12760888

AN - SCOPUS:0038778643

SN - 0066-4804

VL - 47

SP - 2012

EP - 2014

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 6

ER -

Comparative roles of the cell wall and cell membrane in limiting uptake of xenobiotic molecules by Saccharomyces cerevisiae

Abstract

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